Annual report 2013 by Karolinska Institutet

Annual Report 2013

A medical university

(Dnr 1-583/2013) Karolinska Institutet is one of the world’s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

COVER PHOTO Aula Medica was officially opened in 2013, but plans for a large lecture hall at Karolinska Institutet started far back. In 2001, Gert Wingårdh Architects won the assignment to design a lecture hall complex for KI, but the project was put on hold due to financial reasons. The building of Aula Medica was made possible six years later through a donation of 350 million SEK, made by the Erling-Persson Family Foundation. The construction started in September 2010 and the building was completed in June 2013. Aula Medica consists of an auditorium called Erling Perssonsalen with capacity for 1,000 people, offices for about 100 people, 100 conference seats, restaurants, a faculty club and a café. Photo: Ylva Sundgren

A MEDICAL UNIVERSITY

VICE-CHANCELLOR’S STATEMENT Vision and overall objectives

Photo: Ylva Sundgren

Following my first year as Vice-Chancellor of Karolinska Institutet (KI), I am convinced that we can make a vital contribution to improving human health. However, this vision can only be realised if KI’s research achieves scientific breakthroughs and results in discoveries that change our view of not only health and disease, but also normal vital processes. It is important that as many of the results of our research as possible have practical applications in healthcare and that they lead to innovations. The objective of our study programmes is to provide students with the best possible preparation to critically assess and continually incorporate new knowledge into their professional practice so that they are able to lead and develop their work in collaboration with other professions and disciplines.

Strong international position KI is one of the world’s leading medical universities, which has recently been recognised in two international rankings of universities and university colleges. Our university has favourable financial resources at its disposal and modern, growing infrastructure at the forefront of technology. We have benefited from a positive research policy climate in Sweden, strong growth, a successful fundraising campaign, robust infrastructure and an increase in industrial collaboration. Ahead of 2013, three key issues concerning KI’s development and future were identified: to strengthen KI’s position as a leading international research university, to improve the quality of its study programmes and develop its collaboration with healthcare.

Research initiatives A specific initiative has been launched to recruit additional leading international professors and visiting professors, as a complement to the corresponding initiative from the Swedish Research Council. One of our goals is to increase the proportion of female professors as soon as possible, and to this end support is now paid to departments that recruit women as professors and visiting professors. We are also concentrating on the recruitment of exceptionally promising young researchers. Central funding has also been set aside for new postdoctoral research fellows and researchers with the aim of strengthening the career structure for junior researchers.

The quality and research basis of our study programmes This year, a wide-ranging investigation has been set up, under the leadership of the Pro-Vice-Chancellor, into the quality and

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Chancellor Anders Hamsten in Karolinska Institutet’s Aula Medica, which was inaugurated on 11 October 2013. The Aula building was realised thanks to a donation from the Erling-Persson Family Foundation and was given its unique character by the architect Gert Wingårdh. research basis of our study programmes. If we are to raise the quality of our Bachelor’s and Master’s study programmes, we must improve these links as well as the organisation and incentive structure. The main questions are how to establish an effective connection between research and education that is educationally enriching, how to achieve an optimal education organisation that clarifies the departments’ educational responsibilities, and how the government appropriation can be used to secure the research basis of our study programmes and our subject expertise, and to enable the creation of attractive posts and career paths for teachers. The investigation presents a number of proposals for strengthening KI in these respects and my intention is to ensure that many of the proposed measures start delivering results this year. When our students leave KI, we want them to have received the best possible preparation for their continuing professional development in a quickly-changing labour market.

University healthcare In our increasingly fragmented healthcare landscape, it is imperative that research and education has full access to wellorganised, high-quality healthcare. Consequently, the development of KI’s strategy for collaboration with the healthcare sector was given high priority over the past year. Two particularly important issues involved establishing the content of our activities in the new Karolinska University Hospital and setting

A MEDICAL UNIVERSITY

the criteria for university healthcare (i.e. the part of the healthcare system in which KI places both research and education). Furthermore, KI has pushed for the development of value-based healthcare, in which the value of care to the patient is measured and rewarded in ways that support innovation, quality and sound nursing practices. We have also helped to establish an effective, quality-assured medical information service and to devise quality-promoting remuneration systems. A specific Deputy Vice-Chancellor post has been created to further strengthen KI’s representation in collaborations on future healthcare provision.

Corporate alliances The global pharmaceutical industry has dramatically changed its strategic course and is now looking across a broad front for closer collaborative ties with, in particular, the medical faculties. Success in such collaboration is dependent on the university taking an active role in converting the results of research into practical applications; the ability to innovate grows in significance. In 2013, KI entered into an agreement with AstraZeneca to build a unique joint research centre for cardiovascular and metabolic diseases, which will be located in KI’s southern campus. Researchers from KI will work side by side with colleagues from AstraZeneca under the leadership of a joint director appointed by KI. The agreement sets a budget of approximately SEK 650 million over a five-year period.

Aula Medica, Gamma and the Widerström Building An historic event took place on 11 October with the ceremonial opening of Aula Medica. With its large lecture theatre and spacious stairwells and lobbies, Aula Medica is a functional and stimulating meeting place for science, debate and academic ceremonies. It is hoped that the beautiful, open design of the auditorium will inspire innovative ideas and discussions that challenge the prevailing scientific paradigms. Also opened in 2013 were the Gamma block, which has enabled the expansion of SciLifeLab and accommodates our commercial activities, and the Widerstöm Building, home to the Department of Learning, Informatics, Management and Ethics and the Department of Public Health Sciences.

Donations KI received a number of donations in 2013, which have made vital contributions to our research. I would like to extend my particular gratitude to the following: • Karin and Sten Mörtstedt (CBD Solutions AB), allergy research • The Bertil Hållsten Research Foundation, Hållsten Academy Fellows • Mattias and Sonia Westman, research and development in cognitive neuroscience • Investor, professorship in innovative health and social care • Märit and Hans Rausing, breast cancer research as part of the KARMA project

• The Einhorn Family Foundation, research collaboration with Makerere University, Uganda • Gunnar and Ingmar Jungner’s Foundation, the AMORIS project.

Need for new powers of decision-making The ministerial memo concerning the introduction of a new academic organisational form – the University Foundation – was the cause of much lively debate in the autumn of 2013. KI appreciates the government’s intention to increase the autonomy of educational institutions and specifically emphasised in our statement of opinion the areas in which changes would significantly affect our international competitiveness. These areas include KI’s opportunity to: • accept and freely utilise donated funds, • build up equity, • own, acquire and dispose of its own companies, and create foundations, • own, acquire and dispose of real estate, • establish and run international operations, • be allowed to use a certain proportion of the research appropriation for activities that promote innovation, • provide a certain degree of healthcare in order to create specific education- and research-intensive environments.

Strategy 2018 The work to produce our strategy for the period 2014–2018 began in the autumn. In this document, we uphold the overall objectives for KI’s research and education and the fundamental aspects of the strategies that have been chosen to achieve these objectives. A critically important choice is whether KI will seriously endeavour to improve its international competitiveness in terms of cutting-edge research, recruitment, large grants and its ability to attract infrastructure investments. Consequently, the focus is placed on recruitment and career development, the internal allocation of resources and incentive structures, organisation and leadership, infrastructure, university healthcare, international, national and industrial collaboration and innovations. Great challenges – and opportunities – lie ahead of us. We still seek effective preventive measures for the disabling, prevalent diseases, methods of their early diagnosis, and knowledge of their innermost molecular mechanisms – this last being essential for individualised and thus more effective and, hopefully, curative treatment. Success in tackling these challenges will require scientific breakthroughs made by enthusiastic, creative, brilliant and hardworking colleagues. I have high expectations for the future of KI and would like to thank all of our staff and students for the sterling efforts they have made over the past year.

Anders Hamsten

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

A MEDICAL UNIVERSITY

A WORD FROM THE STUDENTS

Erik Hellsing, President, Medical Students’ Association in Stockholm 2013

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

and the self-evaluations conducted prior to the Swedish Higher Education Authority’s reviews, provided a good picture of the programme’s strengths and opportunities for improvement. In the future, the student unions will, together with KI, actively use these evaluations to improve courses and educational programmes at KI. Internationalisation has also been an important topic this past year. The work that has begun to increase the internationalisation of educational programmes and the plans to build housing for international students, are important first steps in encouraging students from all over the world to choose KI over other top universities. However, the student unions see that further vigorous efforts to improve quality of educational programmes and the educational environment must be made in order to maintain and develop KI’s status as an internationally competitive university. The participation of the student unions in the processes relating to the continual monitoring of courses and educational programmes and student representation at KI highlights topical issues and makes them accessible to all students. This not only increases the quality of the end-product, but also gives the students a greater involvement in KI as they have a hand in shaping the KI that they themselves will work in or with in the future, when today’s students become the health care professionals of the future.

Photo: Fredrik Pajala

Photo: Ulf Sirborn

In 2013, the collaboration between the student unions, the Medical Students’ Association in Stockholm (MF) and the Student Union of Odontology (OF), and KI increased, a collaboration which all benefited from. MF and OF were given the task of welcoming the new Vice-Chancellor with a film at his installation ceremony. The message, an increased focus on quality of education, student housing and campus issues, was submitted to the new management, with the unexpected side benefit of improved interactions between the student unions. Furthermore, increased cooperation with KI was intensified by means of a more comprehensive approach to the reception of new students. MF and OF therefore hope, that the future holds an even closer cooperation with KI on student and campus issues. The past year was one in which several organisational issues were brought up for discussion. The government’s proposal concerning university college foundations called for profound discussions in KI’s board and senior management concerning KI’s future organisational structure. The executive group also began working on a vision for KI for the period up to 2018. This work which continues into 2014 and will then be merged with the project looking at the educational programmes’ quality and their links to research. In the discussions concerning KI organisational structure, the size of KI’s range of courses and educational programmes has also been high on the agenda. The analyses of the programmes, combined with the question of size

Hampus Eksell, President, Student Union of Odontology 2013

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

ANNUAL REPORT 2013 VICE-CHANCELLOR’S STATEMENT . . ........................................................................................................................................ 3 A WORD FROM THE STUDENTS . . ............................................................................................................................................ 5 ABOUT KAROLINSKA INSTITUTET.......................................................................................................................................... 8 BACHELOR’S (FIRST-CYCLE) AND MASTER’S (SECOND-CYCLE) EDUCATION. . .............................................................. 11 DOCTORAL ( THIRD-CYCLE) EDUCATION............................................................................................................................ 21 RESEARCH. . ............................................................................................................................................................................... 25 KI IN SOCIETY – COLLABORATION AND INNOVATION. . .................................................................................................. 35 COMMON TO THE ENTIRE ORGANISATION Provision of expertise and equal opportunities................................................................................................................................................. 41 Infrastructure................................................................................................................................................................................................................. 45 Sustainable development.......................................................................................................................................................................................... 46 FINANCIAL REPORT................................................................................................................................................................ 47 Notes................................................................................................................................................................................................................................ 61 INTERNAL CONTROL.............................................................................................................................................................. 71 THE UNIVERSITY BOARD.. ...................................................................................................................................................... 72 KEY INDICATORS..................................................................................................................................................................... 76 APPENDIX COSTS.................................................................................................................................................................... 77 TABLES APPENDIX................................................................................................................................................................... 79

Figures in the tables provided in this annual report have been rounded up, so that the totals, etc., do not appear consistent.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

A MEDICAL UNIVERSITY

KAROLINSKA INSTITUTET IN BRIEF Karolinska Institutet (KI) is a modern medical university that is responsible for about 40 per cent of the academic medical research in Sweden and which has the largest range of medical courses and study programmes in the country. KI’s close connections with healthcare, extensive infrastructure and strong finances allow KI to conduct education and research of the highest quality. A compilation of factual information about KI is provided in the section Key Indicators.

KI’s commission and governance KI’s commission has its basis in the Higher Education Act, which states that the university’s role is to offer courses and study programmes based on research and proven experience and to conduct research and development. The university is also required to collaborate with society at large and disseminate information about its activities. The following performance report is based on the university’s commission as set out by the Government in the Higher Education Act and the public service agreement. Academic freedom, firmly established in law, provides extensive space for independent research and education. KI has only one faculty, medicine. New procedural regulations for KI, stipulating the overall organisational structure, how decision making powers are delegated, how cases are managed and the shape of other activities, have been drawn up and come into force on 1 January 2014. KI’s governance model means that the Board make budget decisions concerning the organisation as a whole and the Vice-Chancellor then makes decisions about further allocation of resources and annual duties based on the strategies and focus areas that have been adopted. In financial year 2013, KI has begun the work to shape Strategy 2018, which will be settled in spring 2014. The strategy builds on previous strategy documents and aims to clarify the key questions and challenges that will be of significance to sustainability, continuity and renewal.

Organisation

Karolinska Institutet’s structure 2013

THE UNIVERSITY BOARD

Internal Audit

VICE-CHANCELLOR

Board of Higher Education University Administration Board of Doctoral Education

University Library

Board of Research Comparative medicine Councils and Committees KI Holding AB

Department of Biosciences and Nutrition Department of Cell and Molecular Biology Department of Clinical Neuroscience Department of Clinical Science and Education, Söder Hospital Department of Clinical Science, Danderyd Hospital Department of Clinical Sciences, Intervention and Technology Department of Dental Medicine Department of Environmental Medicine Department of Laboratory Medicine Department of Learning, Informatics, Management and Ethics Department of Medical Biochemistry and Biophysics Department of Medical Epidemiology and Biostatistics Department of Medicine, Huddinge Department of Medicine, Solna Department of Microbiology, Tumour and Cell Biology Department of Molecular Medicine and Surgery Department of Neurobiology, Care Sciences and Society Department of Neuroscience Department of Oncology-Pathology Department of Physiology and Pharmacology Department of Public Health Sciences Department of Woman and Child Health

Research and education is conducted primarily at the campuses in Solna and Huddinge. Karolinska University Hospital is connected to the campuses and has a vital role in clinical research and education. Collaboration also takes place with other hospitals in the local area.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

A MEDICAL UNIVERSITY

Karolinska Institutet carries out its research and education at several campus areas and at a number of the county hospitals. The majority of students are given most of their education at the campus in Huddinge. Campus Solna 1,709 FTE students 1,634 million SEK for research 1,990 FTE employees Campus Huddinge and Karolinska University Hospital, Huddinge 3,074 FTE students 904 million SEK for research 1,081 FTE employees Danderyd Hospital 241 FTE students 25 million SEK for research 22 FTE employees Söder Hospital 186 full-year students 42 million SEK for research 41 FTE employees Karolinska University Hospital, Solna 756 FTE students 1,280 million SEK for research 1,149 FTE employees

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Photo: Ulf Sirborn

A MEDICAL UNIVERSITY

New management. Vice-Chancellor Anders Hamsten, Pro-Vice-Chancellor Kerstin Tham and University Director Per Bengtsson. Per Bengtsson assumed his duties on 1 January 2014. In 2013 Bengt Norrving was University Director.

Infrastructure Together with Akademiska Hus, KI is undertaking a huge investment in new buildings and modern premises in order to better meet the needs of research and education. When the plans for Hagastaden and a new, ultra-modern university hospital took shape, this became an opportunity for KI to realise its plans for the Campus Solna. It is important, not least, to benefit from the collaboration and efficiency opportunities offered by the new university hospital. The hospital becomes the universityâ&#x20AC;&#x2122;s closest neighbour in Solna and the plan is to link the hospital building to university buildings including Aula Medica, which was completed in 2013, and the future research laboratory Biomedicum. The infrastructure will provide better conditions for modern medical research, which requires, to an ever greater extent, access to expensive, advanced equipment. This should be accessible to many researchers and shared to make it cost-effective.

Quality assurance Constantly improvement is the basis of the work to raise quality at KI. A prerequisite for success is to integrate this work into day-to-day activities. Quality requirements are set out in various policy and strategy documents. This year, a wide-ranging investigation into the study programmesâ&#x20AC;&#x2122; quality and research basis has been set up. The main issues under consideration have been a more effective connection between research and education that enriches study programmes, with an optimised educational organisation and use of Direct government funding. The investigations proposals will be considered over the course of 2014.

10â&#x20AC;&#x2021;

The ongoing work with internationalisation activities within KI is of key significance for quality assurance and to strengthen the position as a leading international research university. The measures are aimed at improving quality, competitiveness and diversity in research, education and administration. KI has a long-established tradition of international connections and academic exchanges with researchers, teachers and students.

Innovation and collaboration KI has been developing an innovation system for several years in order to ensure that health and medical care reaps the benefits of medical and health innovations. The innovation system currently consists of several stakeholders providing services that all aim to realise the benefits of ideas generated from research. KI has collaborative research and education agreements with a range of prominent universities from around the world and also works with companies in the biomedical and biotechnology sectors, as well as directly with individual countries. As a medical university, it is very important for KI to collaborate with health and medical care, in particular with Stockholm County Council (SCC). Our shared objective is to conduct research and education of an internationally high standard for the benefit of current and future patients. This is done through the continual professional development of healthcare staff and the implementation of the results of research. Decisions are made on overall strategies for education, research and infrastructure in joint steering groups in order to make the KI/SCC collaboration effective. KI is developing tests for pharmaceuticals and medical products together with the industry.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

ETT MEDICINSKT UNIVERSITET

On the way to lectures. Students pass through the so-called Winter Garden between the Jöns Jacob restaurant and the Karolinska Institutet University Library at the campus in Solna. In the background, the “small cottages” are visible – seminar rooms which give students a greater opportunity to study individually and in groups.

BACHELOR’S AND MASTER’S EDUCATION

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Photo: Andreas Beronius

BACHELOR’S (FIRST-CYCLE) AND MASTER’S (SECOND-CYCLE) EDUCATION

BACHELOR’S AND MASTER’S EDUCATION

BACHELOR’S (FIRST-CYCLE) AND MASTER’S (SECOND-CYCLE) EDUCATION Range of courses and study programmes Karolinska Institutet (KI) offers a wide range of courses and study programmes in medicine and healthcare. This wide range is unique in Sweden. This year, KI offered over 40 study programmes and around 80 freestanding courses at Bachelor’s (first-cycle) and Master’s (second-cycle) level. The range is weighted towards study programmes that lead to a professional qualification as well as continuing education for those who already have an education within healthcare. KI aims to offer an increased proportion of Master’s courses and study programmes in subjects linked to the university’s strong research areas. All courses and study programmes, regardless of their level, must have a distinct research basis in order to provide the prerequisites of evidence-based practice. According to current labour market forecasts for the years ahead, there will be a great demand for the professions educated at KI. There is also a great need for continuing professional development for various healthcare professions. KI works together with healthcare and other employers when planning the range of courses and study programmes and when deciding on their content.

In recent years, work on the range of courses and study programmes has focused on long-term adaptation to the funding cap. For example, KI has phased out two beginner’s study programmes and reduced the number of freestanding courses. Furthermore, KI has worked to create economic conditions that are favourable to its role of delivering high quality education. Consequently, KI has reduced the number of programmes that do not have admissions each academic year. There have been few new initiatives this year, but the new master’s programme Public Health in Disasters, which is an Erasmus Mundus programme, has begun (see also the section Internationalisation). KI’s study programmes are primarily campus based, with the exception of certain specialist nursing programmes, while freestanding courses are more often offered as distance education. According to the public service agreement, KI must organise professional status qualification courses for unregistered opticians. KI assessed that there was no identifiable need to start such a course in 2013. The tables below show the distribution of full-time equivalent students (FTEs) between study programmes and freestanding courses and between the Bachelor’s and Master’s education.

Distribution between programmes that lead to professional qualifications, programmes that lead to general qualifications and freestanding courses 2010–2013 2010

2011

2012

2013

FTEs

General qualification – Bachelor’s

264

248

211

197

General qualification – Master’s

393

443

424

417

3,726

3,832

3,976

4,334

Professional qualification – continuation

566

582

573

580

Freestanding courses

575

709

701

488

5,524

100

5,815

100

5,885

100

6,014

100

Professional qualification – beginner

Total

Distribution of courses between Bachelor’s and Master’s education 2010–2013 2010

2011

2012

2013

FTEs

Bachelor’s

3,423

3,480

3,554

3,701

Master’s

2,035

2,289

2,290

2,267

Unclassified Total

5,524

100

5,815

100

5,885

100

6 ,014

100

Source: Ladok.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

BACHELOR’S AND MASTER’S EDUCATION

Students Number of applicants per place by programme type (qualified first-choice applicants) 2010 Places

2011

Applicants/

Places

place

Beginners Continuation (excl. Master’s) Master’s Total

2012

Applicants/

Places

place

2013

Applicants/

Places

place

Applicants/ place

1,142

5,1

1,297

4,6

1,245

4,9

1,238

5,4

511

2,9

618

3,1

674

2,8

674

2,8

334

2,9

362

1,9

325

2,3

385

2,4

2,087

4,1

2,277

3,8

2,244

3,9

2,297

4,2

Source: VHS, NyA, Open.

Applicants

Student influence

KI’s study programmes generally have a high acceptance ratio and it has increased compared to 2012. The number of qualified first-choice applicants increased for the majority of study programmes. The total increase was nine per cent. The majority of KI’s study programmes have more than two qualified firstchoice applicants per place. The number of qualified first-choice applicants for the psychology programme increase by 43 per cent – to 9.4 applicants per place. Among the Master’s study programmes, a continued increase in the number of applicants for master’s programmes in English can be noted.

The students’ participation is an important condition of KI’s development. Students at all levels have the opportunity to exert their influence in KI’s planning and decision-making bodies. In order to increase the student influence further, KI has established a special collaborative group consisting of student representatives and KI’s executive management. The group meets regularly. To achieve a quorum, bodies that have a direct responsibility for educational matters must have at least one student representative present, provided one has been appointed. KI organises annual training for students active in KI’s planning and decision-making bodies. Students are educated on applicable laws and provisions as well as on KI’s organisational and decision-making structure. KI has an agreement with the two student unions at the university regarding their responsibility for student influence and educational monitoring. KI provides financial support for this, as well as for the students’ ombudsmen. In 2013, 63 per cent of student representatives in decisionmaking bodies (KI’s Board, the internal executive boards and programme committees) were women, an increase of five percentage points compared with 2012. Seventy-three per cent of the student body are women.

