Parade 5 8 16

SUN DAY, M AY

THE

8, 2 01 6 | PA RADE .COM

MOUSE THAT

ONE MOM’S FIGHT AGAINST

CANCER —AND THE MIRACLE CURE THAT SAVED HER LORI ALF, multiple myeloma survivor © PARADE Publications 2016. All rights reserved.

T ’S

Is Patti LuPone headed back to Broadway? She is such a talented singer and I would like to catch her on my next trip to New York.

—Gerald L., Milwaukee, Wis.

WALTER SCOTT ASKS...

CYNDI LAUPER

The “Girls Just Want to Have Fun” singer, 62, takes a musical Detour with the release of her new country classics album. No surprise, this ’80s lady puts her unique spin on country tunes from the ’40s, ’50s and ’60s.

Are you a recent country convert? No, I always listened to country. There were some country artists that were “more” than country. They were big icons in the rock ’n’ roll community, like Patsy Cline.

She was a rockabilly gal.

How did you decide which songs to include on Detour? There are a lot of great ones, because country music’s very soulful. “Misty Blue” is a perfect example of a country song crossing over to soul, because Dorothy Moore had a hit with it on the soul charts 10 years after Wilma Burgess [did on the country charts].

Are you nervous about starting your tour May 9 at Nashville’s Ryman Auditorium, where every great country artist has performed? It’s a little nerve-racking. I want to be great, but sometimes you’ve got to just let go and be happy to be there.

What were Lauper’s musical influences?

Go to Parade.com/cyndi to find out.

Detour is an album of cover songs.

What cover versions of your songs have you enjoyed? I heard Patti LaBelle sing “Time After Time.”

That had to be one of the most extraordinary experiences. I also heard a really fun version of “She Bop” that I thought was awesome.

A: The Tony Award–winning actress for Gypsy and Evita, who was last seen in the off-Broadway production Shows for Days in 2015, has been touring with a series of classic show-tunes concerts called Don’t Monkey With Broadway. But if you can’t swing a ticket, check out Showtime’s Penny Dreadful on Sunday nights. She joined the cast this season in the role of Dr. Seward, a therapist who treats Vanessa (Eva Green) with an unconventional new approach.

BACON

Kevin Bacon, 57, stars in a new horror film, The Darkness, about a family that brings back a supernatural souvenir from their vacation at the Grand Canyon. It opens, appropriately enough, on Friday, May 13. But first, here are five facts about the Philadelphia-born actor/musician.

1. He and brother Michael perform as the musical duo the Bacon Brothers.

2. His father, a famous Philadelphia city planner, was featured on the cover of Time magazine in 1964.

So how does the girl have fun these days? I really have been working quite a bit. I’m a mom, a wife, a daughter and a sister, so it’s hard to juggle everything all at once, but I’m trying. Not a lot of fun!

3. In 2010, J&D Foods commissioned a larger-than-life-size bust of Bacon made out of bacon.

Auctioned off for charity, it was named Bacon Kevin Bacon.

Email your questions for Walter Scott to personality@parade.com

4. The game Six Degrees of Kevin Bacon came about because the actor has appeared in so many films, with so many co-stars, he can be linked to almost any other actor in six steps or less.

With 2014’s The Grand Budapest Hotel and now A Bigger Splash, Ralph Fiennes seems to have discovered his funny side. How did that happen?

—Thomas H., Beaufort, S.C. A: Fiennes is best known, indeed, for his darker characters in Schindler’s List, The English Patient and the Harry Potter franchise, but he’s always up for a good comedy role when one comes around. In A Bigger Splash (in theaters May 4), he plays Harry, a record producer who interrupts the holiday of an old flame (Tilda Swinton). “I don’t think I had ever been asked to play a guy who gets naked and dances and sings bad karaoke before,” says Fiennes, 53.

Mmmmm...

Fiennes and Tilda Swinton co-star in the new movie A Bigger Splash.

5. Bacon and wife Kyra Sedgwick discovered they are ninth cousins when they appeared on PBS’ ancestry search series Finding Your Roots.

2 | MAY 8, 2016

© PARADE Publications 2016. All rights reserved.

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L I K E U S AT FA C E B O O K . C O M / PA R A D E M A G

A HALLMARK MOMENT Americans have been officially celebrating Mom since 1908, but it wasn’t until 1920, when Hallmark began selling Mother’s Day cards, that the holiday became a card-carrying occasion. Today there are also cards for stepmoms, same-sex moms and “pet moms.” Visit Parade.com/momcards for a gallery of Hallmark cards over the years.

