The Swamp
RNAi Lamarckian Prions HGT transgenerational inheritance
maybe scseyhype multidimensionality smoothness
Soma germline post genomic layers of inheritance
cancer senescence telomeres as noncoding transcriptome spliceosome thtfhffifg.it I souions
translatomic proteomic foldomics
Genomic ER Proteomic e Rs
i N
Potties Hosea.es Hsp chaperone enzymes
Dantin's Memetic Theory
Schrodinger's what is Life defining gene is an aperiodic cystal that contains info in its differential patterning can be argued that it applies generally beyond miffities the middle step protein crystal structure also as modular aperiodicity
Before I begin mouthing off about my potentially errant S ill conceived concerns interpretations about these notions withstanding in thetheoretics of Biology I'd like to remind you that as Sophocles first wrote Don't shoo.IE yengerhi y pothichemiustamessengernthistopies
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his Science progresses funeralbyfuneral quote Pivotal discoveries gothrough 3 distinct phases
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1 That's absurd Crazy clearly wrong Goaway t E f ftp i oubyYreutaienY
2 That'strivial You're notsaying anything special.nl e ff I wthat.dfIandwennew itbefore you did
I think that the topics I will discuss here currently fall in the phase
No part of this is intended to come off as me trying to represent some new ground breaking conception infactmostof it I willcitetoratheroldpapers I am merelytrying to shedlightonsomeof the rather longstanding Elephants in the room that will be definitely not boasted butperhaps quietly acknowledged bythe Biologists reading
These are merely my observations of a stenching silence so far as I can smell from my time currently studying this fascinating world from within the institutions
First Perhaps While un novel it certainly bothers confuses me why a larger fuss is not made of it the basics
icentraldogmatmolecularfiology
Teculalogyfrbiooat multilayered.cm rgentstrataoffunctions.You'vegottheexplicit genetic contents Genomics everycell in your body hasthesamegenomics andyetyoureye muscle cellought to be reading and expressing different sections of thatDNAfortheir respectively intended
Eachcell marks each ofthesesections of gene with an on methyltag clts
Forthose genes that are on iisii.ie iiiiiiiiiii'ii.fiii i iihiiii iiii.itiiiiiiii
inst transcribed into messengerRNA mRNAthin transcribing atemporary COPY of a rare fffbff _getheoriginalrecipeDNAtheli.brany to bring home as i oaioootiiiiii.fiiiitiii i iiiiii
Second themRNA is readby a ribosome which
Third The polypeptide chainthenfoldsitselfinto translates the code ofthe mRNA into a chain a veryparticularshape This is what we call ᵈ
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ff ftp.fffffff
One mayconsider mRNA to merely be a cisacting local temporary acutely acting
The idea here is that it was thought he Ltoftintegration
Such would Imply
it became clear that no suchdogma prevailed 100 are f fÉÉfÉÉfÉÉÉ pa t thediscovery ofReverseTranscriptaseinViruses anenzyme converting RNA DNA This potential of temporaryviral transcripts to embed themselvesintotheSomaSGermline Hanorganismpavedthe wayothediscoveryotEndogenous RetroViruses EVs tobediscoveredOneoughtto rememberthat a Succesful Hijacker is notone whoinflictsthedeadliesteffectsbutrathertheonewhomisable to mostsilentlyembedits packages ERVs are exactly these SuccesfulViruseswhohavealready won in embedding theircode into thehostgenome meaningthattheorganism will endogenously reproduce thoseviruses wheneverthatgene is expressed Thisthenalsopavedthewayfor a morecomprehensiveviewof the Originof life regards to thediscovery ofHorizontalGeneIranste
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uptheImysteyEsAltmansTobelprizeFdiscovringCatalytic
erspice
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nanobot function tothem besides the 4lettercodetheycontain FÉ f i1 y a Idan the fff likeproteinEnzymes Crick Orgel came upwith the RNA world hypothesis suggesting thatthe firstearly on Isoflie were RNA based RNP
main protein fiff
ffi
Activity in RNA ribozymes I wrote previouslythatproteinsare theonesthatfoldu andformcoolfunctional nanomachines but I kindof lied because it was discoveredthatRNAcanalsotold f ig
f formsof life
There are manythings leftout of thisdiagram I drewearlier Namely somethingvery
I Ifhffffidfh I ÉÉffÉÉ Ékhiffh f iÉÉÉÉ ffff.hnfffffafhhf.y
Thismay sound crazily counterintuitive butmost of thegenomedoesn't actuallycodeforanyprotein 250 are just repetitivesequences like CAGCAGCAG or GCGCGC etcwhichwillcomeimportantlaterAfter t.it ii iiiiitiii n madhi
feed Him t.in iiieii.es
What happens to the spliced out introns is an entire world of interesting functions manybecomethe aforementioned catalyticRNA machines
Onesuch prominent motif theme of these RNA shapes is the the road as an indicator that the driver oughtto hitthe brakes and in ii t.n.name the enzymegets stuckon terminatingthe process In general one may considertheHairpin as a symbol of inhibition interference
I discoveredbyC Mello and A Fire in 1998 deemedbullshitformanyyears
Introducing RNAiinterference astoldto mebyonepostdoc before subsequentlywinningtheNobel8yrslater neitherofwhich are actually proteincoding I fish
Titania initiated na to bind disable silence mRNA transcripts I MicroRNA In P ftp.tm.gffi ffin9sma These small shortsequences ofRNA are intended togoaroundlookingfortheirpartnersequences recall that mRNA is a singlestranded molecule meaningthatif it is boundby a complimentarystrandofRNA itbecome
Éy f fffffÉfÉ f ff giff tttÉÑ t f
intention ItsthoughtthattheseRNAi molecules serve amongotherfunctions y y as virus defense mechanisms where theseRNAi molecules act as 24 7 Standing guards in the cytosol waiting for someViralRNA f to come into the cell immediatelyready to bind to and disable the viralRNA from beingtranslatedinto a protein
Againdon'tshootthemessenger f ᵗ fz
Forthatreason ofdiii yyfg
This is largely wherethey think siRNA miRNA differ siRNA thought to primarily bethis anti virus mechanism of MolMemory likekeepingremnants of oncedefeated enemies onyourlawn to preventfuture attacks WhilemiRNAserves likely asay at endogenousgene transcription regulator much like Epigenetics but at a post Genomic post transcriptomic layer