Widening participation KI’s efforts to widen its recruitment involves both recruiting new groups of students and creating good study conditions for those who are already studying at the university. In 2013, KI offered students individual supervision in academic writing in Swedish. In a pilot project, KI has also offered language supervision in English. Students have the opportunity to receive this supervision both on campus and remotely. KI organised a series of seminars on academic writing. The number of study programmes taking advantage of these seminars has increased compared to the previous year. As one method of widening its participation, KI uses student ambassadors who visit upper secondary schools in Stockholm County to present KI. KI strives for as diverse a group of ambassadors as possible, both in terms of gender and ethnicity. Inspirational lectures and study visits have been undertaken at the three upper secondary schools that KI cooperates with in Huddinge, Solna and Tensta. Another important part of efforts to widening participation is that KI offers prospective students the opportunity to ”shadow a student”.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

BACHELOR’S AND MASTER’S EDUCATION

Education Full-time equivalent students (FTEs) and annual performance equivalents (APEs) In 2013, the number of FTE students within the framework of the funding cap was 5,885 and the number of APEs 5,307. This is an increase in the numbers of both FTEs and APEs compared with 2012. This result is higher than predicted, mainly due to the completion rate being higher than estimated. The result for 2013 was SEK 30.4 million above the funding cap (direct government funding for Bachelor’s and Master’s education) after remuneration for APEs from December 2012. Each programme’s share of the total number of FTEs is illustrated in the diagram below. The number of FTEs and APEs in the various programmes is shown in Table 4 of the Tables Appendix. FTE students at KI in 2013 (total 5,885) Freestanding courses 8 %

FTE students in the study programme in medicine and the study programme in dentistry According to the public service agreement, KI must report the total number of FTE students on the study programmes in both medicine and dentistry. This information appears in the table below. Table 3 in the Tables Appendix shows how the number of FTEs has changed over time.

Total number of FTE students on the Study Programme in Medicine and the Study Programme in Dentistry 2013 Study Programme in Medicine

1,591

Study Programme in Dentistry

412

Source: Ladok.

Master programmes 7 % Medicine 26 %

Other continuation programmes 2 % Specialist nursing (continuation) 8 % Biomedical lab science 3 %

Physiotherapy 6 % Other beginner’s programmes 11 % Nursing 13 %

KI’s study programme in psychology started in the autumn semester of 2007 with 40 places through the reallocation of resources. KI has gradually been allocated 30 Bachelor’s places via public service agreement and the programme thus has 70 places. In the autumn semester of 2013, 85 students were registered for semester 1.

Degrees

Occupational therapy 4 % Dentistry 7 %

Admissions to the study programme in psychology

Psychology 5 %

Source: Ladok.

The estimated remuneration for the year’s activities amounts to SEK 631.1 million after remuneration of the performances from December 2012 of SEK 2.2 million, SEK 633.4 million is debited from the direct government funding for 2013. This results in an direct government funding saving of SEK 19.4 million being carried forward.

Remuneration for FTEs and APEs within the funding cap 2010–2013* (SEK millions) 2010

2011

2012

2013

Funding cap

619,4

616,1

589,2

603,0

Remuneration

553,8

588,0

599,0

633,4

Under/over funding cap

-65,7

-28,2

11,2

30,4

The total number of degrees awarded has increased compared with 2012. The increase is due to factors including a reduction in the effect of the cancelled admissions to the study programme in nursing as the first intake from the new study programme took their degrees this year. This has an impact on the number of degrees of bachelor of science in nursing and degrees of bachelor of nursing. The number of master’s degrees has increased by 86 per cent due to the specialist study programme in nursing programme at KI now leading to a general qualification as well as a professional qualification. The number of degrees awarded is shown in Table 5 in the Tables Appendix. Some of KI’s study programmes lead to both a general and a professional qualification. The number of individuals who have achieved degrees is thus lower than the total number of degrees awarded.

* Including supplementary direct government funding for the period 2010–2011. Sources: Ladok, public service agreement.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Photo:Ulf Sirborn

BACHELOR’S AND MASTER’S EDUCATION

Graduation ceremony. Vice-Chancellor Anders Hamsten congratulates students who recently graduated from the study programme in medicine, at a graduation ceremony in January 2014. This was the first graduation ceremony to be held in the Erling Persson auditorium in Aula Medica, inaugurated in October 2013.

Revenue from commissions distributed by source of funding 2013

Number of degrees awarded 2010–2013 Degree

2010

2011

2012

2013

Professional qualifications

1,416

1,466

1,223

1,256

728

773

655

891

Total number of degrees

2,144

2,239

1,878

2,147

Total number of individuals

1,786

1,888

1,668

1,758

General qualifications

Source: Ladok.

Foreign 10 %

Swedish companies 11 %

Other government agencies 27 %

Organisations and foundations 3%

Higher education institutions12 %

Commissions KI’s commissions consists of contract education and contracted courses. Revenue from commissions amounted to SEK 61.4 million in 2013, a decrease of 12.3 percent on the figure for 2012. One explanation for this reduction is the end of the Swedish National Board of Health and Welfare’s investment in psychiatry in 2012.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Source: Agresso. Contract education.

County councils and municipalities 37 %

BACHELOR’S AND MASTER’S EDUCATION

Student exchanges 2013

Number of incoming students to Karolinska Institutet

Number of outgoing students from Karolinska Institutet

ASIA NORTH AMERICA EUROPE

194

74 17

AFRICA SOUTH AMERICA

7 26

Internationalisation

Internationalisation of KI’s courses and study programmes at the Bachelor’s and Master’s level education is conducted in accordance with an established action plan. The goal is for KI graduates to have the ability to work in both multicultural environments and an international labour market with varying economic and social conditions. KI should also be an attractive study destination for international students. KI strives to increase teacher exchange and has thus introduced temporary grants for week-long exchanges to countries where there is a lack of external funding. In future, the Linnaeus-Palme Programme will also contribute to more extensive teacher exchange on the condition that applications are approved. It is gratifying that the number of teachers interested in exchange opportunities have increased compared with 2012, from 23 to 30. KI currently participates in three Erasmus Mundus programmes, focusing on India, South Africa and Europe. Erasmus Mundus is an EU-funded mobility and academic cooperation programme run by consortia. In 2013, KI was granted funding

OCEANIA

for the master’s programme Public Health in Disasters, together with the University of Oviedo, Spain and Université Catholique de Louvain, Belgium. The programme began in autumn 2013 and will lead to a joint degree awarded by KI and the University of Oviedo. KI has continued to arrange information meetings about teacher and student exchanges, social activities for participating teachers and students and courses on teaching in English. The number of outgoing exchange students from KI has increased compared with 2012. The study programme in medicine is responsible for the largest increase. In addition, a number of KI students complete part of their degree project abroad each year, outside of exchange programmes. Students who participate in international courses such as Global Health and Medical Development in Europe and the EU also undertake part of their education abroad. Compared to recent years there is a net reduction in exchange students, due to fewer incoming students from abroad. The largest reduction is in the number of students from Europe coming to KI. Table 6 in the Tables Appendix shows how student exchange has changed in recent years.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

BACHELOR’S AND MASTER’S EDUCATION

Tuition fees for students from a third country KI had a total of 94 fee-paying students in 2013. This year, KI offered seven master’s programmes and a number of freestanding courses taught in English on which tuition fees were payable. Thirty-seven new fee-paying students were registered on KI’s master’s programmes in the autumn semester of 2013. Fifteen of these had a full scholarship. In addition, ten students were registered on freestanding courses. Finally, eight students were admitted to the master’s programme Public Health in Disasters. These students’ will commence their studies at KI in the spring semester of 2014. The total number of FTE students amounted to 51 and the number of APEs to 50 in 2013. KI demonstrates continuing strong results in the International Student Barometer 2012/13, which measures students’ satisfaction with the quality of their education and reception services. The investments that KI has made as part of its tuition fee-funded operations – e.g. the development of an English language website – benefit all of the university’s internationalisation efforts and educational activities. Tuition-fee funded operations involve a certain increase in administration. The cost of this is funded by the tuition fees. In 2013, KI had 75 third-country students within the scope of exchange agreements, compared with 80 students the previous year. Because of the introduction of tuition fees, no new strategic agreements have been signed with universities outside the EU/EEA area. Collaboration with the Swedish Migration Board has been satisfactory, with the exception of a few cases where the third-country student’s residence permit was delayed despite having paid the tuition fee. There has also been a lack of clarity concerning residence permits for students who have been admitted to courses that are worth less than 30 credits. The proportion of third-country students in semester 1 of master’s programmes taught in English has increased compared with 2012 and operations funded by tuition fees have generated a surplus for the first time. This is mainly due to an increase in the number of fee-paying students. See tables below.

Third-country students in semester 1 of master’s programmes taught in English 2011–2013 2011 Proportion registered (%)

14,3

2012 15,1

2013 21,5

Source: Ladok.

Quality

Investigation of study programme’s quality and research basis Over the course of the year, KI has investigated how the quality of study programmes can be improved. The investigation looks at issues concerning how KI can create an enriched connection between research and education, make posts attractive to teachers and optimise the organisation of study programmes. The final report, containing proposed measures, is presented at the beginning of 2014.

Review of degree project courses and degree projects In 2012, KI initiated a review of degree project courses in order to ensure that the degree projects undertaken by KI’s students maintain a satisfactory and consistent standard. The results were presented in January 2013. A total of 56 degree project course syllabi were reviewed in the first phase of the project. The syllabi were reviewed in relation to the objectives in the Higher Education Ordinance. Eighteen per cent of the syllabi were judged to conform strongly to the objectives in the Higher Education Ordinance, 41 per cent had both strong and insufficient conformity and 41 per cent insufficient conformity. Ninety-four randomly selected degree projects were reviewed in the second phase of the project. The assessment used the criteria for the review of degree projects at KI, complemented by the objectives for the assessment of possible fulfilment of degree project objectives. Fifty-one per cent of the degree projects were judged to be of a high quality, and 49 per cent of an insufficient quality. The management of the departments has been informed of the results and have been challenged to revise the affected course syllabi. In cases where the degree projects themselves have been judged to be weak, the departments have been challenged to make changes to, for example, how students are supervised.

The Swedish Higher Education Authority’s evaluations In spring 2013, the Swedish Higher Education Authority reviewed about 30 degrees awarded by KI. The reviews covered degrees including Bachelor of Science in Nursing, Bachelor’s and Master’s degrees in nursing, ten specialist nursing degrees, Master of Science in Medicine and Master of Science in Dental Surgery. The nine degrees for which KI has received the results so far have been judged of a high quality.

Revenue and costs for operations funded by tuition fees 2011–2013 (SEK millions) Revenue

2011

2012

1,7

5,7

2013 9,3

Costs

3,6

5,9

7,6

Total

-1,9

-0,2

1,7

Source: Agresso.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

BACHELOR’S AND MASTER’S EDUCATION

Investigation of the opportunities to coordinate and improve anatomy teaching

Equal opportunities

In 2013, KI investigated the opportunities of establishing an anatomy centre. The aim is to improve the quality of anatomy teaching by increasing its clinical relevance, deepening its progression and supporting interprofessional learning in KI’s study programmes. Another aim is to offer the county council’s staff clinical professional training to support the work of improving quality and patient safety in healthcare. The investigation indicates that it would be beneficial to coordinate anatomy teaching, but certain issues must be investigated further before a final decision can be made.

Most of KI’s Bachelor’s and Master’s programmes have a uneven gender distribution, where men are in the minority. It is only the study programme in medicine that has a relatively even gender distribution. It is difficult to affect gender-linked vocational choices; a similar pattern can be seen at other universities offering healthcare education and in the labour market the students will encounter following graduation. In total, the changes are small compared to 2012, but differences can be seen at the programme level. For example, the proportion of men commencing the study programme in optometry has increased, from 15 per cent to 25 per cent, as has the proportion of men commencing the study programme in psychology, from 35 to 41 per cent. In order to affect gender-linked educational choices, KI, for example, always use representatives of both sexes in its marketing to prospective students.

Measures to improve the quality of placements This year, KI has worked to improve the quality of placements. One project involves deviation reporting. Many of KI’s students’ future jobs will involve deviation reporting. Therefore, KI, in collaboration with Stockholm County Council, is investigating whether students can be given the opportunity to practice this in placements. The project also aims to assure the quality of placements through offering students the opportunity to report deviations affecting planning and supervision. The project’s final report will be published in 2014. Further information can be found under Commission to develop clinical education and research.

Measures to improve the quality of educational activities Support function for educational activities and IT In 2013, KI has coordinated its educational support functions though the establishment of the Centre for Learning and Knowledge (CLK). The centre’s main tasks are to provide educational support to the development of courses and study programmes and to support the use of information and communications technology in education. It has four focus areas: learning and IT, educational development, physical learning environments and evaluation. Teaching courses and continuing professional development In 2013, twelve courses in teaching and learning in higher education took place, involving a total of about 300 teachers. The university has also organised a teachers’ day focusing on the development of educational IT support for teachers. One hundred and twenty teachers, clinical supervisors and students took part in the teachers’ day. Online courses In 2013, KI entered into an agreement with the international education group edX, making it possible to offer online courses, known as massive open online courses (MOOC), to hundreds of thousands of students around the world. Working with edX raises KI’s profile, contributing to an increased national and international recruitment base. Initially, four courses will be offered by KI in the autumn semester of 2014. One long-term goal is for the collaboration with edX to contribute to establishing KI as an institution that sets the tone of the growing global education market.

Gender distribution

Equal opportunities in teaching Over the course of the year, KI has worked to improve the equal opportunities perspective in its courses and study programmes. Examples of areas in which equal opportunities have been dealt with in courses and study programmes are issues concerning the approach to patients and students’ future professional roles. Equal opportunities are also dealt with in courses covering fields in which there is a connection between different patient groups and disease prevalence. In 2013, the study programme in optometry has carried out a project one of the aims of which is to improve students’ approach to patients and prepare them for the risk of being called into question. In order to improve students’ social environment in terms of equal opportunities, the study programme in occupational therapy has introduced a system of peer social support. The aim is to support new students as they begin their university studies. In addition, all new students are informed about the discrimination legislation and about the support services available at KI. The social environment of students is monitored in the course evaluations. Improved knowledge and awareness among placement supervisors is vital to promoting equal opportunities in courses and study programmes. Therefore, KI offers its teachers and clinical supervisors training in these issues. The university’s new online courses in equal opportunities and discrimination have also been used to improve knowledge among administrative staff and teachers. KI also offers training to the students, primarily with regard to the Discrimination Act and equal opportunities perspectives in education.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Photo: Camilla Svensk

BACHELOR’S AND MASTER’S EDUCATION

Occupational therapists in the making. Anders Nylund and Helene Gustafsson, both reading to become occupational therapists, studying together in Karolinska Institutet’s university library in Huddinge.

Gender distribution of those commencing Bachelor’s programmes, 2013

Gender distribution of those commencing Master’s programmes, 2013

Occupational therapist

Midwifery

Audiology

Psychotherapy

Biomedicine

Specialist nursing

Biomedical laboratory sciences

Odontological prophylactics

Speech pathology and therapy

Master’s 1 year Master’s 2 year

Medicine

Total

Optometry

Psychology Radiology nursing

Source: Ladok.

20%

40% Men

60%

80%

100%

Women

Physiotherapy Nursing Dental hygiene Dentistry Total 0% Source: Ladok.

20%

40% Men

60%

80%

100%

Women

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

BACHELOR’S AND MASTER’S EDUCATION

Integration Supplementary training for doctors, nurses and dentists from third countries Together with the universities of Lund, Gothenburg and Linköping, KI has been commissioned to provide supplementary training for individuals from third countries who have completed a degree in medicine, dentistry or nursing. KI organises study programmes that each encompass one year of full-time studies (60 credits). The number of applicants, registrered and graduated students, as well as the number of full-time equivalent students in supplementary training are shown in the Table 7 of the Tables Appendix.

Commission to develop clinical education and research In 2013, KI was allocated SEK 1.6 million for the development of clinical education and research. KI decided to use these funds for clinical research. In 2013, there has been a large focus on the provision of placements as the need for placements is increasing and it is of the utmost importance to maintain the quality of these places. It is primarily nursing and specialist nursing programmes that have, at certain times, a hard time finding sufficient placements. One way to create additional places of high quality is educational continuing professional development, which is why KI have offered courses, seminars and workshops this year. In 2013, the efforts to produce an evaluation tool for placements resulted in a report. From the three pilot projects undertaken in 2013, it has become clear which parts of placement are of a high standard and which need to be improved. The collaboration between universities and hospitals and the structure of educational tasks and learning objectives are examples of areas that need to be improved. The most important result of the pilot studies is that high quality placements are founded on good supervision. Consequently, a guide for supervisors has been produced, describing the student’s path through the placement. A further initiative aimed at improving quality is for each student to – during the first part of their placement – undergo an obligatory online course in journal management, approach to patients, privacy and hygiene.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

DOCTORAL EDUCATION

Pipetting in the laboratory. Ingrid Lilienthal is a doctoral student at the Department of Cell and Molecular Biology. Lilienthal is in professor Camilla Sjogren’s research group and is studying how cells transfer information from one generation to the next, with a special focus on how cells repair damage that occurs during the process. KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Photo: Linda Lindell

DOCTORAL (THIRD-CYCLE) EDUCATION

DOCTORAL EDUCATION

DOCTORAL (THIRD-CYCLE) EDUCATION Doctoral (third-cycle) education is an important aspect of the work of Karolinska Institutet (KI). KI continues working to ensure that the best doctoral students are recruited. All doctoral studentships where KI is the primary employer must be advertised and recruited through open competition. This takes place, for example, through a collective advertisement four times per year. Interest in doctoral education at KI is high. There are an average of 64 applications for every advertised place. However, the number of doctoral students admitted decreased to 373 in 2013, compared with 438 the previous year. KI will continue to focus on research schools, particularly those targeted at doctoral students with a clinical background. KI has 13 research schools for doctoral students, as well as summer research schools for upper secondary school pupils and Bachelor students. KI has recently been awarded a grant from Vinnova, Swedish Governmental Agency for Innovation Systems, to develop a research school for ”drug development and discovery”. The aim of this research school is to train the next generation of researchers in pharmaceutical development and to promote collaboration between the pharmaceutical industry and the university. KI works continuously to improve the quality of doctoral education by developing the range of courses offered through, for example, online courses, various survey tools such as a poll for doctoral students who have completed their midway review and an exit poll for doctoral students when they publicly defend their thesis. The surveys ask questions about supervision, courses, working environment and support from departments and the university administration. In order to ensure that all doctoral students have a good working environment, the Board of Doctoral Education has visited each of the departments over the course of 2013.

Results

Over the course of the period 2010–2013, admissions of new research students have decreased by 17 per cent. This downward trend has escalated in financial year 2013. The main reason behind this reduction is the increased costs associated with the new regulations in the Higher Education Act that students must be funded for at least one year if they receive an educational grant and three years’ if they are employed on a doctoral studentship. The reduction in the total number of admissions coincides with a reduction in the proportion of women (from 62 per cent in 2010 to 55 per cent in 2013), an increase in the proportion with foreign qualifications (from 33 per cent in 2010 to 37 per cent in 2013) and an increase in the proportion who are young (39 per cent under 30 in 2010, 48 per cent in 2013). The definition of an active doctoral student has changed as a result of new tools for the production of statistics. Active doctoral students in 2013 are defined as those doctoral students who at the end of 2013 had been admitted to doctoral education, had not yet taken their degree and had reported an activity of 10 per cent or more in the autumn term. This new definition has also been applied to the period 2010–2013. The new method results in a somewhat smaller number of doctoral students than the previous method. The date of the dissertation (or licentiate seminar) was previously used as the date of their degree. Since 1 November 2012, doctoral students must apply for their degree and the date of their degree is thus subsequent to the date of their dissertation. In practice, this means that some of those who publicly defended their thesis in 2012, only received their degree certificate in 2013 and the figures that arise in the transition between the two systems are not completely comparable. The obvious reduction in the number of doctoral degrees awarded in 2013 thus does not necessarily reflect a real reduction.

Doctoral education: admissions, registered students and degrees awarded 2010–2013 Doctoral admissions – of which licentiates _ Registered doctoral students (active >10%)

2010

2011

2012

2013

450

409

438

373

2,002

2,045

2,111

2,090

Licentiate degrees

Doctoral degrees

367

349

359

306

– of which have a licentiate degree Source: Ladok.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

DOCTORAL EDUCATION

Number of doctoral degrees awarded at KI 2010–2013

Costs of doctoral education

Number

The average cost of a doctoral student employed on a doctoral studentship/educational grant has been estimated at SEK 1,198,000, which is almost the same as the previous year. The cost is based on various assumptions and must therefore be regarded as approximate.

400

300

Cost per performance indicator for doctoral students 2012–2013 (SEK thousands)

200

2012

2013

153

158

Operating costs

Premises

240

246

100

Supervision costs Salaries 0 2010 Male

2011

2012

Female

2013 Total

Depreciation Subtotal

Active doctoral students at KI 2010–2013

Doctoral student costs

Number

Salaries/educational grants

327

323

2 500

Operating costs

256

251

Premises

143

159

Subtotal

772

775

Indirect salary and operating costs

178

177

1,190

1,198

2 000

Depreciation

1 500

Total costs

1 000

Source: Agresso and Primula.

500

Quality 0 2010

2011

Male

2012

Female

Recruitment of doctoral students

2013

In 2013, about 30 per cent of new doctoral students were recruited through the posts being advertised, an increase of 10 percentage points on the previous year. The average number of applicants per advertised doctoral post was 64, with a distribution between 21 and 155.

Total

Source: Ladok.

Actual period of study 2006–2013

The actual period of study has remained for the most part unchanged in relation to the last three years and is somewhat above the norm for the past four years. Year 4 3 2 1 0

2006

Source: Ladok.

2007

2008

2009

2010

2011

2012

Dissertation

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

2013

Doctoral students’ working environment In order to perform well, doctoral students need a good, safe working environment. Work to improve poor environments for doctoral education and to reduce the exposure of individual doctoral students is ongoing. Each of the 22 departments has been visited in 2013 to monitor them and discuss these issues. These discussions have been deemed constructive and many departments have either begun or intensified their efforts to improve doctoral students’ working environments as a result. Beginning on 1 July 2013, all doctoral students must be offered a meeting with the department’s director of studies following the completion of their first year. The director of studies can in this way become aware of and deal with any problems at an early stage. In addition, this meeting allows the doctoral student to learn about the director of studies’ role and function.

Photo: Ulf Sirborn

DOCTORAL EDUCATION

Researchers and doctoral students. Stefano Caramuta, postdoc, Adam Andreasson, postgraduate and Linkiat Lee, postdoc, are members of professor Catharina Larsson’s research group at the Department of Oncology-Pathology.

