Research & reviews journal of oncology and hematology (vol3, issue2) by STM Journals Publication

eISSN: 2319-3387

(RRJoOH)

Research & Reviews

Journal of Oncology & Hematology

May - August 2014

(RRJHS)

端 Changing Trends in Advanced Epithelial Ovarian Cancer - A Review 端 Physiotherapy Service and Its Impact on the Quality of Life in Breast Cancer Patients 端 Carcinoma Penis in Previously Circumscribed Male: A Case Report 端 Unusual Distant Metastasis in Buccal Squamous Cell Carcinoma: A Case Report

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Editorial Board

Prof. Satheesan Balasubramanian Director, Professor and Head of Department of Surgical Oncology Malabar Cancer Centre, Thlassery, Kannur, India.

Prof Thangarajan Rajkumar Professor and Head, Dept. of Molecular Oncology,Cancer Institute (WIA), Adyar, Madras, India.

Professor Keechilat Pavithran Department of Medicaloncology and Hematology, Amrita Institute of Medical Sciences P.O. AIMS Ponekkara Cochin, India.

Chinmay Kumar Panda Dept. of Oncogene Regulation Chittaranjan National Cancer Institute, Kolkata, India.

Dr. Rakesh Jalali Professor of Radiation Oncology Convener, NeuroOncology Group, Tata Memorial Hospital Parel, Mumbai India.

Dr Dillip Kumar Parida Head, Department of Oncology, Maw Diang Diang, Shillong, Meghalaya, India.

Dr. Pritha Ray Assistant Professor and Principle Investigator Tata Memorial Centre, India.

Dr. Lalit Kumar Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital, AIIMS Department of Medical Oncology, India.

Fayaz Ahmad Malik Scientist Department of Cancer Pharmacology Indian Institute of Integrative Medicine, India.

Ms Krishna P. Gupta Carcinogenesis Labratory,Indian Institute of Toxicology Research,M.G.Marg, Lucknow, India.

Dr Arun Chaturvedi Senior Consultant & Head of Surgical Oncology Sahara India Medical Institute Ltd. Lucknow, India.

Dr. D.K. Vijaykumar Prof. & Head, Dept. of Surgical Oncology Amrita Institute of Medical Sciences & Research CentrePonekkara P.O., Cochin Kerala, India.

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STM JOURNALS

I take the privilege to present the hard copy compilation for the [Volume 3 Issue (2)] of Research & Reviews: Journal of Oncology and Hematology. The intension of RRJoOH is to create an atmosphere that stimulates creativeness, research and growth in the area of Oncology and Hematology. The development and growth of the mankind is the consequence of brilliant Research done by eminent Scientists and Engineers in every field. RRJoOH provides an outlet for Research findings and reviews in areas of Oncology and Hematology found to be relevant for National and International recent developments & research initiative. The aim and scope of the Journal is to provide an academic medium and an important reference for the advancement and dissemination of Research results that support high level learning, teaching and research in the domain of Oncology and Hematology. Finally, I express my sincere gratitude and thanks to our Editorial/ Reviewer board and Authors for their continued support and invaluable contributions and suggestions in the form of authoring writeups/ reviewing and providing constructive comments for the advancement of the journals. With regards to their due continuous support and co-operation, we have been able to publish quality Research/Reviews findings for our customers base. I hope you will enjoy reading this issue and we welcome your feedback on any aspect of the Journal.

Dr. Archana Mehrotra Director STM Journals

Research & Reviews: Journal of Oncology and Hematology

Contents

1. Changing Trends in Advanced Epithelial Ovarian Cancer - A Review Vijaykumar D.K, Anupama Rajanbabu

2. Physiotherapy Service and Its Impact on the Quality of Life in Breast Cancer Patients Bhatri Pratim Dowarah

3. Carcinoma Penis in Previously Circumscribed Male: A Case Report Santosh Koppal

4. Unusual Distant Metastasis in Buccal Squamous Cell Carcinoma: A Case Report Venkatesan Ranganathan, Tejal Gorasia, Dheraj Khadakban, Kiran Gulabrao Bagul

Research & Reviews: Journal of Oncology and Hematology ISSN: 2319-3387 (online) Volume 3, Issue 2 www.stmjournals.com

Changing Trends in Advanced Epithelial Ovarian Cancer - A Review Vijaykumar D.K*, Anupama Rajanbabu Department of Gynecologic Oncology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwavidyapeetham, Cochin-682041, Kerala, India Abstract Despite the advances in surgery and chemotherapy, the outcome of patients affected with advanced epithelial ovarian cancer continues to be poor. Now researchers are looking at ovarian cancer through newer perspectives so as to find better treatment modalities that can improve overall survival (OS). In this chapter, we have briefly reviewed the newer areas of research in epithelial ovarian cancer. We look at how better understanding of the molecular biology, changes in mode of chemotherapy administration and newer targeted agents have improved the outlook for the future.