Relive your favorite mix-tape days with the I Love the ’90s Tour. The show will play 35 danceable dates with a roster of recognizable R&B, rap and hip-hop acts, including Salt-N-Pepa, Vanilla Ice, Coolio, Color Me Badd and Tone Loc, to name a nostalgic few.

Visit ilovethe90stour.com for dates and ticket information.

FLASHBACK

1978 50 YEARS OF THE FINAL FRONTIER It’s the golden anniversary of Star Trek, and fans are celebrating all year long with Trek Talks, conventions and more. (Parade celebrated the first Star Trek film with a trip to the movie set in 1978.) Visit Parade.com/startrek or startrek.com for more info.

4 | MAY 8, 2016

© PARADE Publications 2016. All rights reserved.

SPICOLI BY UNIVERSAL PICTURES/NEWSCOM; VANILLA ICE BY THE LIFE PICTURE COLLECTION/GETTY IMAGES; SALT-N-PEPA BY JANETTE BECKMAN/GETTY IMAGES

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t’s hard to forget Sean Penn (Spicoli) sporting Vans checkerboard slip-ons in the 1982 classic Fast Times at Ridgemont High, but the shoemaker actually launched 16 years earlier in a corner shop in Anaheim, Calif. This year Vans is celebrating 50 years with a special collection (including the checkerboards) and a book about the iconic canvas shoe. Vans: Off the Wall, 50th Anniversary Edition (Abrams) brings to life Vans culture and couture. $30, Barnes & Noble stores and online; “Checkered Past” shoe line, prices vary, at select retailers

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Š PARADE Publications 2016. All rights reserved.

TH E

MOUSE THAT

With only weeks to live, Lori Alf volunteered for a therapy that hadn’t even been tested on mice.

Her cancer vanished—and medical science took a leap closer to a cure.

BY FRANK LALLI COVER AND OPENING PHOTOGRAPHY BY ALISSA DRAGUN

C

arl H. June, M.D., who spends his days in a sterile research laboratory, had never met the woman who crossed the room and hugged him at a conference in New York City last fall. But she had a good reason.

Just one year earlier June had saved her from a blood cancer that might have killed her within weeks.

Lori Alf, now 50, was the first volunteer for a clinical trial using immunotherapy—which boosts the body’s natural defenses—to fight a blood cancer called multiple myeloma. The highly experimental trial was run by June at the University of Pennsylvania. To him, Alf had been only a code ending in 01, for the first anonymous patient.

But with her hug, Alf personified the millions of cancer patients June

and his colleagues hope to save by transforming a patient’s own immune system into a cancer killer.

During his presentation later that day at the Multiple Myeloma Research Foundation’s Leadership Circle Summit, June choked up as he showed Alf ’s before and after slides. In the former, round liquid myeloma tumors clog 95 percent of her bone marrow, crowding out all but a whisper of healthy cells— barely enough to survive. The second slide is completely clear.

Alf ’s cancerous blood tumors had vanished within a month or two after her treatment.

How? Researchers withdrew some of her immune system’s white blood cells, transformed them in the lab into hunters retrained to track down and kill her cancer

6 | MAY 8, 2016

© PARADE Publications 2016. All rights reserved.

cells, then let them loose in her body.

And it worked: Alf is cancer-free.

That’s nothing short of a medical miracle.

bronchitis. Her family doctor delivered the bad news: Alf had multiple myeloma, a treatable but incurable blood cancer that affects fewer than 90,000 Americans—and rarely someone so young. She was 43.

“I walked out to my car,” she says, “slumped down onto the hood and stayed there paralyzed, crying.”

But within a week, she and her husband, Chris, took control of what became a

(Above) Alf with husband Chris and children (from left) Christer, Chapin and Caterina; (right) Alf with her clinical trial doctors, Edward Stadtmauer (left) and Alfred Garfall

Findings by June and his researchers—as well as new studies—suggest that immunotherapy could fight more than two dozen types of cancer. Before too long, for example, blood cancer patients could walk into outpatient clinics and get one-time, 10-minute intravenous drips of their own commercially reprogrammed immune cells and become cancer-free within weeks.

As for Alf: “I was supposed to die.