Monitoring and examination Sweden has a system in which almost all doctoral students pass their examination. In order to ensure that all those who publicly defend their thesis have achieved the quality objectives that are expected, KI has developed a system for monitoring them during their education involving, for example, the midway review, annual monitoring and prospective review of the work that forms part of their doctoral thesis. KI has not previously evaluated the actual quality of the examination and thesis. In spring 2013, an anonymous survey of members of the Examination Board was therefore conducted which included questions about the doctoral student and the quality of the thesis. Over 60 per cent indicated that the thesis has a good or very good academic quality. Only one person was hesitant about whether it was appropriate to award a pass to the doctoral student. One specific area for improvement was identified as the thesis’ summary. This year, a webinar (online seminar) has been produced to support the doctoral degree learning objectives and to act as a tool when examining these. This is accessible via internwebben.

Internationalisation New exchange agreements for doctoral students

This year, a short-term doctoral student exchange agreement was signed between the Chinese University of Hong Kong and KI. This agreement means that one or two doctoral students per year from one university can spend up to six months at the other. KI has also signed a doctoral exchange agreement with the

University of Helsinki. These exchanges will last for at least one month and take place within the scope of ongoing research collaboration between the two universities.

National Institutes of Health Since 2001, KI has had an established doctoral student collaboration in the field of neuroscience with the National Institutes of Health (NIH) in the USA; the largest institutionalised collaboration involving doctoral education at KI. Doctoral students divide their time between KI and the NIH and have supervisors from both organisations. In 2013, three new doctoral students were recruited to joint research projects.

Equal opportunities Since 2010, a section on equal opportunities has been included in the mandatory introduction for all newly admitted doctoral students. Supervisor training, which is mandatory for new supervisors, also includes courses on gender equality issues and equal opportunities. A large proportion of KI’s doctoral students do not speak Swedish. Consequently, regulations and guidelines that are important and relevant to doctoral students and supervisors are published in both Swedish and English. A review of the information about doctoral education revealed that a large proportion is published in both languages. Additional equal opportunities measures that affect research and doctoral education are described in the section Continuing Professional Development and Equal Opportunities.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

RESEARCH

Photo: Linda Lindell

Microscopy. Sidney Carter-Dewey is a postdoc at the Department of Cell and Molecular Biology, where he is in professor Camilla Sjögren’s research group.

RESEARCH KAROLINSKA INSTITUTET ANNUAL REPORT 2013

RESEARCH

RESEARCH The objective is for Karolinska Institutet’s (KI’s) research to take a leading position in Europe, with comparable activities at leading European universities constituting a yardstick. This ambition and the ensuing activities have been developed based on a careful analysis of the state of research in Sweden and at KI. A number of different initiatives have been launched. KI has mobilised financial resources for the recruitment of leading international professors, visiting professors and young researchers. KI needs to have more female professors to achieve a better gender balance and to act as role models for young female researchers. It has been decided to provide special activity support to departments that successfully recruit female professors and visiting professors. One career path for young researchers, encompassing research assistant (two years), a further post following research assistant (two years) and a post as researcher (five years), has been established. Within the scope of the collaboration between KI and Stockholm County Council, research funding has been made available for investments in high-quality basic, translational and clinical research at Campus Huddinge. These funds must be advertised and awarded competitively and should be used in a very forceful way to develop research in the region. Other major issues have been mobilisation and activities within the scope of KI’s large infrastructure projects. KI’s strengths have been gathered together to build trusting relationships with leading universities around the world. Several close collaborations have been initiated with large international pharmaceutical companies. The largest such initiative is a new cardiometabolic research centre at KI that has been built in collaboration with AstraZeneca, who will in full fund the centre with SEK 650 million over five years.

New research findings – some examples As a medical university, KI conducts research into a broad spectrum of subjects covering all types of diseases. The research is carried out at all levels, from purely experimental laboratory research that maps the origin and development of diseases, to more patient-oriented treatment research and clinical trials. Here is a selection of new findings that have been published in prestigious academic journals over the past year.

Cancer An EU collaboration, led by KI, identified over 80 genetic ”spelling mistakes” that have an impact on the risk of breast, ovarian and prostate cancer. In addition, it is possible to calculate how many other genetic variants probably have an impact on the risks of developing these diseases and where in the genome

you should look in future studies (five publications in Nature Genetics, March). One study showed that women who are treated with radiotherapy for breast cancer have an increased risk of myocardial infarction later in life. The risk increased most for women who had other known heart disease risk factors such as smoking, high BMI or diabetes (New England Journal of Medicine, March). The survival rate for patients with Hodgkin’s lymphoma has improved considerably in recent decades and a new study has shown that the majority of deaths among these patients are not now related to the disease. The huge improvement is considered to be the result of changes to treatment, primarily the transition from radiotherapy to chemotherapy (Journal of Clinical Oncology, February). Surgery is the most well-established curative treatment for oesophageal cancer, but the operation is extensive and only one in three patients is still alive five years after their treatment. A recent study showed that patients who undergo surgery have a significantly higher chance of long-term survival if the operation is performed by a surgeon who often performs the same type of operation (Journal of Clinical Oncology, January). A method for assessing the effectiveness of breast cancer treatment has been presented. This method involves tracking the changes in the density of the breast – the part that is white on a mammogram – while treatment is ongoing (Journal of Clinical Oncology, April). Every year, about 700 teenagers in Sweden lose a parent to cancer. A study of children’s experiences of healthcare showed that their confidence that their parent had received the best possible care was highest in cases where the family had taken part in an informative discussion prior to death (Journal of Clinical Oncology, July).

Obesity As part of an international research consortium, it has been demonstrated that obesity is itself the cause of cardiovascular and metabolic diseases, and not just a marker of another underlying cause (PLoS Medicine, June). Studies of overweight and obese women showed that their children have an increased risk of being born prematurely (Journal of the American Medical Association, June) and that this increased risk persists, even after the mother has undergone obesity surgery (British Medical Journal, November).

Heart disease A Swedish study showed that patients with heart failure have a high mortality rate and are often not treated sufficiently. It was also seen that many of these patients require access to advanced

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

RESEARCH

Photo: Lennart Nilsson/TT

specialist care. Patients with these needs could be identified simply by looking at five common risk factors (Journal of the American College of Cardiology, October). Two studies concerning heart stem cells have been presented that attracted a lot of attention. The first demonstrated a marker that is required for the development of stem cells in the left ventricle (Nature Cell Biology, July). The other described a new technique in which synthetic messenger RNA (mRNA) that codes for VEGF-A is injected into the muscle cells. The study, which was conducted on mice, showed that there only needs to be a single pulse of VEGF-A to stimulate heart stem cells to develop, provided this pulse can be delivered to the exact place in the heart where the stem cells are located (Nature Biotechnology, September).

Infectious diseases and vaccination A follow-up of possible side-effects in girls in Sweden and Denmark who have been vaccinated against human papilloma virus (HPV) could not show any statistical increase in any of 53 diagnoses among the vaccinated girls (British Medical Journal, October). An extensive registry study showed that prevalence of genital warts decreased by 93 per cent in girls who had been given the HPV vaccine prior to the age of 14 (Journal of the National Cancer Institute, March). Testing for HPV when screening for cervical cancer has been compared with analyses of cell samples and the results showed that HPV screening provides 60–70 per cent better protection against invasive cancer (Lancet, November). Urinary tract infections are one of the most common diseases, primarily in postmenopausal women. A study of postmenopausal women showed that oestrogen stimulated their bodies’ own antibiotic and strengthened the mucous membrane in the urinary tract, which indicates that local oestrogen treatment can help women to fight recurrent infections (Science Translational Medicine, June).

Rheumatoid arthritis and psoriasis New biologically active drugs to combat rheumatoid arthritis have been developed in recent years. A study of drug combinations supported existing treatment recommendations (Lancet, October). Another study showed what are known as epigenetic changes in the genome to be involved in the genesis of rheumatoid arthritis. This improves our understanding of how risk genes can have an impact on disease and why certain individuals are affected to a lesser extent than others (Nature Biotechnology, January) Knowledge about how the disease psoriasis develops has improved now that a new cellular mechanism has been described (Immunity, November).

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

A femur damaged by rheumatism.

Epilepsy Unexpected death causes by sudden cardiac and respiratory arrest is a common cause of death among those with severe epilepsy. New knowledge about the disease’s background and symptoms has been produced, which may form the basis of better treatment and monitoring recommendations (Lancet Neurology, September). An epidemiological study showed that a high proportion of deaths among epileptic patients were the result of external causes such as suicide, accidents and drug misuse (Lancet, July). Improved knowledge of these, often mental health-related, causes among healthcare professionals would help prevent a greater number of deaths.

Psychiatry Research into the underlying causes of schizophrenia took a big step forward thanks to the mapping of 13 new genetic variants that increase the risk of schizophrenia (Nature Genetics, August). A study, which looked at 1.6 million births in the Nordic countries, showed that treatment of a pregnant woman with SSRI antidepressants does not increase the risk of foetal or infant death (Journal of the American Medical Association, January). It was previously known that there was an increased risk of the child suffering other side-effects, at the same time as there are well-known risks of leaving depression untreated in pregnant women.

Photo: Linda Lindell

RESEARCH

Collaboration. Research group leader Teresa Frisan in a discussion with her postgraduate students, Riccardo Guido and Laura Levi. They are working at the Department of Cell and Molecular Biology, where they are studying the underlying reasons for why certain chronic bacterial infections increase the risk of cancer. An international research collaboration showed that there is a link between treatment for male infertility – known as ISCI, involving the sperm being injected directly into the egg – and a somewhat increased risk of autism and intellectual disability in the child (Journal of the American Medical Association, July).

Brain and nervous system A national follow-up study of children born very prematurely (before week 27) showed that by 2.5 years of age, 73 per cent had a minor or no functional disability, with the figure improving for each week of pregnancy (Journal of the American Medical Association, May). The hippocampus is a part of the brain that is involved in memory and learning. A study showed extensive generation of new nerve cells in the hippocampus in adults – something that had previously been debated (Cell, June). A study showed that scar tissue that is formed from stem cells following a spinal injury does not have a detrimental effect on the recovery of function, rather it prevents the damage becoming more extensive (Science, November). Coordination of muscle activation in the legs when we walk can be compared to the coordination of the different instru-

ments in an orchestra. Researchers identified the nerve cells and nerve branches in mice that regulate walking tempo and control the ability to alternate between moving the right and left leg (Nature, June and Neuron, November).

Ageing When we age, our cells change and become damaged. New discoveries, which improve our understanding of the ageing process, have shown that it is not just the damage that accumulates over the course of an individual’s life that is significant, but also the genetic material inherited from their mother via her mitochondrial DNA (Nature, August). Genetic changes that cause calcium deposits in the brains of both mice and humans have been discovered (Nature Genetics, August). This condition, which increases in frequency with age, caused motor, cognitive and psychiatric problems.

Pharmaceuticals A research group has been able to improve the cytostatic treatment given to children with the chronic immune deficiency disorder granulomatous disease prior to a stem cell transplant. By using tailor-made doses of cytostatics ahead of the transplant,

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

RESEARCH

they achieved increase survival with minimal side-effects for the patients. (Lancet, October). A study showed that treatment with cortisone preparations increases the risk of acute pancreatitis, which is the most common disease of the pancreas. The results indicate that patients treated with certain forms of cortisone should be informed about the risks and also told to abstain from alcohol and smoking (JAMA Internal Medicine, February). The first method that makes it possible to directly measure whether drugs have reached the correct target in the cell was presented. This method is significant to the development of new pharmaceuticals (Science, July).

Cell biology research A previously unknown mechanism that controls whether a cell dies or survives autophagy, a process that can be compared to the cell eating up parts of itself, has been described. This discovery can open up new opportunities to affect this process, which is involved in a large number of different diseases (Nature, July). The discovery that two different species of salamander use different ways to make their muscles grow back in lost body parts was presented. The discovers of the species-specific solutions shows that there is not just one, but many mechanisms to recreate tissue (Cell Stem Cell, November) A five-year follow-up of the first successful transplant of an tissue-engineered trachea indicated good results. The patient, who was operated on in 2008, has a good quality of life and has not been affected by rejection reactions to the implant (Lancet, October)

Molecular biology at the Science for Life Laboratory With the help of a new analytical method, close to one hundred new protein-coding regions of the human genome have been found. A number of these are what is known as pseudogenes, which are thought to be linked to cancer (Nature Methods, November). Every time a cell divides all of the transcription factors are released from the DNA and the specific binding pattern that provides the cell with its identity must be restored when the division is complete. How this happens has not previously been explained; however, researchers have now, for the first time, shown how a protein ring that encircles the DNA acts are the cell’s memory (Cell, August). The genome of the Norway spruce was mapped as part of the world’s largest genetic project. The research is based on technological and methodological development that has been judged to be of great significance to medical research (Nature, May) Researchers have successfully deduced a significant proportion of the proteins that control the genetic expression of various DNA sequences. This knowledge dramatically improved

our understanding of how human genes are regulated and is vital to interpreting individuals’ genomes and understanding the individual risk of developing different diseases (Cell, January).

New methods in molecular biology A new method for measuring the activity of genes in individual cells was presented (Nature Methods, December). A better technique for measuring the activity of genes in individual cells was presented, which may be significant to fundamental research and future diagnosis (Nature Methods, September). A new way to manufacture short, single-stranded DNA molecules was also described (Nature Methods, June).

Quality Measures of academic output – bibliometrics KI uses bibliometrics to measure the dissemination and impact of its research findings. Bibliometrics involves the application of mathematical and statistical methods to articles, books and other communications media. Reported data1 will be reviewed over a long period of time. The number of published articles is a rough measure of academic output and depends on a variety of factors, such as the publication patterns of different disciplines. The bars of the figure below represent published articles with addresses that have an affiliation to KI. Figures for the number of published articles are based on year of publication2. Because there is a slight delay to the database being updated, complete statistics for the past year are not available at the time the annual report is published. Therefore, details for 2013 are not reported so as to provide a true and fair view of developments. Number of published articles 2003-2012 6 000 5 000 4 000 3 000 2 000 1 000 0 2003

2004

2005

2006

2007

2008

2009

Other

Editorial Material

Review

Letter

Meeting Abstact

Article

2010

2011 2012

Source: Web of Science. ®

Certain data included herein is derived from the Web of Science® prepared by THOMSON REUTERS®, Inc. (Thomson®), Philadelphia, Pennsylvania, USA: © Copyright THOMSON REUTERS® 2013. All rights reserved. 2 The main addresses included in the analysis are: Karolinska, Huddinge Hospital/Sjukhus, Danderyd Hospital/Sjukhus, Sodersjukhuset/Soder hospital, St Goran Hospital/Sjukhus, St Erik Hospital/Sjukhus, Ersta Univ Coll, Sophiahemmet Coll, Astrid Lindgren. 1

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

RESEARCH

A more accurate view of academic output can be obtained by comparing the figures over a longer period of time. KI chooses to compare the years between 2003 and 2012. Over the course of this period, the total number of published articles increased by 40 per cent. This figure reflects a steady increase in the volume of activity and forms the background to the quality analyses below.

Field normalised citation score The field normalised citation score reflects the number of citations the article has compared to other articles of the same type, i.e. the same type of document from the same year and the same subject. An individual article’s indicator is 1 if it is cited as many Field normalised citation score 2003–2012 Citation score 1,75 1,50 1,25 1,00 0,75

2003 2004 2005

2006

2007 2008

2009

2010 2011

2012

Research documentation To simplify the keeping of research documentation, maintain its high quality and ensure traceability, KI is making an electronic logbook, KI-ELN, available to all researchers. Implementation is ongoing and the system was used by about 2,100 people in October 2013. The paper logbook that was used previously is available in parallel to the electronic logbook.

Research based education Support for research links is provided through three investments totalling SEK 37.5 million: providing funds for very educationally active teachers, the establishment of a ”future faculty” programmes (twelve lecturers specifically focused on teaching and temporarily part-funded) and the commissioning of subject advocates (not yet implemented). One of the aims of linking education to research is to get those active in research at the highest level to participate in teaching at the Bachelor’s and Master’s education. Students at these levels may then go one to doctoral education and participate actively in research projects. In spring 2013, the Vice-Chancellor set up an investigation into our study programmes’ quality and research basis led by the Pro-Vice-Chancellor.

Research funding

times as the average number for similar articles. The diagram below shows the average value of the field normalised citation score for all articles from KI, distributed by year. This figure has been relatively stable, with KI maintaining its position compared to the rest of the world. Published articles from 2013 cannot be considered to constitute the basis of stable and reliable results and have been excluded from the report.

Total research funding continues to rise. The direct government funding has increased by 11 per cent since 2010, while external funding has increased by eight per cent. There have particularly notable increases in funding from the Swedish Research Council (VR), a 15 per cent increase from 2012 to a total of SEK 678 million, and from the Wallenberg Foundations, a 39 per cent increase to a total of SEK 129 million. In addition to project grants, VR approved framework direct government funding for research into infection and antibiotics, ageing and health, register-based research, for research collaborations with China, grants for large databases and grants for prominent young researcher and several research schools. In the

Career paths for researchers

Change in research funding 2004–2013

Global average

Source: Web of Science. ®

Recruiting and holding onto the most prominent researchers is necessary if KI position as a leading international research university is to be strengthened. In order to highlight these issues, KI arranged a workshop, with about 50 participants, about career structures for teachers and researchers. A combined programme for the central calls for proposals for funding for the recruitment of successful researchers at various junior levels has been worked out. The current levels are research assistant, research assistant extension (researcher limited to two years) and researcher limited to five years. To complement these initiatives, a programme for central investments in the recruitment of certain strategic professor and visiting professors post has been worked out. The candidates must also be of particular value and benefit to KI.

SEK Million 3 500 3 000 2 500

External

2 000 1 500 Government

1 000 500 0 2004

2005

2006

2007

2008

2009

2010

2011

2012

2013

Source: Agresso.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

RESEARCH

Total research revenue 2010-2013 (SEK millions) Funding source

2010

2011

2012

2013

Change 2012–2013 (%)

Foundations and organisations

654

688

692

779

12,6

Foreign sources of funding (see below)

496

431

417

435

4.6

Research councils

597

654

730

800

9.6

Municipalities and county councils

551

427

475

396

-16.5

Other government funding

260

298

349

344

-1.4

Swedish companies

196

171

168

182

8.3

21.4

KI funds Financial income

-30.5

Total external funding

2,824

2,792

2,937

3,040

3.5

Direct government funding

1,581

1,630

1,732

1,763

1.8

Total

4,405

4,422

4,669

4,802

2.9

Proportion of external funding (%) Source: Agresso.

Total revenue from foreign sources of funding 2010–2013 (SEK millions) 2010

2011

2012

2013

Change 2012–2013 (%)

231

224

194

-0,0

Foundations and organisations

195

128

150

158

5.3

16.4

496

431

416

437

5.0

Companies Total Source: Agresso.

Swedish Research Council’s (VR’s) large call for proposals, KI was granted the largest amount of any university, amounting to SEK 553 million over the next five years. KI was also awarded large multi-year grants from the Knut and Alice Wallenberg Foundation, KAW, including SEK 175 million for six different research projects, SEK 35 million for the development of toxicology infrastructure and SEK 22.5 for a careers programme focused on young researchers.

Revenue from the EU (including scholarships) 2004–2013* SEK Million 250 200 150 100 50 0

European Union KI is the largest recipient of EU grants of all Swedish institutions, and one of the largest in Europe in the field of health. A total of 229 projects at KI were funded by the EU in 2013. The revenue from these, excluding scholarships, amounted to SEK 194 million, which is the same as the previous year. Five new projects supported by the European Research Council (ERC) were started in 2013. At the end of 2013, there were 27 ERC projects at KI. KI has further reinforced its position with regard to the number of excellent researchers in ”bottom-up” projects, where the subject of the research is decided by the researchers themselves. The level of involvement in excellent research constellations in ”top-down” projects, where the subject of the

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 EU

Scholarships

* Due to new accounting principles that began in 2011, scholarships are specified separately in the chart above for the years 2011–2013. Source: Agresso.

research is decided by the EU, has been maintained in comparison with the previous year.

European support for individual researchers European grants for individual researchers mainly come from the ERC and the Research Executive Agency (REA). The ERC is one of the parts that make up the EU’s framework programme

RESEARCH

for research funding, Seventh Framework Programme for Research (FP7), and will also be part of the new framework programme, Horizon 2020. The ERC provides support to individual researchers for ideas that have the potential to revolutionise their particular field. Three of the four ERC Starting Grants for life sciences that were allocated to Sweden went to KI. The corresponding figure for Advanced Grants was two. KI has eleven current ERC Advanced Grants and fifteen Starting Grants. In 2013, revenue from ERC research grants amounted to SEK 58.9 million, which corresponds to an increase of 14.8 per cent compared to 2012. The Marie Curie Programme encompasses both individual and network-based forms of support, with a common aim to reinforce Europe’s intellectual capital and competitiveness. In 2013, there were 28 individual grants to researchers at KI, a reduction of eight grants.

per cent compared with the previous year. KI has obtained government research grants from the National Institutes of Health, the Agency for Healthcare Research and Quality, the US Army and the National Science Foundation, but budget cuts have had a negative impact on these (SEK 14 million, -33 per cent). However, this has been compensated for by a sharp increase in revenue from other American organisations (SEK 53.1 million, +43 per cent).

Funds for strategic research areas

At the start of 2013, European collaborative projects at KI were funded by both the framework programme (FP7) and the European Commission and pharmaceutical industry’s joint initiative, Innovative Medicines Initiative (IMI). KI has participated in 229 EU projects in 2013. KI coordinates 19 of these. KI took on the role of coordinator for three new projects in the latest FP7 calls for proposals. KI is the largest single recipient of funds from the EU’s health programme in Sweden. KI participates as a partner in thirteen of the 41 current IMI projects, coordinating one of these. At the beginning of the programme, the calls for proposals for funding for collaborative projects as part of FP7 (2007–2013) were well in line with the areas in which KI is strong. This is why a larger number of the projects were also coordinated by KI at the beginning than at the end of the funding period. KI has successfully participated as a partner in multidisciplinary, translational projects towards the end of FP7. These types of collaborative projects will play an increasingly large role in the new framework programme Horizon 2020, when KI’s crossdisciplinary and industrial contact network will be an asset.

