Abstract OE01
CHANGE OF REAL-TIME ULTRASOUND STRAIN ELASTOGRAPHY IN PATIENTS WITH GRAVES’ DISEASE. KUN-YO LAI, FENG-HSUAN LIU, SHU-FU LIN, SZU-TAH CHEN Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou,Taiwan
Objective: The purpose of this study is to detect the change of tissue stiffness of patients with Graves’ disease (GD) before and after treatment with real-time ultrasound strain elastography (SE) technique. Methods: A total of 67 subjects (54 women and 13 men) with Graves’ disease, aged from 16 to 68 (42.73 ± 11.74) y/o were enrolled for strain elastography examination. They were divided into hyperthyroid (n = 39) and euthyroid (n = 28) groups in this study. Two measurements of elastic modulus values, i.e. liver fibrosis index (LFI) and strain ratio, were performed in the cross-sectional view, strain ratio was obtained by comparing with the ipsilateral sternocleidomastoid muscle. Thyroid function tests including T4, TSH, and TSH receptor antibody (TRAB) were detected in all patients. Independent sample t-test, logistic regression, Pearson’s correlation and receiver operating characteristic (ROC) curve were applied for statistical analysis. Results: The elastic modulus value of LFI in hyperthyroid and euthyroid groups ranged from -1.0 to 2.06 (mean 0.49 ± 0.77) and -0.72 to 3.23 (mean 1.05 ± 1.14), p < 0.05, respectively. Patients with higher LFI showed lower risk of hyperthyroidism (OR: 0.53, 95% CI, 0.31-0.92); in contrast, patients with lower LFI showed higher risk of euthyroidism (OR: 1.87; 95% CI: 1.08-3.24). LFI was also found to be negatively correlated with T4 (r = -0.26), TRAB(r = -0.28) and hyperthyroidism (r = -0.28) in GD, all p < 0.05. The area under the curve of ROC (AUC ROC) of euthyroidism evaluated by LFI was 0.63, with the best discrimination point of value of 0.85 (sensitivity 57.1% and specificity 69.2%). In addition, TRAB displayed positive correlation with T4 (r = 0.40, p < 0.001) and hyperthyroidism (r = 0.40, p < 0.001); age showed positive correlation with LFI (r = 0.39, p < 0.01) and strain ratio (r = 0.31, p < 0.05). No correlation was found between strain ratio and T4, TSH or thyroid function status. Conclusion: LFI of strain elastography correlates with thyroid function status in GD patients. In addition, TRAB and age could influence thyroid stiffness of GD.
129