But here I am,” she says. “I feel as if I was placed into one of the lifeboats from the Titanic—and I can’t help looking back and wishing that everyone on that ship could join me.”

A Mean Cancer

Before Alf got very lucky in the clinical trial, she was profoundly unlucky.

Back in 2009, the smart, speed-talking mother of three, who runs an Olympicclass ice rink in West Palm Beach, Fla., thought she had a worsening case of

seven-year ordeal to keep her particularly aggressive cancer in check. While many myeloma patients find therapies that allow them to enjoy the semblance of normal health for years, Alf lurched from one disappointing treatment to another, including a debilitating stem cell transplant using her own blood.

Few therapies helped her for more than months at a time. “I had a really mean cancer,” she says.

Her lead myeloma specialist, the renowned Kenneth C. Anderson, M.D., of Boston’s Dana-Farber Cancer Institute, agrees: “Lori had one of the worst myelomas I have ever seen.”

By 2014, Alf was down to 80 pounds, with a grim prognosis.

In desperation, she and her doctors were considering her second stem cell transplant, this time with cells from her

TRUTH ABOUT CLINICAL TRIALS THE

L

ori Alf’s remarkable recovery is the Hollywood version of what happens in a clinical trial. The reality can be far different. Here’s why: A clinical trial is not about the individual patient—its purpose is to test a new drug, treatment, procedure or medical device on human volunteers. What happens to the individual, good or bad, is incidental to the researchers’ discoveries about the entire group and the broader implications of the collective data.

And clinical trials can be risky. According to Center Watch, a research-information firm, about 1 in 30 participants in drug trials suffers a serious side effect and 1 in 10,000 dies.

Still, the benefits can be considerable, even barring a miracle cure. You’ll likely get the attention of experts who have spent their entire careers focused on your disease, and their insights about your case may be invaluable.

Beyond that, in trials put on by the National Institutes of Health (NIH), an arm of the U.S. Department of Health and Human Services, chances are you’ll get the cutting-edge medicines or therapies largely free of cost. You may even be compensated for your time and inconvenience, particularly if you are a healthy volunteer sought for early-stage research.

HOW TO FIND A TRIAL

To look for a trial for a specific illness, begin by consulting with your doctor; many disease specialists are familiar with trials in their fields. Then, like Alf, you can turn to the internet. Start with the comprehensive list of current trials at nih.gov. Check clinicaltrials.gov, centerwatch.com and emergingmed.com for trials and their locations. You also can find trials through nonprofit research foundations, or call and ask for the medical research department at large hospitals or universities.

If you find a trial that appears promising, circle back to your doctor or specialist for help applying. Be prepared to meet with the trial team in person to determine whether you’re a good fit.

Visit Parade.com/clinicaltrials for the five questions you should ask before signing up for a clinical trial.

MAY 8, 2016 | 7

© PARADE Publications 2016. All rights reserved.

sister, who is not a perfect genetic match. The doctors told her that the complications triggered if the transplanted cells attacked her body rather than helped her, known as graft-versus-host disease, could end her life.

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There was one other option.

Scouring the internet, Alf and her husband discovered something so new even her own doctors hadn’t heard about it.

University of Pennsylvania researchers were organizing clinical trials to reprogram the immune systems of seriously ill myeloma patients like her. Instead of using chemotherapy drugs to attack the cancer, immunotherapy assaults cancer cells from within with a patient’s own re-engineered immune system.

Alf had long believed immunotherapy—which avoids graft-versus-host complications by using the patient’s own cells—held the key to curing her cancer. She was determined to get into the trial funded by drug manufacturer Novartis. She told her then-16-year-old daughter Caterina, a competitive figure skater, “If they reject me, you go into that doctor’s office and cry your eyes out. Make a scene until they change their minds.”

But Alf was exactly the type of patient the researchers wanted— seriously ill with the abnormality they were targeting, yet hopefully strong enough to survive the rigors of the trial itself.

The stakes were high: The immunotherapy hadn’t even been tested on animals. University researchers were moving fast to treat the seriously ill myeloma volunteers under expedited 8 | MAY 8, 2016

© PARADE Publications 2016. All rights reserved.

“breakthrough” status from the U.S. Food and Drug Administration and did not stop to experiment, even on mice.

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Alf was “the mouse model.”

In a process similar to kidney dialysis, she was hooked up to a machine that collected a type of white blood cells called T cells. “Then the lab made my T cells very angry,” she explains.