Six research environments in diabetes, neuroscience, care sciences, cancer, epidemiology and stem cells/regenerative medicine have been established with strategic research funding (SFO). The objective of every SFO environment is to develop its respective research field and to improve the connection between preclinical research, clinical research and industry. Strategic research funding amounted to SEK 137.2 million in 2013. The development of the SFO environments and synergies with other strategic initiatives provide KI with a strong base on which to shape its profile as a leading international research centre in each of the fields. KI participates in two additional SFO initiatives in molecular biosciences (SciLifeLab) and E-science. This year SciLifeLab has been reorganised and consists partly of a national resource, led from KTH Royal Institute of Technology Royal Institute of Technology, and partly direct government funding and a local pooling of resources from KI, KTH Royal Institute of Technology, Stockholm University and Uppsala University. SciLifeLab’s national focus makes it possible for researchers from both KI and the rest of Sweden to access modern instruments for technically demanding and large-scale research projects focussing on studies into the function of genes and proteins. SciLifeLab works to create natural collaborative platforms, together with other established national infrastructures, for example CBCS, Biobanking and Molecular Resource Infrastructure of Sweden (BBMRI.se) and SWEDSTRUCT. There is more information about SciLifeLab in the sections Collaboration and Infrastructure.

Research grants from the USA

Funds for strategic infrastructure

KI is one of the largest European recipients of research grants from the USA. The university’s revenue from American funding sources amounted to SEK 67.1 million in 2013; an increase of 16

Led by KI, several Swedish universities have worked together to establish a national centre, Swetox, for research and education in toxicology and related sciences. The centre is located in Gärtuna

European collaborative projects

Number of EU projects 2008–2013* Total number of projects - with KI as coordinator**

2008

2009

2010

2011

2012

2013

260

230

204

222

234

229

* Number of current projects within FP6, FP7 and the Health Programme. Decided on, but not yet started are not included. In 2013, there were no active FP6 projects. ** The figures referring to KI as coordinator do not include projects supported by the European Research Council (ERC). Source: EU database KI.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

RESEARCH

in Södertälje, with the initial construction financed with funds from FORMAS, KAW and KI. In autumn 2013, the Swedish National Facility for Maneto Encephalography (NatMEG) was opened, this resource is part of the Swedish network for biomedical imaging, Swedish Bioimaging. For some time, KI has coordinated other parts of the national infrastructure with basic funding from VR and addition funding from collaborative partners. The role of Chemical Biology Consortium Sweden (CBCS) is to offer researchers large-scale studies of how molecules bond to various target proteins. Biobanking and Molecular Resource Infrastructure of Sweden (BBMRI.se) aims to create a national standard for the collection of biobank samples, along with cost-effective opportunities for long-term storage and the analysis of samples. BBMRI.se is supported by all of the medical universities in Sweden and different units will be established at various locations throughout the country. Swedish Infrastructure for Integrated Structural Biology (SWEDSTRUCT) works to create cohesive infrastructure for structural biology.

International Neuroinformatics Coordinating Facility (INCF) The INCF was established by the OECD in August 2005 for the purposes of developing the field of neuroinformatics (databases and computer modelling) and facilitating the development of different types of standards and other infrastructure. Neuroinformatics is a separate part of bioinformatics that is very significant to the development of knowledge about the function of the nervous system and its psychiatric and neurological diseases. The INCF has 17 member countries in Europe, North America, Australia and Asia, and is financed through fees related to the countries’ investments in research and development. The INCF secretariat has 14 employees, primarily post-doctoral researchers. KI provides premises and administrative services to the INCF and KTH Royal Institute of Technology provides a professorship in neuroinformatics and a post at the Centre for High-performance Computing (PDC). In 2013, the INCF has worked in the following programmes: Digital Brain Atlasing; Ontologies for Neural Structures; Multiscale Modelling; and Standards for Data Sharing. The overall aim of the programmes is to create global neuroinformatics standards and interoperability. The INCF has also developed INCF Dataspace, software that can be used in the development of neuroscience databases. Dataspace is a part of the international cyberinfrastructure for neuroinformatics, one of INCF’s primary functions. More than 150 leading international researchers are involved in the INCF’s activities.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Internationalisation Internationalisation efforts at KI aim to improve quality and diversity of our research, education and administration in order to improve the university’s competitiveness. KI has a long tradition of international contacts and academic exchanges with researchers, teachers, and students in other countries. The map on opposite page provides an overview of international collaborations in terms of the number of joint publications with different countries. The number of academic articles published by Karolinska Institutet’s researchers in collaboration with one or more researchers from each country or territory.

The University of Texas An agreement to collaborate more closely in the field of cancer research was signed this year between KI and the MD Anderson Cancer Center at the University of Texas in the Unites States. Joint collaborative grants have been advertised over the course of the year within the scope of this collaboration. An academic symposium was arranged to coincide with the signing of the agreement involving speakers from both KI and the MD Anderson Cancer Center.

The Rockefeller University KI has worked together with the Rockefeller University in the United States through post-doctoral researcher exchanges, short-term exchanges for technical and academic staff and the series of Nicholson Lectures. These lectures are held alternately at the two universities. In 2013, KI renewed its collaborative agreement with the Rockefeller University for an additional three years up to 2016.

The Mayo Clinic The collaboration between KI and the Mayo Clinic in the United States continues, focussing on broader collaboration in research, education, administration and innovation. Joint grant funding for travel (40 applications; 19 awards) and projects (30 applications; eleven awards) has been awarded within the scope of this collaboration.

The University of Toronto KI’s collaboration with the University of Toronto has been stepped up in 2013. A post-doctoral programme for top-level medical research has been introduced. This has been brought about thanks to a donation from retired professional ice hockey player Mats Sundin and the University of Toronto. The first post-doctoral scholarships from the Mats Sundin Fellowship were announced in 2013.

RESEARCH

International joint publications 2011–2013

PALESTINA

0 1–10

11–50 51-200 201-1000

LESOTHO

1000+

Number of scientific articles published by Karolinska Institutet’s researchers in cooperation with one or more researchers from respective countries and/or territories. Certain data included herein are derived from the Web of Science ® prepared by THOMSON REUTERS ®, Inc. (Thomson®), Philadelphia, Pennsylvania, USA: © Copyright THOMSON REUTERS ® 2013. All rights reserved.

China KI collaborates with several universities in China and articles are jointly published together with over 50 universities and organisations. In 2013, VR, the Swedish Research Council Formas (Formas) and the Swedish Research Council for Health, Working Life and Welfare (Forte) have had two calls for proposals concerning research collaboration with China. Three research groups at KI were awarded grants. In autumn, a delegation from KI visited Shandong University. An academic symposium, an alumni reunion and a seminar for students were arranged to coincide with the visit. Researchers at Shandong University and KI have published many jointlyauthored articles.

The University of Minnesota KI collaborates with the University of Minnesota in the United States on post-doctoral exchanges and the symposium Frontiers in Biomedical Research. In 2013, a discussion began on expanding the scope of this collaboration, with resources being allocated to support advertising post-doctoral researcher posts in 2014 and 2015.

Equal opportunities The project Mento4Equality, which was funded by the Delegation for Gender Equality in Higher Education, came to an end in 2013. This project investigated opportunities for career progression in research from a gender equality and ethnicity perspective. The project has resulted in an increased understanding of the mechanisms and structures that contribute to inequality of opportunity at KI. The results will be presented in a discussion paper in English: Not the Chosen One – Gender, Ethnicity and Power in Research Careers. It will be possible to use the discussion paper in study programmes and by the senior management at various levels of the university to increase awareness of and knowledge about these issues. The Vice-Chancellor’s equal opportunities council is responsible for taking action on the discussion paper and the measures proposed as a result of the project. A couple of the proposals have been implemented during 2013 in KI’s equal opportunities action plan. At the end of the year, KI decided on a programme for special activity support for the departments that have for a period of time been recruiting female professors and visiting professors. To summarise, SEK 500,000 in special activity support is awarded per year over five years to departments when they employ a professor and SEK 350,000 per year for three years when they employ a guest professor. Further equal opportunities initiatives that affect research are described in the section Provision of Expertise and Equal Opportunities.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

KI IN SOCIETY – COLLABORATION AND INNOVATION

This year’s Nicholson lecture. Professor David Allis from Rockefeller University in consultation with professor Per Svenningsson, the academic coordinator for KI collaboration with Rockefeller University. Allis was appointed to hold this year’s Nicholson lecture at KI. The lecture is part of a collaboration programme between the two universities. Allis has discovered how a system that controls genes works, and his research has meant that epigenetics has exploded as an ANNUAL area of research. KAROLINSKA INSTITUTET REPORT 2013

Photo: Ulf Sirborn

KI IN SOCIETY – COLLABORATION AND INNOVATION

KI IN SOCIETY – COLLABORATION AND INNOVATION Karolinska Institutet (KI) collaborates extensively with other educational institutions, hospitals, government agencies, companies and organisations throughout the world. This collaboration is necessary if KI is to be a successful university. KI is the largest collaborative academic partner in Sweden for researchers in other countries. KI’s single largest partner, Stockholm County Council (SCC), facilitates vitally important clinical research and education. Over half of KI’s activities are conducted in the clinical environment, primarily in hospitals, but also in primary care and elderly care facilities. The areas around KI’s campuses in Solna and Huddinge are constantly being developed as strong nodes for life sciences research. KI shares its location with facilities including Karolinska University Hospital, Karolinska Institutet Science Park, Science for Life Laboratory (SciLifeLab), the Swedish Institute for Communicable Disease Control (the Public Health Agency of Sweden from January 1st 2014) and the European Centre for Disease Prevention and Control (ECDC). Royal Institute of Technology (KTH Royal Institute of Technology), Stockholm University and Södertörn University are the universities that are located closest in Stockholm with which KI collaborates. There is also close collaboration with organisations including Stockholm Science City, Flemingsberg Science, Uppsala University and several companies.

KAROLINSKA INSTITUTET

Management level

The Research Strategy Committee

Collaboration with SCC The objective of the collaboration between KI and SCC is to improve healthcare through research and education. Extensive restructuring of healthcare in the Stockholm region requires intensified collaboration between KI and SCC, and this takes place at various organisational levels.

Collaborative organisational structure The collaborative organisation KI/SCC allocates resources for research, development and education (RDE). This includes the ALF direct government funding (remuneration to SCC for medical education and clinical research) and the RDE funds the SCC allocates to the collaboration. There is also a reconciliation of the direct government funding for education and research that are allocated to KI. The leadership structure consists of the KI/SCC Management Group and three collaborative organisations for research, education and infrastructure. Collaborative activities are organised in RDE groups made up of the parties involved. The budget is drawn up primarily by the Research Strategy Committee, the Board of Higher Education and the Infrastructure Advisory Committee in advance of the KI/SCC Management Group’s joint proposal for an RDE budget that takes into account the SCC managed funds for medical education and research/RDE.

STOCKHOLM COUNTY COUNCIL

Management group KI/SCC

Board of Higher Education

The Infrastructure Commitee

Operational level

R & D group/community

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

KI IN SOCIETY – COLLABORATION AND INNOVATION

Project funding Calls for funding proposals take place annually for various activities including clinically-oriented medical research and development projects (ALF project funding) and funds for clinical posts at various levels such as clinical post-doctoral researchers and clinical researchers. A follow-up of these posts was undertaken in 2013. This showed that the researchers currently employed account for an extensive academic output. Collaboration involving national and international networks has been initiated and established. The researchers have competitively obtained large research grants from external sources of funding and their academic careers have progressed. Another current initiative is the establishment of translational, thematic centres in which the collective expertise of the researchers involved has to encompass both clinical and preclinical activities.

Integration of education, research and care A large proportion of the professional education at KI takes place in the form of clinical education/work integrated learning (WIL). Changes to the organisation of healthcare will place huge demands on this collaboration. The quality of the education offered to our students within the healthcare system must be assured and improved. The number of places must also increase. Several projects to improve WIL are being run together with SCC. In 2013, a decision was made to establish an additional four academic primary care centres (APCC) that will open in 2014. APCCs make an important contribution to uniting research, education, development, interprofessional learning and care. KI has worked actively to meet the increased demand for places on the clinical education and admissions wards, which are important venues for interprofessional learning. The decision has been made to start new clinical education and admissions wards. More information about placements is available in the section Bachelor’s and Master’s Education. In December 2013, the KI/SCC Management Group decided to establish a joint regional biobank. This field has been allocated additional SEK 20 million for 2014. The issue of whether to establish a laboratory for integrative informatics was also investigated in 2013. Such a laboratory will be set up in 2014.

and teachers, aside from their normal roles, are also involved in public debate as the authors of opinion pieces and books, as lecturers and by participating in fairs and conferences. Together with the association Public and Science, KI participated in several events in 2013 that aim to spread knowledge to a wider audience at, for example, Göteborg Book Fair, Researchers’ Night, which attracted 5,000 visitors, and at the Almedalen Week in Visby. Researchers from KI took part in several talks and debates during Almedalen Week.

Innovation support and collaboration with industry A significant proportion of the research that takes place at KI does so in close collaboration with companies, both Swedish and foreign. This allows for extensive exchanges of knowledge and also provides a source of funding. Over the course of 2013, KI received SEK 268 million in funding from companies, of which SEK 85 million came from companies based abroad. Beginning in 2013, SciLifeLab will act as a national resource for molecular life sciences. This is run jointly by KI, KTH Royal Institute of Technology Royal Institute of Technology, Uppsala University and Stockholm University and is funded by direct government funding and funds from the Knut and Alice Wallenberg Foundation and AstraZeneca. The establishment of a new centre for translational research in collaboration with AstraZeneca was decided in 2013. The aim is to conduct preclinical and clinical studies relating to cardiovascular diseases, metabolic disturbances and regenerative medicine. More information about research collaborations is in the section Research.

KI Holding AB Karolinska Institutet Holding AB (KIHAB) owns, sells and manages holdings in project and service companies. The aim is to commercially exploit projects and knowledge from KI in order to find practical applications for research findsings and know-how. KIHAB owns four active subsidiaries: Karolinska Institutet Innovations AB, Karolinska Institutet Science Park AB, Karolinska Institutet University Press AB and Karolinska Institutet Housing AB. There is more information about KIHAB in the notes.

Informing the general public KI works purposefully to inform the public sector, industry and the general public about the knowledge being created at the university. Research findings gain a wider audience through the use of the media, for example. In 2013, KI was mentioned an average of 42 times per day in the Swedish news media, a total of 15,291 times. KI was mentioned 15,172 times in the international media (source: Retriever). KI has been publishing KI Medicinsk vetenskap since 1994; a quarterly popular science magazine with a circulation of 23,500. This year, KI has also published a compiled English edition. Many of KI’s researchers

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

KI IN SOCIETY – COLLABORATION AND INNOVATION

Innovators Companies, researchers or students that wish to collaborate or develop innovative ideas, whether they can be commercialised or otherwise, are offered the support within KI’s innovation system. The vision is to make scientific knowledge in the field of medicine and health into something useful by improving translational ability and helping to increase the professional interaction between academic research and education and industrial companies.

Education and research in innovation and entrepreneurship KI conducts research and education in entrepreneurship through the Unit for Bioentrepreneurship (UBE), offering courses and a two-year international master’s programme. KI’s students are given the opportunity to undertake interdisciplinary studies through UBE’s collaboration with the Stockholm School of Economics, KTH Royal Institute of Technology, University College of Arts, Craft and Design and Stockholm University as part of the Stockholm School of Entrepreneurship. In 2013, 40 collaborative projects with companies and other organisations have been conducted in which students have been trained to shed light on and solve tangible problems. Ninety external teachers, supervisors and lecturers have been engaged throughout the year. The Swedish Government’s strategy for entrepreneurship in education states that entrepreneurship must be a common theme throughout. As one element of this strategy, the government has commissioned the Swedish Agency for Economic and Regional Growth to support the implementation of entrepreneurship in courses and study programmes at the Bachelor’s and Master’s levels, which has resulted in action plans for eleven study programmes at KI.

Advisory and industrial collaboration services KI’s Innovation Office, which was established in 2010 to comply with the government’s bill 2008/09:50, focusses on providing advice at an early stage, inspirational and informative activities and industrial collaboration. Researchers and students are of-

fered support and companies looking for academic partners can also get help from the Innovation Office. Over the course of 2013, 115 advisory cases was dealt with by the Innovation Office, 83 of which involved early-stage advice (72 researchers, 11 students). Of these cases, 47 have been followed by patent investigations or another type of coaching. Five of them have been passed on to KI Innovations AB in order to obtain Verification for Growth funding from Vinnova. An additional 32 cases relating to industrial collaboration on established research at KI have been dealt with in 2013. The Innovation Office collaborates with Uppsala University on matters such as advice on intangible rights, the project Bio-X (industrial collaboration) and support for collaboration, primarily for small businesses and SciLifeLab. Collaborative models are also developed together with the University of Gothenburg and Lund University. Collaboration on projects is conducted locally with KTH Royal Institute of Technology (the Knowledge Pilot: collaboration with regional SMEs), Södertörn University (EntréQ: entrepreneurship for female students) and is supported by regional structural funds, for example. Since it was established in November 2010, the Innovation Office has continually taken part in and organised events such as fairs, seminars and visits to institutions, the aim of which is to stimulate interest in innovation, raise the level of knowledge and increase the flow of ideas.

KI’s commercial projects incubator Karolinska Institutet Innovations AB is KI’s incubator, offering commercial advice and project management. This is where ideas and inventions based on research, primarily from researchers at KI, are evaluated. Aggregated with KI’s Innovation Office, KI Innovations AB has reviewed a total of 123 ideas and inventions in 2013. KI Innovations AB is responsible for allocating funding from Vinnova to evaluate the commercial potential of promising research findings. At the end of 2013, there were 30 active commercial projects, several of which were not part-owned by KI Innovations AB. Over 1,400 ideas and inventions have been evaluated since the company was founded in 1996.

Unit for Bioentrepreneurship

The Innovation Office

Karolinska Institutet Innovations AB

Karolinska Institutet Science Park AB

Karolinska Development AB

Research and education in entrepreneurship.

Support for private sector collaboration, information and guidance in innovation issues.

Incubator. Support for commercialisations and corporatisations. Licensing. Mature companies are sold to market participants, inluding Karolinska Development.

Provides premises, installations and Facility Management for life science companies.

Investment firm with a company portfolio, several originating from KI Innovations AB

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

KI IN SOCIETY – COLLABORATION AND INNOVATION

KI’s science park KI has a science park, Karolinska Institutet Science Park AB, which has tions in both Solna and Flemingsberg/Huddinge. There were 70 companies in the park in December 2013, employing 575 people. KI Science Park offers businesses both soft and hard infrastructure, meeting spaces for knowledge transfer and exchange of expertise, including through regular seminars and life sciences-specific support functions and services. KI Science Park also runs a service incubator in Flemingsberg, together with Södertörn University. The programmes ”From Business Concept to Business” and ”The Entrepreneur Programme” provide help with business development to people from KI, SCC and Södertörn University who have ideas. The programmes are supported by the project EntréQ. A new national node for life sciences companies is currently being established together with Medeon and Sahlgrenska Science Park, with support from Vinnova.

Karolinska Development AB (publ) – an independent investment company Karolinska Development’s objective is to create value for patients, researchers, investors and society by developing innovations from world-leading researchers into products that can be sold or licensed at a high rate of return. The portfolio – comprising 35 projects on 31 December 2012, 16 of which are in clinical development – is strong in the fields of cancer and other areas of significant medical need. Since April 2011, Karolinska Development B shares have been quoted on NASDAQ OMX Stockholm.

Selected key indicators for collaboration 2010–2013 2010

2011

2012

2013

2,824 265 69

2,792 250 79

2,935 241 73

3,049 268 85

425 133

422 129

395 124

291 131

51 17

69 17

63 14

56 8

178

235

250

241

52 38

57 42

64 45

80 60

F. Doctoral students employed in the private sector and public organisations (annual working units)

431

446

455

479

G. EU projects (FP6, FP7 och EU health programme) – as coordinator

204 29

222 31

234 21

229 19

H. Ideas advice cases treated at KI Innovations AB and the Innovation Office

157

178

123

I. KI Innovations AB active projects at turn of year

J. Companies within KI Science Park

K. Employed by companies within KI Science Park*

585

580

420

575

L. Scientific articles, percentage co-published with parties outside of KI (%)

M. Scientific articles, percentage co-published with parties outside of Sweden (%)

A. Externally financed research, total (SEK million) – from companies, total (SEK million) – from overseas companies (SEK million) B. Contract research (SEK million) – from companies, total (SEK million)) C. Contract education, total revenue (SEK million) – from companies, total (SEK million) D. Contract education (FTE students) E. Adjunct Professors (headcount) – of which are financed by Stockholm County Council

Sources: A–C: The financial system Agresso, D: The student database Ladok E: KI Recruitment Unit, F: The student database Ladok, G: Grants Office, H–K: Data from respective operations, L, M: Web of Science/KI University Library. Notes: F: New calculation method in accordance with ”LW10 Follow-up of Doctoral Students”. Updates apply to every year. G: Relates to ongoing projects. Decided on, but not yet started are not included. In 2013, there were no active FP6 projects. The figures referring to KI as coordinator do not include projects supported by the European Research Council (ERC). H: Refers to the net amount, 36 of which are funded by Vinnova’s programme Verification for Growth. This has had an impact on the number of active projects (I) which means that the figure is not directly comparable with the figures for previous years. Advice for early phase ideas, established at the Innovation Office from 2011. Data for 2009 and 2010 relates only to KI Innovations AB. K: Data on the number of employees is collected by survey. L, M. Preliminary data for 2013.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

COMMON TO THE ENTIRE ORGANISATION

Open house. In August 2013, Karolinska Institutet’s new Aula Medica building was completed and in September an open house event was held for employees and students at KI. More than 1,000 people took the opportunity to look over the new premises.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Photo: Erik Cronberg

––––

COMMON TO THE ENTIRE ORGANISATION

HUMAN RESOURCES AND COMPETENCE SUPPLY work integrated learning. This year, the university has decided to appoint a vice-dean for recruitment, with specific responsibility for the recruitment of teachers and researchers. The development of a plan to ensure the provision of teaching expertise continues.

