ECCO 2012 Congress - Barcelona

Page 1

Barcelona

Spain

February 16th to 18th, 2012

Part 1

European Crohn´s and Colitis Organization ECCO 2012 Achieving Therapeutic Success in Pediatric and Adult Patients

Redefining Expectations of Infliximab Therapy in Ulcerative Colitis.

Importance of intestinal mucosal healing in ulcerative colitis Dr. Jean-Frédéric Colombel. Professor of Hepato-Gastroenterology, Lille University, France. President of ECCO (European Crohn´s and Colitis Organization) The definition of intestinal mucosal healing in patients diagnosed with ulcerative colitis (UC) varies in the different clinical studies conducted up to present times. Several parameters are usually used, such as the Rachmilewitz Index (inferior to 2 and/ or inferior to 4), modified Sutherland Index (inferior to 1), the Baron Scale (inferior to 1), and the Mayo endoscopic subscore (value between 0 and 1). Mayo endoscopic subscore introduces four lesion grades characterizing ulcerative colitis1. Grade 0 defines the normal intestinal mucosa or inactive disease; grade

1 determines a mild disease (erythema, reduced vascular patter, and mild friability); grade 2 defines a moderate disease (marked erythema, absent vascular pattern, erosions, friabilty); and grade 3 consists of a severe disease with spontaneous bleeding and ulcers1. According to ECCO (European Crohn and Colitis Organization) clinical practice guidelines, UC remission is defined as a complete resolution of symptoms and endoscopic healing of the intestinal mucosa2. Two clinical studies have been conducted to assess the efficacy of infliximab as induction and maintenance treatment in adult patients with ulcerative colitis (ACT I and ACT II – Active Ulcerative Colitis Trial)3. Both studies included 364 patients with a moderately to severely active ulcerative colitis, who,


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