Actually, the lab transformed the T cells with a protein called chimeric antigen receptor (CAR) into what they hoped would be an army of hunters that would recognize her enemy myeloma cells and kill them.

Twelve days later, the doctors dripped the red, garlicky-smelling CAR T cells into her veins. The next day, she felt sicker than ever.

But that was about what the doctors had hoped: In their earlier trials with leukemia patients, when the immune system’s army overwhelmed the enemy, the warfare commonly triggered high fevers, nausea, muscle pain and sometimes serious neurological symptoms.

MAY 8, 2016 | 9

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“Our goal is to cure cancer,” says Carl H. June, M.D., who hopes to apply the lessons from Alf’s trial to find treatments for other types of cancer.

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Fortunately, Alf was spared the worst of that and was well enough to be discharged a week later to a nearby hotel. Still, she continued to feel “jittery, itchy, twitchy and miserably nauseous.”

But her blood tumors decreased—then disappeared. “I’m sure we killed my mother cancer cells,” she says of the stem cells where cancer originates. More than one of her oncologists agree. Nothing else explains her remarkable recovery.

“I cry from happiness every time I see her,” says Alf ’s Florida oncologist Robert J. Green, M.D. “When she went to Pennsylvania, I didn’t think I’d see her alive again. Lori is proof that these new immunotherapies do magical things.”

Cancer-Free

Nearly two years later, Alf ’s blood is totally normal, and she’s finding joy in the smallest moments of life, “like the smell of my dog, Versace,” she says.

Husband Chris marvels at the resilience of the woman he fell in love with 27 years ago. And their three teenagers cherish a bedtime ritual they started in childhood, Caterina says: “We all go in and kiss her goodnight.”

Whenever possible, Alf shares her story at conferences and events in hopes of raising more research money for the treatment that saved her life.

The mighty mouse roars on.

The Health Care Detective™ Frank Lalli is producing a book for Simon & Schuster this fall on how to get affordable health care.

Go to Parade.com/lori for Alf’s three rules for fighting cancer.

10 | MAY 8, 2016

© PARADE Publications 2016. All rights reserved.

®

Ask Marilyn

By Marilyn vos Savant

Say you pick up a person who is ill but awake. While in your arms, the person loses consciousness and suddenly becomes "dead weight." Why is the person now so much heavier?

—John C., Louisburg, N.C.

The person is not actually heavier; he is just more difficult to heft because he's no longer using his muscles to hold himself together or to hold on to his helper to avoid being dropped. So his weight becomes loose and floppy with his head, arms and legs hanging down. Protestors who "go limp" do this on purpose to make themselves harder to carry off.

Consider lifting a 30-pound box of tightly packed books. Heavy, yes, but let's say you can manage. Now consider lifting a laundry bag with the same books. That's much, much harder.

Send questions to marilyn@ parade.com

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25% off ends 5/28/16.*Good Housekeeping Research Institute - Aug. 2014. $200 savings calculation was determined by averaging PERS market leaders’ monthly fees (not all PERS have the same features). Requires a one-time setup fee of $35 and valid credit or debit card for monthly service. The Splash is rated IPX7, and can be submerged in up to 3ft of water for up to 30 mins. Fall Detection is an optional feature. Fall Detection may not always accurately detect a fall. GreatCall is not a healthcare provider. Seek the advice of your physician if you have questions about medical treatment. 5Star or 9-1-1 calls can only be made when cellular service is available. 5Star Service will be able to track an approximate location when your device is turned on, but we cannot guarantee an exact location. Monthly service fee does not include government taxes or assessment surcharges, and is subject to change. GreatCall and 5Star are registered trademarks of GreatCall, Inc. Copyright ©2016 GreatCall, Inc.

© PARADE Publications 2016. All rights reserved.

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60", 4 DRAWER HARDWOOD Customer Rating WORKBENCH LOT 69054/93454 62603 shown

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• 100% Satisfaction Guaranteed • Over 30 Million Satisfied Customers

29%

$375

$63.88 with other discount 800-423-2567. Cannot be used while supplies last. good or HarborFreight.com or by calling LIMIT 5 - Good at our stores after 30 days from original purchase with original receipt. Offer per customer per day.