Attracting, recruiting and keeping competent staff Karolinska Institutet’s (KI) objective for the provision of expertise and continuing professional development is to have qualified expertise in not only research and education, but also support functions. The overall objective is to carry out high quality education and research in both the short and long-term. Professional leadership and collegiality is vital to the university’s ability to fulfil its mission. KI offers a wide range of courses and initiatives for both groups and individuals to support the roles of managers and employees. All these measures aim to facilitate the fulfilment of the university’s objectives. Assessment and analysis of the fulfilment of objectives takes place in accordance with internal guidelines. The departments have a duty to analyse and take steps to ensure they have sufficient expertise. In 2013, work to implement systemic support for the provision of expertise has been started. This can function as operative and strategic support for planning the provision of expertise and also for planning continuing professional development initiatives. The university’s overall risk assessment identified a risk relating to insufficiency in the availability of teachers. Being able to recruit and hold onto teachers who are responsible for both research and education is key, as is the availability teachers for

Human resources report In October 2013, KI had 4,778 employees, equivalent to 4,283 full-time equivalent (FTE) employees. This is an increase of two per cent (91 FTE employees) on the same period in 2012. The increase is mainly composed of researchers and administrative staff. The number of doctoral students employed has also increased. Groups that have decreased in size include senior clinical lecturers and research assistants. Aside from employees, a large number of people who are not formally employed are involved in the work at KI, for example, visiting researchers, those on scholarships and unpaid readers. In addition, staff employed by the county council such as doctors, nurses and physiotherapists also conduct education or research at KI. The number of doctoral students (research students) employed amounted to 595 FTE employees in 2013 (572). There were 375 FTE doctoral students with educational grants, 71 of whom combined their doctoral studies with an assistant post, which is a slight increase on the previous year.

FTE employees, various categories of staff 2010–2013 2010

2011

2012

Change 2012–2013 (%)

2013

Number

Women (%)

Number

Women (%)

Number

Women (%)

Number

Women (%)

Professor, pre-clinical

190

203

214

222

Professor, clinical

142

144

153

151

-1

Senior lecturer, preclinical

112

134

122

109

-11

Research associate

Senior lecturer, clinical

138

165

161

149

-7

Lecturer

180

166

159

155

-3

Researchers

708

741

793

838

Doctoral students

519

544

572

595

896

971

913

960

Technical staff

Administrative staff

1,020

1,003

1,068

1,063

Total

3,944

4,109

4,192

4,283

Note: The figures above include all employees, regardless of the extent or length of their employment, but exclude those in assistant posts in combination with educational grants and adjunct teachers. Nor does it include employees on leaves of absence, parental leave, sick leave, early retirement etc. With regard to the number of employees, only those on full-time leaves of absence (rather than parental and sick leave) have been omitted. The figures for all employees (FTE and total) refer to October 2013. The calculation of FTEs, however, does not include staff on sick or parental leave, in accordance with Statistics Sweden’s instructions.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

COMMON TO THE ENTIRE ORGANISATION

employments extended. In October 2013, employed adjunct professors were equivalent to 18 FTE employees. Employed adjunct senior lecturers amounted to eleven FTE employees. The number of employed adjunct senior lecturers amounted to 14 (seven men and seven women).

There are also research students who support themselves by other means such as scholarships, a different post at the university or a clinical post. Over the course of 2013, a total of 345 people have been given permanent employment and 249 have left their posts. The turnover of permanent employees was approximately 11 per cent, which is a reduction compared with 2012 (14 per cent). Even when those with temporary posts and doctoral studentships are included, the total staff turnover has decreased somewhat on that of the previous year. This was about 21 per cent in 2013, a reduction of 2 percentage points.

Staff gender distribution About two thirds of KI staff are women. The gender distribution in the various staff categories is largely unchanged on that of 2012. Twenty-eight per cent of professors are women, which is a marginal increase. In the groups senior lecturers, research assistants and researchers, the gender distribution remains between 40 and 60 per cent. When it comes to the groups lecturers, doctoral students (employed), technical and administrative staff, women continue to constitute the overwhelming majority.

Newly-employed teachers Teaching positions must be advertised and appointed competitively. Exceptions may be made for those who are nominated for a position as professors or for appointments as adjunct teachers or visiting teachers. Twenty-one new professors (16 men and five women) have been appointed in the past year following advertisement of the post and the assessment of their expertise (see footnote below). An additional twelve new senior lecturers have been employed (all women). Three visiting professors have been employed (all men). In 2013, one woman and one man were promoted to professors. These two applied for promotion as permanently employed senior lecturers (and lecturers) had the right to win promotion if they fulfilled the eligibility requirements for the higher position. The right to promotion was removed from the Higher Education Ordinance as of 1 January 2011, and the university chose not to reinstate this in its Appointment Procedure. This year, 30 people have been employed as adjunct professors (22 men and eight women). A proportion of these were already employed as adjunct professors, but have had their

Gender distribution in various staff categories (total: 4,283) 103 89

Senior Lecturer = 150

Postdoctoral fellow = 149

114

Lecturer = 155

Senior research fellow = 838

441

Doctoral student = 595

215

380

353

709 782

800

Professor = 373

270

Administrative staff = 960

178

600

400

200

Technical staff = 1062

200

400

Women (total 2,697)

600

800

Men (total 1,586)

Newly appointed professors and lecturers, including forwarded, 2010-2013 2010

2011

Number

Women (%)

Advertised post 1

Promotion

Visiting Total

2012

2013

Number

Women (%)

Number

Women (%)

Number

Women (%)

100

Professor

Senior lecturer Advertised post

Promotion

Total

100

Of whom one man was nominated in 2012 and one in 2013.

42â&#x20AC;&#x2021;

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

COMMON TO THE ENTIRE ORGANISATION

Doctorate The number and proportion of teachers with doctorates continues to increase. This group includes professors, senior lecturers, research assistants and lecturers. Only the group lecturers contains teachers without doctorates.

20 per cent. In addition, a number of managers and leaders have undergone working environment training focussed on both the physical and psychosocial environment. Aside from online courses, programmes have also been conducted in collaboration with other universities in the Stockholm region.

Visiting Researcher Services

Number of teachers with doctorates and proportion of all teachers 2010–2012 (FTE employees) Year

Number of doctorates

Proportion of total (%)

2010

665

2011

707

2012

714

2013

717

Absence due to illness Absence due to illness was at roughly the same level in 2013 as in the previous year. However, one change is that the proportion of long-term absences has increased compared with 2012. This is the figure for one individual year and it is too early to express an opinion on any underlying causes. In general, KI has a low level of absence due to illness, but the statistics can be somewhat unreliable as staff conducting research and teaching do not have regulated working hours to the same extent as other members of staff.

Practical information and advice for researchers and doctoral students arriving or travelling abroad on exchanges is offered through Visiting Researcher Services. Since 2013, KI is the official contact point in the network EURAXESS services. This is a European network under the auspices of the European Commission and consists of 200 information centres in 40 countries. These centres provide researchers with information about such matters as residence permits, insurance, taxes, pensions and employment for accompanying relatives.

Working environment and health

2010

2011

2012

2013

2.0

1.9

1.8

57.0

48.9

32.1

35.1

Women

2.7

2.4

2.5

Men

0.9

1.0

0.8

In autumn 2013, KI drew up new working environment and health guidelines. These guidelines express the employer’s intentions and commitments and will support the implementation of KI’s overall task of contributing to the improvement of human health through research and education. Efforts to improve health and the working environment will be comprehensive, taking into account both the physical and the psychosocial factors. Over the course of the year, health promotion workshops, study programmes and courses in the fields of stress and sleep have been offered continually, as has scheduled training combined with individualised support. All employees have been offered a health promotion reimbursement of SEK 1,500. In addition, a specific initiative for animal technicians in the Department of Comparative Medicine has been implemented in 2013. Stress management groups that use the evidence-based ACT (acceptance and commitment therapy) model are a new initiative that started in 2013.

Employees >29 years of age

1.5

1.2

1.1

Salary structure

Employees 30–49 years of age

1.5

1.6

1.8

Employees >50 years of age

2.9

2.7

2.3

2.2

Absence due to illness 2010–2013, % Total Proportion of longterm absences

Long-term absence due to illness refers to a continuous absence of sixty days or more. Absence due to illness for women and men is stated as a percentage of the total regular working hours of the group. The figures thus do not indicate absence due to illness for women and men as a percentage of the total absence due to illness. Absence due to illness in age groups is calculated in a similar way.

Managerial and leadership development A basic range of leadership development programmes has been implemented over the course of the year, among them the Swedish National Defence College’s concept ”Developmental Leadership” and team-building for managers and leaders. The proportion of managers and leaders who took part in some form of leadership development programme in 2013 was about

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

The salary review of 1 October 2013 was concluded in December. The result was an average increase of 2.4 per cent. Individual salary discussions have been conducted on a trial basis with 232 employees from three departments and two sections in the university administration. The aim is for salaries to incentivise employees through clear wage differentiation and communication. An evaluation of the trial has been carried out. The results indicate that about 99 per cent of the discussions ended in agreement.

Equal opportunities KI’s equal opportunities efforts are based on the Discrimination Act. The Board and the Vice-Chancellor are ultimately responsible for these efforts being goal oriented. The Council for Equal Opportunities, reporting directly to the Vice-Chancellor, works strategically on the overall plan and also supports the work of, among others, departments and study programmes.

Photo: Erik Cronberg

COMMON TO THE ENTIRE ORGANISATION

New professors. This year’s ceremonial installation of professors was held in the Erling Persson auditorium in Aula Medica. In total 41 professors were installed, of which 11 were women. Closest to the camera are Cecilia Magnusson, adjunct professor of public health epidemiology, Sven-Erik Sonesson, adjunct professor of paediatric cardiology and Anders Thorell, adjunct professor of surgery. At the beginning of 2013, the Council for Equal Opportunities drew up a three-year plan for employees and students with ongoing measures and specific initiatives that run up to and including 2015. The plan encompasses all of the grounds for discrimination listed in the Discrimination Act and was ratified by the Vice-Chancellor in March 2013. Additional reporting of equal opportunities matters is included in the section for the respective operational area.

Working environment and disability – or the complex capacity for work The aim of this working environment initiative, specifically focussed on disability, is to combat unemployment and exclusion through surveying needs and proposing workplace adaptations. In 2013 a pilot project was implemented that took the form of an interview study in collaboration with the Department of Neurobiology, Care Sciences and Society – Division of Occupational Therapy. The study shows that the support provided to employees who return to work following a long period of absence due to illness work well. However, people with fatigue syndrome, mental illness and complex conditions may need further support. The report was presented at two meetings with human resources managers and other concerned parties in December 2013.

Even gender distribution in planning and decision-making bodies and managerial posts In January 2013, the gender distribution in academic managerial posts such as Vice-Chancellor, Pro-Vice-Chancellor, deans and vice deans was uneven.

One of the measures taken to give KI’s planning, advisory and decision-making bodies an even gender distribution in future was the implementation of an interview study. This targeted women who were involved in the initial stages of the recruitment process, but who were not selected as candidates. Among the factors analysed were the clarity of the criteria for the appointments process and the grounds the nominees not being selected as candidates.

Recruitment targets for female professors In the public service agreement for financial year 2012, the Swedish Government stipulated a recruitment target that at least 47 per cent of the professors employed by KI between 2012 and 2015 must be women. This target includes newlyemployed and promoted professors and visiting professors, but not adjunct professors. The proportion of women in the group employed, promoted and visiting professors amounted to 26 per cent in 2012 and 2013. In 2013, an action plan containing specific initiatives has been drawn up. The action plan includes measures such as support to departments that employ female professors, following advertising the post or promotion, or visiting professors. The plan also involves quality assurance taking place of the recruitment process, continuing professional development initiatives and specific funding for female supervisors – part-funding of new doctoral students. More information in the section Research).

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

COMMON TO THE ENTIRE ORGANISATION

INFRASTRUCTURE The infrastructure plan initiated in 2007/2008 involved what amounts to two stages. The first stage ended in 2013, when a number of buildings were complete at the same time as certain core facilities had been improved. The second stage refers to the period up until 2018. Consequently, this is a matter of planning for a tenyear period. The five years ahead require additional improvements to the efficiency of our use of premises if there is to be space for growth. The new buildings have also resulted in an increase to the average rental cost and KI’s internal rental charges must be adapted to this. The cost of depreciation of the interior fixtures and fittings connected to the new buildings has also increased.

KI’s portfolio of premises and costs Year

Area sq.m. (MUA)

Cost ( SEK m.)

Percentage of total costs

2010

204,494

565

2011

200,859

586

2012

213,881

667

2013

218,870

741

Examples of infrastructure projects Karolinska Institutet Science Park (KISP) The final stage of Karolinska Institutet Science Park at the junction of Solnavägen and Tomtebovägen was completed in 2013. As planned, the three buildings contain a range of large and small companies, together with parts of KI’s innovation system and an advanced research establishment, SciLifeLab, which involves three other universities.

The WBerg Animal House Construction at KI’s animal houses, which began several years ago, was largely completed in 2013. The largest investment related to the new WBerg Animal House, which was officially opened in 2012, but only came into use to any great extent in 2013. KI now has animal houses of a high standard and of sufficient capacity for the years to come, until the future research laboratory Biomedicum is complete.

Student and visiting researcher accommodation The accommodation in Vårberg was ready for occupation in April 2013. About 400 new apartments are planned for Solna. It is planned that this accommodation will consist of four tower blocks containing small apartments. Detailed plans are expected to be approved in April 2014, and KI will then decide whether or not to complete the project.

Additional examples of planned projects In 2013, the detailed planning of KI’s new future laboratory for experimental research, Biomedicum, began. This is expected to be completed in 2018. KI has signed an initial contract for a feasibility study on the construction of a 15,000 m2 research building in Huddinge. If it is decided to proceed with construction, the building will be completed in 2017. The learning environment project, which is a collaboration between KI and SCC, is producing the learning environments of the future. By using a recurring concept, a coherent identity is created in the buildings affected. In 2014, additional formal and informal environments are planned for Solna and Huddinge.

A further two buildings, Aula Medica and the Widerström Building, were opened in 2013. The new buildings have meant that the supply of premises has been able to match demand temporarily, but the rate of vacancies is very low and there is no margin for any more growth. Aula Medica has been built thanks to a donation from the Erling Persson Family Foundation to coincide with KI’s 200th anniversary. The building contains an auditorium with 1,000 seats, offices, conference facilities and restaurants. In 2013, three departments moved into the Widerström Building, that contains offices and learning environments.

Informatics and biobanks The work on the two priority infrastructure areas, informatics and biobanks, has continued this year, with the goal of creating a coherent information chain in healthcare. The establishment, from the beginning of next year, of a joint KI and SCC biobank, was decided on in December 2013. SMB will act as an umbrella organisation for biobanks in the Stockholm region and the will make it possible to collect samples from both research and healthcare.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Photo: Erik Cronberg

Aula Medica and the Widerström Building

The turf-cutting ceremony. Sten Wetterblad, regional director of Akademiska Hus; Jan Björklund, Minister for Education; Pehr Granfalk (conservative party), chairman of the board of Solna Municipality; Chris Heister, governor of Stockholm, and Anders Hamsten, Vice-Chancellor of KI, together make the first cut of turf for the construction of the Biomedicum research laboratory.

COMMON TO THE ENTIRE ORGANISATION

Photo: Linda Lindell

SUSTAINABLE DEVELOPMENT

Course in sustainable development. Starting in the autumn term 2013, all postgraduate students who have a doctoral post that includes work in laboratories are to take a compulsory course on how environmentally harmful and hazardous substances must be handled.

Research and education for sustainable development A healthy population and environments that promote health are important prerequisites for sustainable societal development. Even though all research conducted at Karolinska Institutet (KI) aims to contribute to improving human health, research that highlights the connection between health, socioeconomic factors and the human impact on the environment is particularly important to long-term sustainable development. ”Our courses and study programmes will provide students with knowledge about how they can contribute to sustainable development in their future professional roles and as citizens.” This quote is taken from Karolinska Institutet’s Education Strategy 2013. In order to achieve this goal, we have taken steps to integrate sustainable development into our courses and study programmes to an greater extent. One example is that all doctoral students working in laboratories and were admitted from autumn term 2013 are obliged to attend a course (1.8 credits) on the safe handling of substances that are harmful to the environment and health. The course includes sustainable development in a separate course element. This is one tangible example of a course prioritised from a sustainability perspective. From a wider perspective, we have this year been involved in national and international collaboration with other universities in the ongoing effort to incorporate sustainable development into our education and research.

Sustainable campus In the past year, several environmentally-related projects and actions were implemented that contribute to providing a sustainable workplace. A selection are presented here. In 2013, KI has taken several steps towards a greener and more versatile IT system, for example, improved opportunities to take part in virtual meetings, reduced electricity use thanks to virtual servers, more environmentally friendly PCs and a monitoring system that facilitates the identification of inefficient IT equipment. Environmental requirements in public procurement and purchasing can have an environmental impact. KI’s procurement regulations were revised in 2012 to include a clear sustainability perspective. A new e-commerce system is under development. Its benefits will include making it easier to choose environmentally certified products. The university is also attempting to reduce its environmental impact by reducing energy use in its buildings. This is exemplified by two large projects that have been taking place this year, involving the reconstruction or modification of premises in both Huddinge and Solna to reduce energy consumption. The departments’ individual environmental activities are also significant. Department representatives met during a workshop where they got expert help and shared knowledge.

Environmental management system KI’s environmental and sustainable development management system is built to meet the requirements of the international environmental management standard ISO 14001. The university’s long-term work has been followed-up in an audit report. The challenges identified include following up the environmental requirements for purchasing/procurement and introducing a deviation management system. KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Photo: iStockphoto

FINANCIAL REPORT

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Direct government funding and donations. Karolinska Institutet’s turnover for 2013 was SEK 5,8 billion, which is an increase of 150 million, compared to 2012. KI’s revenue consists of 45 percent of state direct government funding and 55 percent of council funds, contributions and donations from foundations, organizations, companies and local governments. 47

FINANCIAL REPORT

FINANCIAL REPORT Karolinska Institutet (KI) had a turnover of SEK 5,796 million (SEK 5,646 million) in 2013, which is an increase of SEK 150 million or 2.7 per cent, compared to 2012. A positive change in capital of SEK 7.6 million (SEK 108 million), of which KI’s main business were accountable for SEK -1.2 million loss (SEK 139.5 million) and KI´s subsidiary Karolinska Institutet Holding AB earnings was preliminarily for SEK +8.8 million (SEK -31.5 million). Additional information under the heading Change in capital for the year. In this section, Agresso should be considered as the source unless otherwise stated.

Bacherlor’s and Master’s education Revenue The total increase in revenue for the year, SEK 37.4 million over last year’s figure, is due to an increase in the direct government funding of SEK 41.7 million (5.0 per cent). As KI has exceeded what is known as the funding cap in the settlement for full-time equivalent (FTE) students and annual performance equivalents (APE) in 2013, SEK 30.4 million in direct government funding savings from previous years have been returned. In total, KI has SEK 19.4 million in remaining direct government funding savings at the close of 2013 (further information in the direct government funding report and Note 1. KI received an additional SEK 7.3 million in appropriated funds in 2013, directed at the expansion of nursing programmes. The direct government funding has been adjusted for prices and salaries by 0.57 per cent (0.9 per cent). Activities within the scope of the ALF agreement are reported in the section KI in Society – Collaboration and Innovation. Revenue in the item fees and other remuneration decreased compared to 2012, which is due to factors such as the Swedish National Board for Health and Welfare’s investment in education within the field of psychiatry ended in 2012. Further information in Note 2. The item revenue from grants consists primarily of grants from other government agencies transferred to KI for educational activities.

Expenses Total expenses for the year decreased by SEK 15.1 million compared to 2012, and we see reduced expenses in all types of expenses, except for the item operating expenses, which increased by 4.3 per cent. The increase in operating expenses arises mainly in purchasing of services. Financial expenses consists of the item interest on overdue payments. Depreciation increased, which is mainly due to increased investments in interior fixtures and fittings and equipment connected to the new buildings that have come into use over the course of the year.

Total: Bachelor’s and Master’s education 2010–2013 (SEK millions) 2010

2011

2012

2013

Direct government funding

754.0

805.5

833.1

874.8

Fees and other remuneration

83.9

100.0

100.6

97.3

Grants

12.7

20.6

19.8

18.9

0.1

0.0

850.7

926.2

953.6

991.0

434.0

488.2

507.7

483.4

99.6

99.0

109.2

100.4

295.1

318.1

335.7

350.3

REVENUE

Financial income Total revenue COSTS Staff Premises Other operating costs Financial expenses

0.2

0.3

0.1

23.3

17.9

12.2

15.7

852.1

923.5

965.0

949.9

Government funding

4.3

7.3

7.6

Funding from other government agencies

0.0

Other funding

0.0

0.1

-4.3

-7.3

-7.6

-7.7

-1.4

2.6

-11.4

41.1

Balance brought forward

137.9

136.5

139.1

127.8

Total (balance carried forward)

136.5

139.1

127.8

168.8

Depreciation Total costs TRANSFERS

Grants paid CHANGE IN CAPITAL For the year

Research and doctoral education Revenue Research revenue for the year amounted to SEK 4,804.8 million (SEK 4,692.0 million). The direct government funding was increased by SEK 30.4 million, 1.8 per cent, compared to 2012. The increase is not as extensive compared to previous years because the Government’s increased investment in strategic research areas, SFO, has subsided as planned in 2013. The takeover of activities from the Swedish Institute for Communicable Disease Control is funded by a direct government funding from 2013; this funding was also in place in 2012 as external grants. The direct government funding has been adjusted for prices and salaries by 0.57 per cent (0.9 per cent).

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Activities within the scope of the ALF agreement are reported in the section KI in Society – Collaboration and Innovation. Fees and other remuneration decreased by SEK 57.9 million compared to the previous year. In 2012, the commission from Stockholm County Council concerning KI’s Public Health Academy came to an end, which had a corresponding reduction in the revenue for the year of SEK 68.7 million. Further information is contained in the table in Note 2. Revenue from grants increased by SEK 144.5 million or 6.5 per cent. The largest increase was due to increased grants from government agencies and councils, as well as Swedish non-governmental donors and foundations. Grants from the EU also increased (further information in the list of large individual funding sources in Table 8). Financial income decreased by SEK 4.2 million compared to 2012, due primarily to a lower rate of interest on the proceeds on the interest-bearing account at the Swedish National Debt Office. In 2013, the annual average interest rate on the interestbearing account was 1.01 per cent (1.47 per cent).