Keywords: Epithelial ovarian cancer, Cancer stem cell, Optimal debulking, Chemotherapy in ovarian cancer

Research & Reviews: Journal of Oncology and Hematology ISSN: 2319-3387 (online) Volume 3, Issue 2 www.stmjournals.com

Physiotherapy Service and Its Impact on the Quality of Life in Breast Cancer Patients Bhatri Pratim Dowarah* Dr. B. Barooah Cancer Institute, Guwahati, Assam, India Abstract The study is based on the physiotherapy interventions in the breast cancer patients in North-east India based on the samples, population studied and treatment plans in Dr. B. Barooah Cancer Institute, Guwahati, Assam. The main objective of the study was to make the people of India especially north-east India to be aware regarding the breast cancer and promotion of importance and rules of physiotherapy treatment in the breast cancer rehabilitation process. The results suggest that the pressing need arises for the existence of a differentiated care system with the purpose to cater for the particular needs of the patients and their families. It is desirable that the physiotherapist working in oncology has a broad knowledge of other clinical areas, such as neurology, the musculoskeletal and cardiopulmonary systems and in rehabilitation and kinesiotherapy in general, as well as in services along the entire spectrum of patient care. In conclusion, the authorâ&#x20AC;&#x2122;s metaanalysis indicated that the addition of MLD to compression and exercise therapy for the treatment of lymphedema after axillary lymph-node dissection for breast cancer is unlikely to produce a significant reduction in the volume of the affected arm.

Keywords: Breast cancer, North-east India, role of physiotherapist, MLD

Research & Reviews: Journal of Oncology and Hematology ISSN: 2319-3387 (online) Volume 3, Issue 2 www.stmjournals.com

Carcinoma Penis in Previously Circumscribed Male: A Case Report Santosh Koppal* Consultant Laparoscopic and General Surgeon, Department of General and Laparoscopic Surgery, Arogya Hospitals Ltd., Ongole, Andhra Pradesh, India Abstract Mr. PN 75yrs/m noticed a small ulcer over glans penis 4 months back, gradually increased in size eroding glans and became fungating mass. History of scanty bloody & pus discharge. History of burning sensation while passing urine frequently. No premorbid illnesses. No abdominal complaints. No swellings in the both groin regions. Previously 8months back patient was circumscribed in a local hospital but details not available. Examination revealed a foul smelling fungating ulcer of size 4x3cms present over glans with everted margins eroding glans penis. Induration present upto 0.5cm from growth and bleeds on touch. Thick pus discharge resent from growth. External urethral meatus could not visualized. Non-significant inguinal nodes present. No mass per abdomen.Patient was admitted and investigations revealed normal haemogram with urinary infection. USG abdomen & pelvis showed small bilateral inguinal nodes, no pre/para aortic LN, CT abdomen & pelvis - no retroperineal nodes, small reactive inguinal nodes, Biopsy from growth showed well differentiated SCC. Patient was treated for UTI and underwent Partial Penectomy under spinal anaesthesia.

Keywords: Circumscission, Glans Penis, Ulcerative growth, Inguinal lymphnodes, Carcinoma in situ

Research & Reviews: Journal of Oncology and Hematology ISSN: 2319-3387 (online) Volume 3, Issue 2 www.stmjournals.com

Unusual Distant Metastasis in Buccal Squamous Cell Carcinoma: A Case Report Venkatesan Ranganathan*, Tejal Gorasia, Dheraj Khadakban, Kiran Gulabrao Bagul Dept. of Surgical Oncology, Amrita Institute of Medical Sciences & Research Centre, Cochin-682041, Kerala, India

Abstract Head and neck squamous cell carcinomas (SCC) are known to have high loco regional recurrence with distant mets being rare. However, distant metastasis are showing an increasing trend due to the improved locoregional control rates achieved with surgery and radiotherapy. The usual sites of distant failure are lung, liver, bone, adrenal, heart and kidney. Here is presented a case of buccal SCC presenting with unusual distant soft tissue mets after several years of diagnosis.

Keywords: Squamous cell carcinoma, distant metastasis, diagnosis