9/8/16. Limit one coupon or coupon or prior purchases must be presented. Valid through Non-transferable. Original coupon

• No Hassle Return Policy • Lifetime Warranty On All Hand Tools

$

54999 comp at

R PE ON SU UP CO

$999

TRIPLE BALL TRAILER HITCH LOT 61914/61320 shown

SAVE 77%

LOT 62469 62337 shown

comp at

LOT 68530/63086 63085/69671 shown LOT 68525/69677 63087/63088 CALIFORNIA ONLY

LIMIT 3 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

$4499 $4999

99

LIMIT 4 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

3-IN-1 ELECTRIC BLOWER VACUUM MULCHER SAVE

¥ 76 dB Noise Level

$69.99

WOW SUPER COUPON Customer Rating

SAVE $449

2999

comp at

SAVE $235

$

8750 PEAK/ 7000 RUNNING WATTS 13 HP (420 CC) Customer Rating GAS GENERATORS

SUPER QUIET

SAVE 57%

$ 99 comp at

$29.99

LIMIT 5 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

LOT 66783/60581/62334 60653 shown

LOT 68496/61363 68497/61360 68498/61359

5

LOT 95588/60561 69462 shown

$19.48

POWDER-FREE NITRILE GLOVES PACK OF 100 SIZE MED LG X-LG

Customer Rating

SAVE 70%

R 12 VOLT, 10/2/50 AMP PERON PE ON Customer Rating BATTERY CHARGER/ SU UP SU UP O C ENGINE STARTER CO

Item 68498 shown

3 PIECE DECORATIVE SOLAR LED LIGHTS

20"

R PE ON SU UP O C

Customer Rating

5999 comp at

LIMIT 4 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

Tools sold separately.

$

$144.10

LIMIT 8 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

¥ 5 mil thickness

Customer Rating

SAVE $84

$599 $899

with other discount 800-423-2567. Cannot be used while supplies last. good or HarborFreight.com or by calling LIMIT 7 - Good at our stores after 30 days from original purchase with original receipt. Offer per customer per day.

9/8/16. Limit one coupon or coupon or prior purchases must be presented. Valid through Non-transferable. Original coupon

SAVE 89% $ 99 $

comp at

LIMIT 5 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

179$49999

4" x 36" BELT/ 6" DISC SANDER

$17.97

$7654 $

R PE ON SU UP O C

METRIC

SAE

LOT 69043 42304 shown

¥ 580 lb. capacity

11999

R PE ON SU UP CO

73

$

comp at

LIMIT 5 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount LIMIT 3 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last. or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day. Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

SAVE

$15999

VALUE

26", 4 DRAWER TOOL CART

LOT 61258 shown 61840/61297/68146

SUPER COUPON

339

LIMIT 3 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

Customer Rating

LIMIT 4 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

SAVE

$

$ 98

ANY SINGLE ITEM

Limit 1 coupon per customer per day. Save 20% on any 1 item purchased. *Cannot be used with other discount, coupon or any of the following items or brands: Inside Track Club membership, extended service plan, gift card, open box item, 3 day parking lot sale item, compressors, floor jacks, saw mills, storage cabinets, chests or carts, trailers, trenchers, welders, Admiral, Badland, CoverPro, Daytona, Diablo, Franklin, Hercules, Holt, Jupiter, Predator, Stik-Tek, StormCat, Union, Vanguard, Viking. Not valid on prior purchases. Non-transferable. Original coupon must be presented. Valid through 9/8/16.

LOT 61282 shown 68049/62326 62670/61253

$159.99

LOT 69091/61454 61693/62803/67847 shown

LOT 65020/69052 shown 69111/62522/62573

R PE ON SU UP O C

2500 LB. ELECTRIC WINCH WITH WIRELESS REMOTE CONTROL

SUPER Customer Rating COUPON 2.5 HP, 21 GALLON 125 PSI VERTICAL AIR COMPRESSOR

3-1/2" SUPER BRIGHT NINE LED ALUMINUM FLASHLIGHT

$58.55

SAVE $90

WOW

WITH ANY PURCHASE

LIMIT 5 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount LIMIT 4 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last. or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day. Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

R PE ON SU UP O C

SUPER COUPON

$ Customer Rating

1999

comp at

$89.99

LIMIT 3 - Good at our stores or HarborFreight.com or by calling 800-423-2567. Cannot be used with other discount or coupon or prior purchases after 30 days from original purchase with original receipt. Offer good while supplies last.

Non-transferable. Original coupon must be presented. Valid through 9/8/16. Limit one coupon per customer per day.

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