Expenses Total expense for the year was increased by SEK 306 million, 6.7 per cent, compared with 2012. Staff costs were increased by SEK 143.5 million, 6.1 per cent, compared with 2012. The number of FTE employees increased by 91 compared with the same period in 2012, with the largest increase seen in research activities. The result of the salary review on 1 October 2013 was an average increase of 2.4 per cent. At the end of the year, KI’s premises portfolio amounted to 218,870 m2 (213,881 m2), an increase of 2.3 per cent, the largest increase resulting from research activities. In addition to the indexed increase in rents, the expense increase is the result of expansion of operations and several new buildings coming into use (further information in the section Common to the Entire Organisation). Increased operating costs, 4.3 per cent,is the result of expanded operations. Financial expenses consist primarily of the items interest expenses at the Swedish National Debt Office and exchange rate losses. Despite an increase in borrowing for investments this year, interest expenses decreased due to lower interest rates on loans from the Swedish National Debt Office. The annual average interest rate in 2013 was 1.01 per cent (1.47 per cent). Depreciation increased, which is primarily due to increased investments in interior fixtures and fittings and equipment connected to the new buildings that have come into use over the course of the year.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Total: research and doctoral education (including asset management) 2010–2013 (SEK millions) 2010

2011

2012

2013

1,581.5

1,630.1

1,732.4

1,762.8

696.8

641.0

670.1

612.2

2,095.0

2,077.6

2,234.6

2,379.1

29.1

65.6

54.9

50.7

4,402.4

4,414.3

4,692.0

4,804.8

2,171.7

2,265.2

2,363.5

2,507.0

465.0

486.7

557.7

640.8

1,364.0

1,326.7

1,433.2

1,494.2

7.4

28.3

8.9

9.5

134.1

157.2

177.8

195.6

4,142.2

4,264.1

4,541.1

4,847.1

Government funding

6.1

13.2

12.2

13.4

Funding from other government agencies

20.9

29.6

34.7

42.2

Other funding

35.5

82.9

84.7

86.9

-62.5

-125.7

-131.6

-142.5

For the year

260.2

150.2

150.9

-42.3

Balance brought forward

552.9

813.1

954.3

1,105.2

Total (balance carried forward)

813.1

963.3

1,105.2

1,062.9

REVENUE Direct government funding Fees and other remuneration Grants Financial income Total revenue COSTS Staff Premises Other operating costs Financial expenses Depreciation Total costs TRANSFERS

Grants paid CHANGE IN CAPITAL

FINANCIAL REPORT

Funding KI’s revenue is categorised by sources of funding according to the diagram. The largest individual sources of external funding are listed in the Tables Appendix, Table 8.

Karolinska Institutet’s revenue for 2013, SEK 5,796 million in total (SEK 5,646 million) Research councils 14 % (13 %) Government funding 46 % (45 %) Other government agencies 7 % (7 %)

Swedish foundations and organisations 14 % (13 %)

Foreign foundations and organisations 6 % (6 %) Swedish companies4 % (4 %) Foreign sompanies 1% (1%) Financial revenue County councils 1 % (1 %) and municipalities 7 % (10 %)

Grant awarded to other organisations In 2013, KI awarded grants of SEK 1 million to the Verksamhetsstaden Foundation and SEK 500,000 to the Flemingsberg Science Foundation.

Change in capital for the year The net change in capital, SEK 7.6 million (SEK 108 million), is related to business education at the Bachelor’s and Master’s education plus SEK 41.1 million and research and doctoral education, with minus 42.3 million kronor. The positive change in capital for education depends largely on the lag in consumption of government subsidies for yet executed operations. As for the research so derived, the negative change in capital for the most part to activities that are funded by direct government funding. It can be concluded that the business is growing at a faster rate than before, resulting in faster consumption of both this year’s and previous years’ funds received. KI’s subsidiary, Karolinska Institutet Holding AB, showed a positive outcome of 8.8 million. This amount consists of the 2013 preliminary results and the adjusted fixed income for 2012.

Statement of financial performance by operational area 2013 (SEK millions) Total

Bachelor’s and Master’s education

Research and doctoral education

2,637.6

874.8

1,762.8

Revenue Direct government funding Fees and other remuneration Grants Financial income Total revenue

709.5

97.3

612.2

2,398.0

18.9

2,379.1

50.7

0.0

50.7

5,795.8

991.0

4,804.8

2,990.3

483.4

2,507.0

741.2

100.4

640.8

1,844.5

350.3

1,494.2

9.6

0.1

9.5

211.4

15.7

195.6

5,797.0

949.9

4,847.1

-1.2

41.1

-42.3

Costs Staff Premises Other operating costs Financial expenses Depreciation Total costs Change in capital for the year (excluding subsidiaries and general revenue) Profit/loss from holdings in subsidiaries and associated companies

8.8

Profit/loss from collection of general revenue

0.0

Change in capital for the year (including subsidiaries and general revenue)

7.6

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Outcome compared with forecast Statement of financial performance 2013 (SEK millions) Result

Forecast

Difference

Revenue Direct government funding

2,638

2,653

External funding, fees and grants

3,107

3,081

5,796

5,780

2,990

3,005

741

700

1,845

1,830

Financial Total revenue

Costs Staff Premises Operating costs Financial

211

213

5,797

5,758

-1

-23

Depreciation Total costs Change in capital for the year

Comments on the differences between outcome and forecast

Net advances from external funding sources and liquid assets

The difference between the outcome and the forecast for the item direct government funding is due to an excessively low estimate in the interim report of the amount of previous years’ direct government funding savings for Bachelor’s and Master’s education that were returned, and because transfers of direct government funding to other universities were not taken into consideration. Further differences requiring comment are seen in the income item external funding, fees and grants. This item is difficult to estimate as it is uncertain, at the time of the forecast, how much of the external funding will be used to finance various activities. External funding is revenue only when they are consumed, as opposed to government appropriations, which are revenue in their entirety when received, regardless of their use. Expenses regarding premises are the main difference in the expense item category. Premises expenses were higher than anticipated due to the ongoing major infrastructure investments, which are difficult to forecast accurately.

Unexpended grants and deferred revenue from commissions relate to non-accrued expenses for activities where remuneration is reimbursed in advance by the funding source. Accrued grants and revenue consists of accrued expenses for ongoing externally funded activities, where remuneration is received afterwards and where agreements/contracts are available to confirm this. The table below shows how the development of advances from grants and commission-funded activities have changed over time. The table is reduced with ongoing work invoiced/ requisitioned retrospectively and liquid assets.

Agency capital Accumulated agency capital, including the net change in capital, amounted to SEK 1,296.2 million (1,288.6), divided in subsidiaries of SEK 64.3 million (SEK 55.5 million), asset management SEK 31.5 million (30.2 million) and ongoing activities SEK 1,200.4 million (SEK 1,202.9 million). Further information in Notes 11 and 25.

Net advances and liquid assets 2010–2013 (SEK millions) 2010

2011

2012

2013

2,224

2,277

2,313

2,445

362

358

294

260

-216

-205

-208

-256

-4

-9

-8

-10

Net advances

2,366

2,421

2,391

2,439

Liquid assets, bank and Swedish National Debt Office

3,064

3,384

3,388

3,290

Unexpended grants Deferred revenue from commissions Accrued grants Accrued revenue from commissions

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Asset management

Yield

Karolinska Institutet administers individual donations intended for medical science at KI. Donations are categorised into: 1. Funds reported within KI as an authority 2. Independent foundations that are their own legal entities For funds, which are managed and reported within KI, both the return and the capital may be used. The foundations are separate legal entities, and issue their own separate annual reports. The foundations distribute return to KI are reported as external grants in KI’s accounting. Summaries of KI’s foundations’ are reported in order to provide a complete picture of KI’s donated assets, regardless of their legal format.

The total yield of the portfolio was 9.8 per cent in 2013. The relative yield compared to the market index was -2.8 percentage points. This is due to factors including ethical restrictions and exposure to shares in growth markets.

Yield in per cent compared with the reference index 2010–2013 2010

2011

2012

2013

KI’s funds

1.9

-3.8

6.4

9.8

Reference index

4.1

0.9

6.9

12.6

Yield is stated net, i.e. including dividends and deductions for administrative costs. Share indices are stated inclusive of reinvested dividends.

Funds

Indices used for comparison in 2013

Growth of invested funds during 2013

Swedish fixed interest

OMRX Bond

30 %

MSCI World NDR (expressed in SEK)

40 %

Alternative investments

SSVX 12 M + 3 percentage points (year on year)

30 %

At the end of the year, the market value of the mutual funds and fixed income funds administered by KI amounted to SEK 270.7 million (SEK 259.0 million). In 2013, the net outflow (difference between purchases and sales of funds) was SEK -14.3 million (SEK -28.6 million) and the change in value SEK +25.7 million (SEK +16 million). The portfolio consists of 38.6 per cent (49.3 per cent) Swedish and foreign mutual funds and 33.4 per cent (41.1 per cent) Swedish fixed income assets. Alternative investments account for 28 per cent (9.6 per cent) of the portfolio.

Interest-bearing securities 26,9 %

Alternative investments 28 %

Dividends from KI’s funds In 2013, SEK 67.7 million in dividends has been allocated to organisations that are part of KI. This is distributed by purpose in accordance with the table below.

Payments from KI’s funds (SEK millions) Research grants

Cash 6,5 %

Swedish share funds 7,9 %

2010

2011

2012

2013

32.0

44.8

35.1

61.4

Travel grants

0.6

First-cycle education

0.9

1.1

0.1

0.4

Other

20.0

5.3

Total

53.5

66.5

55.8

67.7

Donations to KI Global share index funds 30,7 %

In 2013, KI has received a total of SEK 82.3 million (SEK 90.9 million) in external donations. Individual donations of SEK 2 million or more are reported below.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Amount (SEK millions)

Research purpose

Donor

Breast cancer research

Hans & Märit Rausing

20.0

Medical research and doctoral education

Tyra and Gustav Svensson Memorial Foundation

14.6

Professorship in clinical treatment

Meda AB

7.0

Jubilee professorship

Torsten Söderberg Foundation

7.0

Cognitive neuroscience

Jochnick Foundation

5.0

Mission: Fight Stroke

Swedish Heart-Lung Foundation

4.5

Support for young research assistants

Bertil Hållsten’s Research Foundation

4.0

Scientific research primarily concerning cancer

Sune and Charlotta Hay Foundation

3.3

Support for young, gifted researchers

William K. Bowes Jr Foundation

2.7

Haematology research

Dr Åke Olsson Foundation

2.5

Haematology research

Björn & Lena Ulvaeus

2.0

Cognitive neuroscience

Mattias & Sonia Westman

2.0

KI’s foundations There are 216 associated foundations that issue financial statements and annual reports. No new foundations were established in 2013. Nineteen foundations have been completed at the discretion of, either, the Swedish Legal, Financial and Administrative Services Agency or of KI’s Board of Research since the entire capital may be claimed in order to fulfil the foundation’s purpose. New donations totalling SEK 17.3 million have been invested in existing foundations. In comparison with 2013 net wealth has increased by 163 million, or 13.2 percent, after dividends included new donations. At the end of the year, the foundations’ assets consisted of Swedish shares 19 per cent (22), foreign shares 42 per cent (41), hedge funds 19 per cent (8), fixed income securities 19 per cent (27) and liquid assets 0.5 per cent (2). During the year, SEK 29 million has been awarded to KI from the foundations, SEK 2.2 million of which consisted of released restricted assets. The purpose and direction of the grant is determined by the aim of each foundation. For foundations under the management of KI, KI has received remuneration of SEK 1 million for administrative expenses.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Foundations 2010–2013 (SEK millions) Asset value Grants awarded*

2010

2011

2012

2013

1,244

1,166

1,235

1,398

47.5

45.1

35.8

29.6

*Amounts for 2010–2011 are adjusted with regard to research grants to KI from external foundations. They have previously been erroneously reported here.

FINANCIAL REPORT

Statement of financial performance (SEK in thousands) Outcome

Outcome

01/01/2013

01/01/2012

31/12/2013

31/12/2012

2,637,584

2,565,547

709,537

770,747

2,397,965

2,254,418

50,730

54,902

5,795,816

5,645,615

-2,990,305

-2,871,225

-741,187

-666,949

-1,844,491

-1,768,913

-9,649

-9,010

-211,369

-189,991

-5,797,001

-5,506,088

-1,184

139,527

8,825

-31,542

2,186

2,117

-2,219

-2,114

-34

Funding received from the Government budget for the financing of grants

20,984

19,801

Funding received from Government agencies for the financing of grants

42,191

34,745

Other funding received for the financing of grants

87,119

84,661

-150,294

-139,206

7,606

107,989

Operating revenue Revenue from direct government funding (Note 1) Revenue from fees and other remuneration (Note 2) Revenue from grants (Note 3) Financial income (Note 4) Total revenue

Operating expenses Staff costs (Note 5) Premises costs (Note 6) Other operating costs (Note 7) Financial expenses (Note 8) Depreciation and write-downs (Notes 12–14) Total costs

Operating profit/loss

Profit/loss from holdings in associated companies and subsidiary

Collection of general revenue(Note 9) Revenue from fees etc. and other revenue not at the authority’s disposal General revenue transferred to the Government budget Balance

Transfers (Note 10)

Grants distributed Balance

CHANGE IN CAPITAL FOR THE YEAR (Note 11)

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Balance sheet (SEK in thousands) ASSETS

31/12/2013

31/12/2012

Capitalised expenditure for development

5,199

3,828

Rights and other intangible fixed assets

3,528

2,972

8,727

6,800

34,327

42,631

827,873

662,921

44,472

65,272

906,672

770,824

64,282

55,458

226,139

236,251

290,421

291,709

Accounts receivable

136,419

145,359

Receivables from other Government agencies (Note 18)

114,948

95,014

874

303

252,241

240,676

Prepaid expenses (Note 20)

161,628

151,478

Accrued grant revenue (Note 21)

256,053

207,733

Other accrued revenue (Note 22)

19,226

10,512

436,907

369,724

-19,778

-50,130

-19,778

-50,130

3,182,339

3,244,073

107,530

143,503

3,289,868

3,387,576

5,165,058

5,017,179

Intangible fixed assets (Note 12)

Total intangible fixed assets Tangible fixed assets Expenditure for improvements to leased property (Note 13) Machinery, equipment, fixtures and fittings etc. (Note 14) Fixed assets under construction (Note 15) Total tangible fixed assets Financial fixed assets Holdings in associated companies and subsidiary (Note 16) Other long-term securities holdings (Note 17) Total financial fixed assets Receivables

Other receivables (Note 19) Total receivables Cut-off items

Total cut-off items Settlement with the Government Settlement with the Government (Note 23) Total settlement with the Government Cash and bank balances Balance of the interest-bearing account at the Swedish National Debt Office (Note 24) Cash, plusgiro and bank balances Total cash and bank balances

TOTAL ASSETS

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

55â&#x20AC;&#x2021;

FINANCIAL REPORT

Balance sheet (SEK in thousands) CAPITAL AND LIABILITIES

31/12/2013

31/12/2012

5,238

50,458

82,000

1,232,865

1,093,334

7,606

107,989

1,296,167

1,288,561

Provisions for pensions and similar obligations (Note 26)

10,299

7,438

Other provisions (Note 27)

31,083

39,776

41,382

47,214

Loans at the Swedish National Debt Office (Note 28)

541,210

442,336

Liabilities to other Government agencies

113,275

105,610

Accounts payable

187,728

247,332

Other liabilities

119,147

137,349

Total liabilities etc.

961,360

932,627

141, 059

133,031

2,444,749

2,313,002

280,341

302,743

2,866,149

2,748,777

5,165,058

5,017,179

40,644

183,900

Agency capital (notes 11+25) Government capital Shares of earnings in associated companies and subsidiary Change in capital brought forward Change in capital according to the statement of financial performance Total agency capital

Provisions

Total provisions

Liabilities etc.

Cut-off items Accrued expenses (Note 29) Unexpended grants (Note 30) Other prepaid revenue (Note 31) Total cut-off items

TOTAL CAPITAL AND LIABILITIES Contingent liabilities (Note 32)

56â&#x20AC;&#x2021;

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Accounting Principles

This annual report has been prepared in accordance with the Swedish Annual Reports and Budget Documentation Ordinance (2000:605). Karolinska Institutet follows generally accepted accounting principles, in accordance with the Swedish National Financial Management Authority’s general advice on Section 6 of the Swedish Book-keeping Ordinance (2000:606). Revenue and costs are allocated to a particular period in accordance with the accruals concept. The cut-off amount is SEK 20,000. The limit for a write-off against equity is set at SEK 20,000.

Valuation of receivables and liabilities

Receivables have been entered at the amount which, after individual examination, is expected to be paid. In those cases where invoices or equivalent have been received after the set cut-off date (03/01/2014) or where the amount of the receivable or liability was not known exactly when the accounts were produced, these amounts are reported as cut-off items. Foreign currency receivables and liabilities have been valued at the exchange rate on the balance sheet date.

Valuation of bank balances in foreign currencies

Foreign currency bank account balances have been valued at the exchange rate on the balance sheet date.

Donations

The acquisition value of a donation is valued at its market value on the acquisition date. In the case of bequeathed gifts, the acquisition date is considered to be the date the estate is settled.

Valuation of intangible fixed assets

Intangible fixed assets are assets developed by KI which are intended to increase KI’s administrative service potential. Their financial lifetime shall be at least three years and their acquisition value shall be at least SEK 20,000. The acquisition value includes both external purchases and KI’s own direct costs. Facilities are depreciated linearly at a maximum of five years from the month of acquisition.

Valuation of tangible fixed assets

Assets, excluding computers, intended for permanent use with an acquisition value of at least SEK 20,000 and have an estimated financial lifetime of three years or longer are defined as fixed assets. Computers with an acquisition value of up to SEK 30,000 are reported as costs immediately if their estimated financial lifetime is less than three years. Objects, which together constitute a functional unit, with a combined acquisition value of SEK 20,000 or more are classified

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

as fixed assets. These assets are reported at their acquisition value less accumulated depreciation according to plan. Fixed assets are depreciated linearly over their assessed financial lifetime. The depreciation periods for machinery, equipment, fixtures and fittings etc. are applied according to an estimated life of three, five or ten years.

Financial fixed assets

Bonds: On purchase, the purchase price is entered in the balance sheet as a financial asset. On selling, the financial assets are reduced by the book value and any difference is entered in the statement of financial performance as a capital gain or capital loss. Shares/participations: On purchase, the purchase price is entered in the balance sheet as a financial asset. On selling, the financial assets are reduced by the book value and the difference is entered in the statement of financial performance as a capital gain or capital loss. Depreciation and appreciation: If the total market value of the portfolio is considerably less than the book value and it is not certain whether this decrease is permanent, a depreciation is performed. Depreciation is entered by reducing financial assets in the balance sheet against en increase in financial expenses in the statement of financial performance. Depreciations and appreciations are reversed by decreasing or increasing financial expenses when the market value rises.

Externally financed operations

When allocating grants or fees to a particular period, the revenue for the period is determined by the costs for the period. Residual revenue from grants or fees is allocated to a particular period as unexpended grants/fees or other prepaid revenue. Unexpended revenue that is not grants or fees is taken up as income against the change in capital for the year. For projects where payment is received afterwards and where this is confirmed by an agreement/contract, the costs are allocated to a particular period against other accrued revenue (in the case of fee financing) or as accrued grantrevenue (in the case of grant financing). If there is no agreement/contract, the costs are taken up as income and affect the change in capital for the year.

KI Holding AB

On 1 January 1998, Karolinska Institutet took over the administration of Karolinska Institutet Holding AB from the Ministry of Industry and Commerce. In the annual report, details of participations in subsidiaries are reported as share in earnings according to the equity method. The holding is reported in the balance sheet under the items Holdings in associated companies and subsidiary, Government capital and Shares in earnings in associated companies and subsidiary.

FINANCIAL REPORT

Expenditure for improvements to leased property

Improvements to leased property are treated as a direct cost when they amount to a maximum of SEK 500,000. Investments totalling a higher amount will be dealt with via rent surcharges.

Reporting of combined positions

In 2012, KI changed accounting principles for National Government Employee Pensions Board (SPV) premiums which apply to doctors holding combined positions (doctors whose posts are shared between KI and Stockholm County Council, SCC), in accordance with directives from the Swedish National Financial Management Authority (ESV). Previously, KI entered SPV premiums to SCC as an non-governmental VAT-exempt remuneration. The amendment affects the item Other revenue from fees and remuneration, which has been reduced, see Note 2. Beginning in 2012, SCC’s pension premiums were reported as a cost reduction which affects the item employer’ contributions, pension premiums and other fees in accordance with laws and agreements, see Note 5. Corrections to the 2011 figures are made in the financial tables.

Exemption from certain provisions for universities and university colleges in accordance with the direct government funding directions

Universities and university colleges are granted exemption from the provision on settlement of funding in accordance with Sections 5 and 16 of the Swedish Appropriation Ordinance (1996:1189). Settlements against direct government funding and direct government funding items for funds paid out to educational institutions’ interest-bearing accounts at the Swedish National Debt Office must take place in connection with the monthly payments to the respective educational institution’s interest-bearing account at the Swedish National Debt Office.

Universities and university colleges are granted an exemption from Section 11 of the Swedish Direct government funding Ordinance (1996:1189) in that educational institutions may transfer both surplus production and unused funding caps (funding saving) to the subsequent budget year, up to a maximum of ten per cent of the funding cap, without specifically requesting the government’s consent. Universities and university colleges are granted an exemption from the provision in Chapter 2, Section 4, Paragraph 3 of the Swedish Annual Reports and Budget Documentation Ordinance (2000:605), which states that the annual report must include an account of key indicators. Universities and university colleges must instead provide information in accordance with Appendix 6. Universities and university colleges are granted an exemption from the requirement, as set out in Chapter 2, Section 4 of the Swedish Annual Reports and Budget Documentation Ordinance (2000:605), to submit a cash flow statement to the government as part of their annual report.

Information

In accordance with the Swedish National Financial Management Authority’s guidance on operations with several sources of funding (ESV 2006:28), each of the sources should be used in parallel. One of the reasons for this is to provide an accurate picture of how resources are used. KI has significant sources of external funding, primarily for grant-financed research, which involves funds having been applied for and granted for research into a specific subject. Funds are granted subject to contractual conditions and must be used in accordance with the plan set out in the contract. Grant funding received is not directly linked to performance, instead it is to cover the costs of conducting research into a specific subject, as identified by the researchers in their application. Taking this into account, KI does not apply the principle of parallel consumption completely since grant funding is usually granted to cover specific costs and notperformance.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Balance sheet (SEK in thousands) Direct government funding report Transferred balance brought forward

Allocation for the year under public service agreement

49,785

602,939

16.2:71 17 Dental care centre

Transferred balance Reallocated amount

Called in

Total available amount

652,724

633,368

19,356

1,338,788

95,360

16.2:71 18 Test following doctors’ preregistration practice

4,494

16.2:71 39 Quality-based allocation of resources

176

Total

100,030

580,378

6,004

Expenditure

carried forward

16.2:15 Bachelor’s and Master’s education (framework) 16.2:15 1 Funding cap

16.2:16 Research and doctoral education (framework) 16.2:16 2 Basic resources 16.2:71 Special mandate for universities and university colleges

16.2:72 Remuneration for clinical education and research 16.2:72 6 Karolinska Institutet 16.2:72 9 Commission to develop clinical education & research

6,004

Total

586,382

Total

49,785

2,628, 139

2,677,924

2,658,568

19,356

Terms of direct government funding 2:15, A.I. 1: Targeted Expansion of Nursing Programmes For 2013–2014, KI has been granted SEK 7.3 million per year to expand its nursing programmes. As KI was only informed about these funds in June 2013, it has not been possible to implement any expansion over the course of the year. KI will expand its nursing programmes by 30 places in 2014, which corresponds to SEK 9 million. The remainder of the direct government funding will be allocated to 55 full year places in specialist nursing programmes, specialising in medical and surgical care. 2013

2014

2015

2016

2017

Total by programme

2,273

3,030

758

9,090

Specialist nursing programme – medical care

960

1,970

2,929

Specialist nursing programme – surgical care

808

1,818

2,626

1,768

6,060

3,030

758

14,645

Nursing programme, campus

Total

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

FINANCIAL REPORT

Terms of Direct government funding 2:16, A.I. 2

Remuneration according to direct government funding directions (SEK in thousands)

Expenditure (SEK in thousands)

Balance carried forward (SEK in thousands)

Cancer

19,172

15,430

4,357

Diabetes

28,160

26,007

2,302

Epidemiology

10,057

10,081

Neuroscience

28,160

23,280

5,048

Stem cells and regenerative medicine

30,171

17,645

12,699

Care research

20,114

23,977

-3,704

137,198

116,420

20,778

Total

Care research: The deficit in care research is offset by the surplus from previous years. Stem cells: The surplus includes a recruitment package for one professorship and a visiting professorship The recruitment process is ongoing in both cases and will hopefully be concluded in the first half of 2014. Terms of Direct government funding 2:72, A.I. 9

Remuneration according to direct government funding directions (SEK in thousands)

Outcome (SEK in thousands)

850

1,052

Gothenburg University

912

Umeå University

875

Linköping University

703

Karolinska Institutet

1,612

Total

6,004

Uppsala University Lund University

Revenue headings report

Revenue 2,542,001

Patient fees connected to dentistry programme

2,219

Total

2,219

Chargeable activities where revenue is not at KI’s disposal Revenue 2013

Surplus/ deficit until 2011

Surplus/ deficit until 2012

196

199

Budget

Outcome

2,000

2,186

Costs 2013

Budget

Outcome

Surplus/ deficit 2013

Surplus/ deficit carried forward 2013

2,000

2,219

-34

165

Dental care centre

Patient fees

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

NOTES

Notes (SEK in thousands) Note 1. Revenue from Direct government funding 31/12/2013 Bachelor’s (first-cycle) and Master’s (second-cycle) education Research and doctoral (third-cycle) education

31/12/2012

733,398

697,466

1,322,196

1,291,751

581,990

576,330

Remuneration for clinical education and research

2,637,584 Table 1a Report of the number of full-time equivalent students (FTEs) and annual performance equivalents (APEs). Result for the period 01/01/2012 to 31/12/2012 Outcome FTEs

Outcome APEs

FTE remuneration (SEK in thousands)

APE remuneration (SEK in thousands)

2,565,547

Outcome Total remuneration

Education area

Humanities

837

Social sciences

459

463

Natural sciences

444

393

Technology Care Odontology

529

1,366

13,034

8,913

21,947

22,384

16,691

39,075

122

115

6,170

4,886

11,056

1,891

1,764

101,271

81,835

183,106

428

384

18,977

19,829

38,806

Medicine

2,639

2,443

157,963

177,818

335,781

Total

6,014

5,589

320,636

310,502

631,138

602,939 Funding cap (SEK in thousands) The report shows that the educational institution exceeds the funding cap by (SEK in thousands)

28,199

The report shows that the educational institution is below the funding cap by (SEK in thousands)

Table 2a Calculation of direct government funding savings and surplus production (SEK in thousands) A. Available funds (including agreed additional budget) Funding cap for the year + any direct government funding savings brought forward

602,939 49,785

Total (A)

652,724

B. Total result for first and second-cycle education Remuneration for APEs from December in the previous budget year Outcome total remuneration in accordance with Table 1

2,230 631,138

+ any use of previous surplus production

0 633,368

Total (B) Total (A-B) 1

19,356

Table. Direct government funding savings Total direct government funding savings carried forward (A-B) - any direct government funding savings above 10% of the funding cap Direct government funding savings carried forward

19,356 2

19,356

Table. Surplus production Total surplus production carried forward - any surplus production above 10% of the funding cap Surplus production carried forward

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

19,356 2

NOTES

Note 2. Revenue from fees and other remuneration 31/12/2013

31/12/2012

Section 4 of the Swedish Fees Ordinance

106,301

82,791

Revenue from commissions

269,247

364,613

Remuneration from SCC in accordance with the ALF/RDE Contract.

132,461

32,566

15,725

Revenue from fees and remuneration in accordance with

Remuneration from non-governmental wage agreements not covered by the ALF Contract Other revenue from fees and remuneration, governmental Other revenue from fees and remuneration, non-governmental

39,880

32,325

145,923

258,452

709,537

770,747

The increase in Section 4 revenue is due to increased rental income and increased tuition fees for students from third countries. The accumulated surplus of chargeable activities amounts to SEK 86,305,000, which represents 21.6 per cent of the operation’s turnover, SEK 398,722,000. Part of the surplus will be used within the scope of enhanced collaboration with SCC in Public Health Sciences. It will also be used for the co-financing of projects where full cost coverage is not achieved. The surplus will be used, for example, to develop new courses within the framework of contract education.

Activity

Surplus/ deficit until 2011

Surplus/ deficit 2012

Revenue 2013

Costs 2013

Surplus/ deficit 2013

Accumulated surplus/ deficit carried forward 2013

Education at first or second-cycle level Commissioned education

4,642

-1,668

6,780

7,761

-981

1,993

Commissioned education

9,156

10,873

54,653

58,494

-3,841

16,188

Education for students who are obliged to pay tuition fees

-3,416

-171

9,263

7,551

1,712

-1,875

Total

10,382

9,034

70,696

73,806

-3,110

16,306

Vocational college, post-secondary vocational education and training etc.

Research or education at third-cycle level Commissioned research

54,034

22,207

290,310

296,038

-5,728

70,513

Total

53,034

22,207

290,310

296,038

-5,728

70,513

Activities where full cost coverage requirements do not apply Swedish Scholastic Aptitude Tests Letting apartments 1 - exchange programmes and visiting researchers

214

-19

-245

728

978

-250

-514

36,774

37,716

37,966

-250

-514

Letting apartments 1 - Government Decision (U2010/4277/UH) Optician centre Other activities in accordance with Appendix 4 2 Total

-19

-245

¹ Karolinska Institutet does not deal with the actual letting of accommodation for international students and visiting researchers, but procures this as a service from Karolinska Institutet Housing AB (formerly University Accommodation Center AB, UAC), a subsidiary of KI Holding AB. KI paid a fee of SEK 6,192,000 for this in 2013 (SEK 3,492,000). The increase of this fee is due to a supplemental agreement covering the rental of 70 homes in Vårberg. In addition, KI has had miscellaneous costs of SEK 853,000 (SEK 261,000). These costs are covered by direct government funding. As letting takes place in this way, it is not classified in KI’s accounts as fee-financed activities. KI Housing makes 308 (277) apartments available to KI, of which 63 (64) are researcher apartments and 213 (213) are student rooms. KI Housing has let apartments/rooms to a total of c. 825 (808) international student and visiting researchers over the course of 2013. The occupancy rate was around 87 per cent. In addition, KI let accommodation to visiting researchers for a total of SEK 214,000 (SEK 339,000) in 2013. The cost is assessed to be the same. The need for apartments/rooms is expected to increase in line with increased international exchanges and collaboration. ² KI let premises to external tenants for a total of SEK 37,716,000 (SEK 42,280,000) in 2013. There is no separate cost accounting for this activity, but full cost coverage is taken as the starting point, which is why the cost is specified in line with the revenue. KI’s policy is to rent entire buildings if possible in order to have full usage rights of the premises in its portfolio. Unused premises are then used as a reserve in case of future needs and are rented out.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

NOTES

Note 3. Revenue from grants 31/12/2013

31/12/2012

Revenue from grants from other Government agencies

1,034,761

983,626

Revenue from grants, non-Governmental

1,363,204

1,270,792

2,397,965

2,254,418

Note 4. Financial income 31/12/2013

31/12/2012

Interest on interest-bearing account at the Swedish National Debt Office

32,052

46,971

Capital gains on the disposal of financial fixed assets

13,043

2,742

5,635

5,189

50,730

54,902

Other financial income

The reduction in interest income at the Swedish National Debt Office is due to a lower rate of interest on the interest-bearing account in 2013 compared with 2012. The annual average interest rate on the interest-bearing account for 2013 was 1.01 per cent (1.47 per cent).

Note 5. Staff costs 31/12/2013

31/12/2012

1,912,948

1,833,872

925,333

894,596

Educational grants

72,700

70,061

Other staff costs

79,324

72,696

2,990,305

2,871,225

Salary costs excluding employer's contributions, pension premiums and other fees in accordance with laws and agreements Employer's contributions, pension premiums and other fees in accordance with laws and agreements

In 2013, staff costs increased by SEK 119.1 million (4.1 per cent), compared with the previous year. In October 2013, KI had 4,778 employees – equivalent to 4,283 full-time time employees – an increase of 91 (2.2 per cent) when compared with the same period in 2012.

Note 6. Premises costs At the end of the year, KI’s premises portfolio totalled 218,870 m² (213,881 m²). Premises costs rose in total by approximately SEK 74 million compared with 2012. In addition to the indexed increase in rents, the cost increase is the result of expansion of operations and several new buildings coming into use (further information in the section Common to the Entire Organisation).

Note 7. Other operating costs 31/12/2013

31/12/2012

Remuneration for clinical education and research (ALF funding)

580,378

574,400

Travel, conferences, information and entertainment

140,201

135,537

Purchases of goods for laboratory activities

283,356

270,784

Bought-in services

498,146

470,417

Other goods and services

153,440

153,402

Other operating costs

188,970

164,373

1,844,491

1,768,913

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

NOTES

Note 8. Financial expenses Interest on loans at the Swedish National Debt Office Interest on overdue payments Exchange rate losses

Other financial expenses

31/12/2013

31/12/2012

4,975

5,917

309

327

3,593

2,300

772

467

9,649

9,010

The reduction in interest expenses at the Swedish National Debt Office is due to a lower rate of interest on the interest-bearing account in 2013 compared with 2012. The annual average interest rate on the interest-bearing account for 2013 was 1.01 per cent (1.47 per cent).

Note 9. Collection of general revenue The balance relates to the net change in potential bad debt losses for non-payment of patient fees at the Institute of Odontology.

Note 10. Transfers Other funds received to finance grants 31/12/2013

31/12/2012

Funding received from municipalities and county councils

2,195

3,026

Funding received from private companies

3,892

3,368

Funding received from international organisations

4,958

4,129

Funding received from EU institutions

15,060

13,017

Funding received from foundations

33,196

31,589

Funding received from others sources

27,818

29,532

87,119

84,661

31/12/2013

31/12/2012

-4,833

-4,743

Grants distributed Grants paid to county councils for consumption Grants paid to EU countries for consumption

-698

-86

Grants paid to other countries and internal organisations for consumption

-7,661

-5,565

Grants paid to other organisations for consumption

-7,559

-951

Grants paid to individuals for consumption

-59,875

-58,583

-80,626

-69,928

31/12/2013

31/12/2012

-4,310

-11,121

Where of grants paid which were funded from the EU budget European Union European Research Council (ERC)

64â&#x20AC;&#x2021;

-10,750

-1,896

-15,060

-13,017

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

NOTES

Note 11. Change in capital Change in capital by area, SEK in thousands Change in capital

Expenditure (SEK in thousands)

Balance carried forward (SEK in thousands)

104,756

45,898

150,654

23,003

-4,822

18,181

127,759

41,076

168,835

1,028,974

-36,531

992,443

76,241

-5,728

70,513

1,105,216

-42,260

1,062,956

55,458

8,825

64,282

238

-110

-34

-144

Total

55,586

8,791

64,377

Total

1,288,561

7,606

1,296,167

Activity First and second-cycle education

Education in accordance with the public service agreement Commissioned activities Total

Research/third-cycle education

Research and doctoral education Commissioned research Total

Other activities

Profit/loss from holdings in associated companies and subsidiary Art, not related to activities Collection of general revenue

Change in capital for the year by activity, SEK in thousands Activity

Activities funded by direct government funding Activities funded by fees Activities funded by grants Profit/loss from holdings in associated companies and subsidiary Other activities Total change in capital for the year

31/12/2013

31/12/2012

10,372

42,118

-10,551

31,412

-1,006

65,997

8,825

-31,542

-34

7,606

107,989

31/12/2013

31/12/2012

32,972

38,500

Note 12. Intangible fixed assets Applied depreciation periods: 5 years

Opening Balance Acquisition value Acquisitions for the year

4,110

,389

Minus acquisition value of disposed of/sold rights

-6,625

-5,917

Closing Balance Acquisition value

30,456

32,972

-26,172

-29,957

6,625

5,917

Opening Balance Accumulated depreciation Minus accumulated depreciation of disposed of/sold rights Depreciation for the year Closing Balance Accumulated depreciation Book value

-2,183

-2,132

-21,729

-26,172

8,727

6,800

Disposals primarily relate to KIâ&#x20AC;&#x2122;s old web portal, ki.se, a total of SEK 6,086,000

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

65â&#x20AC;&#x2021;

NOTES

Note 13. Expenditure for improvements to leased property Applied depreciation periods: 10 years Opening Balance Acquisition value

31/12/2013

31/12/2012

85,025

102,278

Acquisitions for the year

Transfers from fixed assets under construction

Minus acquisition value of disposed of/sold equipment

-17,253

Closing Balance Acquisition value

85,025

Opening Balance Accumulated depreciation

-42,395

-41,205

Minus accumulated depreciation of disposed of/sold equipment

7,814

-8,303

-9,004

-50,698

-42,395

34,327

42,631

Capital gain

Capital loss

9,429

31/12/2013

31/12/2012

2,198,720

2,010,676

317,299

224,460

51,539

20,859

Depreciations for the year

Closing Balance Accumulated depreciation Book value Assets disposed of/sold

Note 14. Machinery, equipment, fixtures and fittings etc. Applied depreciation periods: 3 years, 5 years, 10 years Opening Balance Acquisition value Acquisitions for the year Transfers from fixed assets under construction Minus acquisition value of disposed of/sold equipment

-53,921

-57,276

Closing Balance Acquisition value

2,513,636

2,198,720

Opening Balance Accumulated depreciation

-1,535,799

-1,405,087

Minus accumulated depreciation of equipment disposed of/sold Depreciation for the year

Closing Balance Accumulated depreciation Book value

50,919

48,143

-200,883

-178,855

-1,685,763

-1,535,799

827,873

662,921

Assets disposed of/sold Capital gain

Capital loss

2,979

8,729

31/12/2013

31/12/2012

65,272

31,438

Note 15. Fixed assets under construction Opening Balance Acquisition value Acquisitions for the year

30,738

54,694

Transfer to assets account

-51,539

-20,859

Accumulated acquisition value

44,472

65,272

Fixed assets under construction include improvements to KIâ&#x20AC;&#x2122;s campus areas. These projects run for several years, that is why the transfer to the assets account may be lower than the opening balance.

66â&#x20AC;&#x2021;

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

NOTES

Note 16. Holdings in associated companies and subsidiary 31/12/2013

Karolinska Institutet Holding AB (100 %) Nominal value: 3,000 at SEK 100 each

31/12/2012

300

64,282

55,458

Book value Shares in KI Holding are valued at SEK 9 million higher than at the previous year end. According to preliminary, as yet unaudited accounts for 2013, KI Holding AB reports a group turnover of SEK 48.9 million, which is SEK 6.2 million higher than the previous year. The group has made an operating profit of SEK 8.9 million, which is SEK 41.9 million better than the previous year. Holdings in associated companies account for SEK 36.9 million of this improvement. The previous yearâ&#x20AC;&#x2122;s write-down of the holding in Karolinska Development AB has been reversed since the share price rose. The reversed depreciations amount to SEK 19.0 million. For a more detailed description of Karolinska Institutet Holding AB, see the section entitled Collaboration.

Note 17. Other long-term securities holdings (relates to asset management) 31/12/2013

31/12/2012

Book value

158,015

143,607

Market value

180,182

152,534

Book value

68,123

92,645

Market value

72,763

99,331

Holdings

Bonds etc.

The fund portfolio had a positive value change of 9.8 per cent in 2013. The relative return on investment in comparison to the market index was negative (-2.8 per cent). This is due to factors including ethical restrictions and exposure to shares in emerging markets.

Note 18. Receivables from other Government agencies 31/12/2013

31/12/2012

Governmental accounts receivable

27,556

13,430

VAT receivables

87,057

81,325

335

259

114,948

95,014

31/12/2013

31/12/2012

118

329

Tax account

Note 19. Other receivables Petty cash Travel advances Salaries paid in advance Receivables combined positions Other receivables

373

874

303

31/12/2013

31/12/2012

135,526

130,867

Note 20. Prepaid expenses Prepaid premises expenses Other prepaid expenses

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

26,102

20,611

161,628

151,478

67â&#x20AC;&#x2021;

NOTES

Note 21. Accrued grant revenue 31/12/2013

Accrued grant revenue , other government agencies Accrued grant revenue , non-government

31/12/2012

33,771

25,584

222,282

182,149

256,053

207,733

Receivables relating to accrued costs are reported here for activities funded by grants where remuneration is received afterwards and where it is confirmed by agreements/contracts.

Note 22. Other accrued revenue 31/12/2013

31/12/2012

Accrued contract revenue

9,859

8,230

Accrued revenue for the Science for Life Laboratory

6,418

Other accrued revenue

2,949

2,282

19,226

10,512

Under the item Accrued contract revenue, receivables relating to accrued costs are reported for contract-financed activities where remuneration is received afterwards and where it is confirmed by agreements/contracts.

Note 23. Settlement with the Government 31/12/2013

31/12/2012

-18,803

-16,690

-2,219

-2,114

General revenue Opening Balance Reported against revenue headings (-) Funds from interest-bearing account credited to revenue headings (+)

Liabilities relating to General revenue

-21,022

-18,803

-49,785

-90,132

2,658,392

2,585,348

176

-2,628,139

-2,573,813

Direct government funding in interest-bearing flows Opening Balance Reported against direct government funding (+) Quality-based allocation of resources Direct government funding funds credited to the interest-bearing account (-) Repayment of direct government funding funds

28,812

-19,356

-49,785

18,458

16,372

Deposits in non-interest-bearing flows (+)

2,143

2,162

Payments in non-interest-bearing flows (-)

-76

Liabilities related to direct government funding in interest-bearing flows Other receivables/liabilities on the government’s central account at the Riksbank Opening Balance

Claims on the government’s central account at the Riksbank Balance

20,601

18,458

-19,778

-50,130

Of the previous years’ direct government funding savings within first-cycle and second-cycle education, SEK 30.4 million has been returned through KI exceeding the funding cap at settlement of FTSs and APEs.

Note 24. Balance of the interest-bearing account at the Swedish National Debt Office Balance of the interest-bearing account at the Swedish National Debt Office Of which short-term liquidity needs

31/12/2013

31/12/2012

3,182,339

3,244,073

Credt granted, but not unused, on the interest-bearing account at the Swedish National Debt Office is amounting to SEK 153.8 million.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

NOTES

Note 25. Agency capital Government capital

Share in earnings in subsidiaries

5,238

82,000

Opening Balance Previous yearâ&#x20AC;&#x2122;s allocation Corrected Opening Balance

5,238

Change in Change in capital capital according to the brought for- statement of finanward cial performance 1,093,334 107,989

Total agency capital 1,288,561

-31,542

139,531

-107,989

50,458

1,232,865

1,288,561

Change in equity, subsidiaries From the National Public Art Council

Change in capital for the year Closing Balance

7,606

5,238

50,458

1,232,865

7,606

1,296,167

-31,542

139,531

-100,383

7,606

Change during the year Change in capital by business area is detailed in Note 11.

Note 26. Provisions for pensions and similar obligations Opening provision Change in pension provisions for the year

31/12/2013

31/12/2012

7,438

11,548

4,303

-2,530

Pension payments for the year

-1,442

-1,579

Closing provision

10,299

7,438

31/12/2013

31/12/2012

Note 27. Other provisions Disposal of radiation source

2,000

Continued professional development initiatives

29,083

37,776

Closing provision

31,083

39,776

31/12/2013

31/12/2012

442,336

400,245

Note 28. Loans at the Swedish National Debt Office Opening Balance New loans

227,964

175,100

Repayments for the year

-129,090

-133,009

Liabilities to the Swedish National Debt Office

541,210

442,336

Granted loan framework at the Swedish National Debt Office

542,000

520,000

Note 29. Accrued expenses 31/12/2013

31/12/2012

Accrued salaries

27,048

21,171

Holiday pay liabilities

90,011

83,343

Accrued expense to the National Government Employee Pensions Board for pension funds Other accrued expenses

3,032

24,000

25,484

141,059

133,031

The cost of salary increases in conjunction with the salary review are included in the item accrued salaries. The result of the salary review on 1 October 2013 was an average increase of 2.4 per cent. This is paid out in January 2014.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

69â&#x20AC;&#x2021;

NOTER

Note 30. Unexpended grants 31/12/2013

Unexpended grants, other government agencies Unexpended grants, non-government

Unexpended grants asset management

31/12/2012

830,419

786,534

1,402,251

1,313,438

212,079

213,030

2,444,749

2,313,002

These liabilities relate to non-accrued costs for grant-financed activities where remuneration is paid in advance.

Rate of use unexpended government grants Grants for the year, other government agencies Unexpended grants, other government agencies Accrued grant revenue , other government agencies

31/12/2013

31/12/2012

1,087,602

1,025,397

830,419

786,534

33,771

25,584

Rate of use

1,37

1,35

Used within a number of months

8,79

8,91

Usage SEK in thousands, 0–3 months

283,426

264,968

Usage SEK in thousands, 3-12 months

546,992

521,566

Usage SEK in thousands, 1–3 years

Usage SEK in thousands, >3 years

This note has been prepared in accordance with HfR’s (the universities’ forum for accounting issues) accounting advisors’ recom-mendations. The method involves a standardised calculation of the average turnover rate/rate of use The rate of use for activities financed by government grants is judged, all in all, to be linear.

Note 31. Other prepaid revenue 31/12/2013

Prepaid contract revenue, other government agency Prepaid contractrevenue, non-government Other prepaid revenue, other government agency Other prepaid revenue, non-government

31/12/2012

41,922

54,372

218,072

239,661

13,451

547

6,896

8,163

280,341

302,743

Prepaid contractrevenue relates to non-accrued costs for contract-financed activities where remuneration is paid in advance.

Note 32. Contingent liabilities Contingent liabilities

31/12/2013

31/12/2012

40,644

183,900

The contingent liabilities for 2013 relate to new commitments made to Akademiska hus concerning the adaptation of business activities. The previous year’s contingent liabilities lapse because KI have entered into a rental agreement valid for 25 years with Akademiska hus, following permission being granted by the government.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

INTERNAL CONTROL

INTERNAL CONTROL Karolinska Institutet (KI) is encompassed by the Internal Control Ordinance (2007:603). In view of the established risk assessment and the implemented and planned work with approved control activities, the Board of KI makes the assessment in the annual report that internal control at KI is satisfactory. This year’s work has been based on previously agreed rules and guidelines for internal control at KI, where a simplified risk assessment has been carried out during the financial year 2013. The basis for the risk assessment has been KI’s commission in accordance with the Higher Education Act and Ordinance, direct government funding directions and the Vice-Chancellor’s focus areas. In addition, significant observations in conjunction with internal and external audit have been taken into account. Over the course of the year, the Board have looked into twelve risk areas, in which decisions have been made concerning targeted control activities: • limited opportunities for clinical education, • limited opportunities for clinical research, • deficient medical informatics in the collaboration between KI/SCC, • insufficient access to teachers, • the assessed deficient quality of external evaluations of study programmes, • research fraud, • unauthorised data access and system crashes, • reclamations resulting from deficient management of fundings and fallible reporting to external funding sources, • deficient research documentation, • deficient adherence to the Public Procurement Act, • a lack of modern technology platforms and tools in study programmes and • limited regulations concerning register data.

beginning of 2014. Guidance on information security has been drawn up and distributed to every employee and student and to others associated with the university. The Swedish National Audit Office produced an audit report in 2012 containing observations concerning the procurement and purchasing process. KI has constantly reported on the measures within this area, taking in action plans, preparations for the implementation of an e-commerce system and follow-up and information activities. KI’s centralised procurement and purchasing function has been reinforced with extra personnel over the course of financial year 2013. In 2012, the Office of the Chancellor of Justice (JK) expressed its serious criticism of KI with regard to deficiencies in recordkeeping and case management. JK resolved in May 2013 to conclude their review in the light of the measures that had been taken and reported throughout 2012 and 2013. Over the course of 2013, the Swedish National Archives have carried out an inspection of archive keeping at KI and have provided directions in a number of areas. At the close of financial year 2013, KI has submitted a report to the Swedish National Archives concerning the measures that have been taken and are planned for the future. The Vice-Chancellor came to a decision concerning activities in KI’s annual plan for 2013–2014 in May 2013. The aim is to improve the efficiency, assure the quality and integrate the process of internal control, operational planning and follow-up. This work has resulted in KI’s first comprehensive operational plan. Approved by the Board of KI, it contains instructions, budgets and also an integrated risk assessment for the subsequent year.

Over the course of the year, previously approved control activities have been followed up on two occasions, with significant results having been reported to the Board. Based on the Swedish National Audit Office’s previous audit report concerning the internal control of information security that was submitted in 2011, KI have taken the measures that have been reported in conjunction with the ongoing review of the agency. New information security regulations have been drawn up and these were published in October 2013. Recruitment of an information security coordinator took place at the end of the year, with the position commencing on 1 January 2014. In autumn, planning took place ahead of the executive group’s risk assessment of information security at the

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

THE UNIVERSITY BOARD

The University Board Remuneration paid to the Board of Karolinska Institutet in 2013 and details of the members other roles (the commissions listed are board memberships and council memberships for other government agencies, as well as assignments like board members of Swedish and foreign limited companies). Name:

Other commissions

Susanne Eberstein, Chair

Västernorrland Police Board, Chair Swedish National Police Board, member Swedish Commission on Security and Integrity Protection, member Judicial Appointments Board, member

22,000

Sveriges Utbildningsradio AB, Chair Svenska Rymd AB, SSC, member MittMedia Förvaltnings AB, Chair Promedia Tidnings AB, member SwedNanoTech AB, Chair Lars Leijonborg AB, Chair

44,000

up to and incl. 30/04/2013

Lars Leijonborg, Chair fr.o.m. 2013-05-01

Salary/Fee, SEK

Anders Hamsten, Vice-Chancellor

Karolinska Institutet Holding AB, member Doctor Åke Olsson’s Foundation for Haematological Research, member Stockholm School of Entrepreneurship, member Petrus and Augusta Hedlund’s Foundation, member

Annika Andersson, Deputy Chair

Pantor Engineering AB, Chair

28,000

Dan Andersson

Swedish Cancer Society’s finance committee, member

28,000

Elias Arnér

Biochimica et Biophysica Acta - General Subjects, Elsevier, editor IMCO Corporation Ltd AB, member and shareholder PRIMA Barn- och Vuxenpsykiatri AB, member

Anders Blanck

Swedish Anti-corruption Institute, member Swecare AB, member Swecare Foundation, member

28,000

Susana Borrás

Danish Council for Research Policy, member

18,670

1,529,287

783,689

From and incl. 01/05/2013 Eva Fernvall up to and incl. 30/04/2013

eHealth Institute, Linnaeus University, Chair IQ, Ssubsidiary of the Swedish Alcohol Retail Monopoly, member

Eskil Franck

Government appointed special investigator for more effective methods against violent extremism

Laura Fratiglioni

Board for National Infrastructure ESS/SHARE, Chair International Oversight Committee/Canadian Longitudinal Study on Ageing, Canadian Institutes of Health Research (CIHR), member Scientific Advisory Committee of the EU Joint Programme, Neurodegenerative Disease Research, member

From and incl. 21/03/2013

9,340

28,000

1,074,652

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

THE UNIVERSITY BOARD

Name:

Other commissions

Hans-Gustaf Ljunggren up to and incl. 28/02/2013

Scientific Advisory Board, Umeå Centre for Microbial Research (UMCR), member International Advisory Board, Hannover Biomedical Research School, member Board of the Scandinavian Foundation for Immunology, member Society for Natural Immunity, President CellProtect Nordic Pharmaceutical AB, founder and shareholder Molecular Immunology, associate editor Scandinavian Journal of Immunology, deputy editor-in-chief Immunology and Cell Biology, editorial board, member

Torbjörn Rosdahl

County Council Board, SCC, Chair Landstingshuset i Stockholm AB, Chair SLL Internfinans Stockholm AB, Chair Owners’ committee of Transito AB, member Council for the Stockholm-Mälar Region, member AB SOLOM (Sollentuna Omsorg), member

28,000

Charlotte Strömberg

Castellum AB (publ), Chair Boomerang AB, member Fourth Swedish National Pension Fund, member Intrum Justitia AB (publ), member Skanska AB (publ),member Swedbank AB (publ), member

18,670

fr.o.m. 2013-05-01

Salary/Fee, SEK

949,414

Marie Wahren-Herlenius

Scandinavian Society for Immunology, Chair Scandinavian Foundation for Immunology, member Swedish Heart-Lung Foundation’s Research Council, member Konung Gustaf V:s 80-årsfond, member and Chair of the scientific committee Tore Nilsson’s Foundation, member Rocognition AB, member

Kerstin Tham, co-opted member

Board of Karolinska University Hospital, co-opted member Board of Flemingsberg Science Foundation, member Board of Karolinska Institutet University Press, member

Erik Hellsing

Café Partner Scandinavia AB, deputy member

Arash Hellysaz

Hope Group AB, deputy member

Hampus Eksell

No external commissions

30,330

Elin Ekeroth

No external commissions

Viktoria Malas

No external commissions

845,173

1,246,907

39,200 291,660

Members from and incl. 01/01/2014

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Photo: Ulf Sirborn

THE UNIVERSITY BOARD

Konsistoriet The Board of Karolinska Institutet From the bottom, row 1:Hamsten, Anders Hamsten, Vice-Chancellor; Andersson,Lars Deputy Chair; Lars Leijonborg, Chair; Arash(stuNerifrån, rad 1: Anders rektor; Annika Andersson,Annika vice ordförande; Leijonborg, ordförande; Arash Hellysaz Hellysaz (students’ representative); Elin Ekeroth (students’ representative). dentrepresentant); Elin Ekeroth (studentrepresentant) Rad (ständigt adjungerad); Charlotte Strömberg; Susana Borrás Laura Fratiglioni (lärarrepresentant); Row2: 2:Kerstin KerstinTham, Tham,prorektor Pro-Vice-Chancellor (always co-opted); Charlotte Strömberg; Susana; Borrás; Laura Fratiglioni (faculty’s Dan Andersson Dan Andersson. representative); Row 3: Eskil Franck; Viktoria Malas (students’ representative); Christina Hammarstedt (staff representative); Gunnar Stenberg Rad 3: Eskil Franck; Viktoria Malas (studentrepresentant); Christina Hammarstedt (personalrepresentant); Gunnar Stenberg (per(staff representative*); Anders Blanck; Elias Arnér (faculty representative); Karl Bodell (staff representative*). sonalrepresentant); Anders Blanck; Elias Arnér (lärarrepresentant); Karl Bodell (personalrepresentant) Not present: Torbjörn Rosdahl; Marie Wahren-Herlenius (faculty representative). Ej närvarande: Torbjörn Rosdahl; Marie Wahren-Herlenius (lärarrepresentant); * Staff representatives have no voting right

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

THE UNIVERSITY BOARD

Resolution on the annual report and assessment of internal control The University Board hereby resolve to submit the annual report for 2013. We confirm that the annual report provides a true and fair impression of the authority’s results, costs, revenue and of the agency’s financial position. We also judge the authority’s internal control to be satisfactory. Stockholm, 19 February 2014

Lars Leijonborg, Chair

Eskil Franck

Anders Hamsten, Vice-Chancellor

Laura Fratiglioni

Annika Andersson

Arash Hellysaz

Dan Andersson

Viktoria Malas

Elias Arnér

Torbjörn Rosdahl

Anders Blanck

Charlotte Strömberg

Susana Borrás

Marie Wahren-Herlenius

Elin Ekeroth

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

KEY INDICATORS

Key indicators 2013

2012

2011

2010

2009

6,014 147 5,589 158 51 373 55% 45% 2,090 59% 41% 595 375 2,41 4,24 306 12

5,885 154 5,307 170 34 438 57% 43% 2,165 61% 39% 572 380 3.03 4.26 359 14

5,815 146 5,351 159 10 409 61% 39% 2,133 62% 38% 544 340 2.56 4.21 349 14 4,090 1,043

5,524 144 5,050 157

5,595 143 5,012 159

450 62% 38% 2,076 62% 38% 519 347 2.05 4.21 367 21 3,901 1,062

420 61% 39% 2,028 61% 39% 515 342 2.38 3.94 392 17 3,801 1,022

4,283 4,736 827 46% 54% 717 42% 58% 373 28% 72%

4,192 4,716 846 46% 54% 714 41% 59% 367 27% 73%

4,109 4,699 845 47% 53% 707 41% 59% 347 26% 74%

3,944 4,545 801 46% 54% 665 40% 60% 331 24% 76%

3,875 4,382 812 47% 53% 634 38% 62% 328 21% 79%

5,796 991 88% 12% 4,805 37% 63% 5,797 52% 13% 3,386 5,165 2,445 8 1,296 64

5,646 954 87% 13% 4,692 37% 63% 5,506 52% 12% 3,118 5,017 2,313 108 1,289 56

5,340 926 87% 13% 4,415 37% 63%

5,253 851 89% 11% 4,402 36% 64%

4,880 853 89% 11% 4,027 33% 67%

5,188 53% 11% 2,916 4,899 2,277 145 1,196 94

4,994 52% 11% 2,761 4,658 2,224 255 1,079 129

4,734 53% 12% 2,791 4,105 2,030 149 812 122

Education and research

FTE, full time equivalent, students1 Cost per FTE student (SEK thousand)* APEs1 Cost per APE (SEK thousand)* Number of fee-paying students New doctoral admissions – women – men Doctoral students, total > 10% activity – women – men Doctoral students with employment (FTEs) Doctoral students with grant (FTEs) Average study time, licentiate students (net) Average study time, doctoral students (net) Doctoral degrees awarded Licentiate degrees awarded Peer-reviewed scientific publications ** Cost per peer-reviewed scientific publication (SEK thousand)*** Staff

FTEs Average staff Teaching staff: (FTEs) – women – men Teaching staff with doctoral degrees (FTEs) – women – men Professors (FTEs) – women – men Finance

Revenue, total (SEK million), of which Bachelor’s and Master’s education (SEK million) – direct government funding (%) – external revenue (%) Doctoral education and research (SEK million) – direct government funding (%) – external revenue (%) Costs, total (SEK million) – Staff – Premises Premises costs2 per m2 (SEK) Balance sheet total (SEK million), of which – unexpended grants – change in capital for the year – administrative capital (incl. change in cap. for the year) – of which subsidiaries (KI Holding AB)

1 Excluding contract education and contracted courses. 2 As stated in the revenue statement. * Including costs incurred within funding for medical training and research and the dental care centre. ** Figure not given owing to delay in registration, which would otherwise distort the statistics. The figures for 2008–2010 have also been adjusted due to the aforementioned delay in registration. Also affects cost per publication. *** Including costs incurred within funding for medical training and research.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

COSTS

Appendix: Costs As with previous years, KI reports the following key performance indicators: • • • •

cost per full-time equivalent student (excluding contract education and commissioned education), cost per annual performance equivalent (excluding contract education and commissioned education), cost per peer-reviewed academic publication, cost of a doctoral student with an educational grant or employment at KI.

Definitions Full-time equivalent students and annual performance equivalents are the performances that have been carried out over the course of the year and are defined in accordance with public service agreement. The costs reflect the reported costs for the year within the area Bachelor’s and Master’s education funded by direct government funding. The costs also include costs funded by grants and fees, which are associated with the activity. However, contract education and commissioned education are not included. It should be noted that full-time students and annual performance equivalents have been related to costs individually. Therefore, it is not possible to relate the costs per full-time equivalent student and annual performance equivalent to the ”price tags” used in the government’s allocation of resources to the educational institutions. In this context, it should be noted that the costs are also included in the clinical sections of the medical and speech therapist education (equivalent to the ALF direct government funding) and the dentistry education (the dental care centre). The measurements of costs per full-time equivalent student and annual performance equivalent are deemed to be relatively secure, as the constituent elements relate to the current year and are well-established. Cost per peer-reviewed scientific publication includes all costs related to research and doctoral education, including contract research. No differentiation is made between the actual course components in doctoral education because this cannot be determined from the accounting. KI has chosen to include the document types articles and review articles from its bibliometric database based on data from Thomson Reuters’ citation databases (Web of Science) in the term academic publication.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Under key indicators, KI has also chosen to report the number of published articles unfractionated (i.e. without taking into account the proportion of a published article attributable to authors at the educational institution in question). KI has not reported any details regarding published articles for the past year (2013) as there is a reporting delay. The indicator “cost per peer-reviewed scientific publication” should be viewed with caution as there is no direct link between the year’s costs and the number of articles published the same year. The research work involved in an article may have taken many years. In view of the above, this indicator should be regarded as an approximate value. Finally, it should be emphasised that these performance indicators do not say anything about the quality of operations. Cost of a doctoral studentwith an educational grant or employment at KI: the cost of educational maintenance for doctoral students employed on doctoral studentships and with educational grants is a weighted average. These costs can be taken directly from the finance and personnel accounting system. In addition, there are the following costs: • supervision, • operating costs, • premises, • equipment (depreciation costs), • indirect costs. Supervision is estimated at approx. 20 per cent of a FTE employee (based on a survey). The average cost of a supervisor’s salary can thus be estimated. Operating and premises costs, along with depreciation are proportioned based on the number of annual FTE employees, including doctoral students with education grants within the operational area research and education at the doctoral level. The same calculation is used for doctoral students as for supervisors. The total cost for a doctoral student including supervisor costs can thus be estimated after overheads have been added for indirect costs. The data is based in part on assumptions, which is why the cost should be viewed as approximate. A table of costs and comments can be found under the section doctoral education.

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

TABLES

Table 1 First-year places (planned) in study programme, total and per place Beginner’s programme Occupational therapy Audiology Biomedicine Biomedical lab. science Public health sciences Speech and language pathology Medicine Optometry Psychology Radiography Physiotherapy Nursing Dental hygiene Dentistry Dental technology Continuation programme Midwifery Psychotherapy Specialist nursing Odont. prophylactics Toxicology Master’s programme (1 year) Master’s programme (2 years) Total

2010 total /place 72 2.2 16 1.3 50 1.2 70 1.0 30 1.2 28 4.4 306 8.7 45 0.7 70 8.1 40 2.2 120 6.1 150 3.8 40 4.9 85 4.9 20 3.7

2011 total /place 72 2.1 15 1.7 50 1.0 60 1.0 30 1.1 4.9 276 7.8 45 0.6 40 7.0 40 2.4 120 5.8 380 4.0 40 5.3 75 4.8 20 2.4

2012 total /place 171 2.4 51 3.2 53 1.1 109 1.6 122 4.4 2,460 8.0 118 2.6 461 6.6 69 1.7 607 5.1 1,278 4.3 246 6.2 417 4.9 -

2013 total /place 185 2.6 70 4.4 57 1.1 126 2.1 143 5.1 2,565 8.2 131 2.9 660 9.4 108 2.7 689 5.7 1,272 4.2 282 7.1 458 5.4 -

64 16 511 20 65 269

5.3 1.6 2.7 1.3 3.5 2.8

64 16 449 20 135 120

5.4 1.4 2.9 1.0 1.8 2.0

340 32 1,513 18 182 571

5.3 2.0 2.7 0.7 2.4 2.3

332 23 1,529 27 586 334

5.2 1.4 2.7 1.1 2.4 2.3

2.087

4.1

2,097

3.8

8,818

3.9

9,577

4.2

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

TABLES

Table 2 First-year students (registered for 1st term), total and percentage of women (%)

Beginner’s programme Occupational therapy Audiology Biomedicine Biomedical lab. science Public health sciences Speech and language pathology Medicine Optometry Psychology Radiography Physiotherapy Nursing Dental hygiene Dentistry Dental technology Continuation programme Midwifery Psychotherapy Specialist nursing Odont. prophylactics Toxicology Master’s programme (1 year) Master’s programme (2 years) Total

2010 total women 88 91 25 76 74 65 83 77 46 85 34 100 317 56 52 83 86 72 51 76 153 63 179 85 48 94 92 62 33 82

2011 total women 92 84 21 71 77 58 90 82 41 93 33 94 328 51 40 90 89 73 56 80 148 69 358 82 46 89 91 58 30 70

2012 total women 94 86 24 71 75 64 95 78 32 84 325 48 62 85 84 65 50 74 151 74 367 86 49 96 97 70 -

2013 total women 92 89 25 68 77 68 101 81 33 82 320 49 59 75 85 59 57 70 149 63 354 86 45 98 96 65 -

68 17 596 27 68 308

99 82 87 81 69 67

74 16 563 21 163 235

97 88 85 100 90 70

63 16 633 23 73 257

100 75 89 100 81 68

67 16 647 23 276 141

100 88 89 87 82 67

2,445

2,612

2,570

2,663

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

TABLES

Table 3 Students, full-time equivalents (FTE), total and percentage of women Beginner’s programme Occupational therapy Audiology Biomedicine Biomedical lab. science Public health sciences Speech and language pathology Medicine Medical informatics Optometry Podiatry Psychology Radiography Physiotherapy Nursing Dental hygiene Dentistry Dental technology Continuation programme Midwifery Psychotherapy Specialist nursing Odont. prophylactics Toxicology Master’s programme (1 year) Master’s programme (2 years) Single-subject courses Total

2010 total women % 203 90 43 75 159 64 180 83 76 89 86 91 1,492 56 8 64 130 89 22 75 151 67 110 79 347 67 468 89 84 92 376 67 54 77

2011 total women % 204 89 46 74 152 61 181 84 87 88 101 93 1,523 56 0 111 90 9 81 207 70 106 76 360 66 457 85 84 95 402 66 53 53

2012 total women % 205 88 48 74 145 62 196 82 65 88 94 93 1,516 54 1 50 103 89 0 251 70 105 77 340 70 601 85 86 94 396 66 35 75

2013 total women % 213 89 48 70 158 65 205 82 38 92 111 90 1,591 54 0 110 85 0 285 68 114 78 357 67 788 85 82 94 412 65 19 79

98 22 446 22 77 295 575

98 82 88 92 75 73 79

97 24 461 21 86 337 709

98 82 88 89 81 70 78

95 22 457 20 93 311 701

98 81 88 100 88 69 81

101 21 458 20 115 281 488

100 82 91 94 84 69 80

5,524

5,413

5,490

5,603

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

TABLES

Table 4 Students, full-time equivalents (FTEs) and annual performance equivalents (APEs) Beginner’s programme Occupational therapy Audiology Biomedicine Biomedical lab. science Public health sciences Speech and language pathology Medicine Medical informatics Optometry Podiatry Psychology Radiography Physiotherapy Nursing Dental hygiene Dentistry Dental technology Continuation programme Midwifery Psychotherapy Specialist nursing Odont. prophylactics Master’s programme (1 year) Master’s programme (2 years) Single subject courses Total

2010 FTE APE 203 193 43 38 159 161 180 161 76 69 86 73 1,492 1,381 8 7 130 125 22 26 151 125 110 106 347 348 468 487 84 88 376 316 54 47 98 22 446 22 77 295 575

% 95 89 101 89 91 85 93 92 96 115 83 96 100 104 105 84 87

95 23 421 21 75 253 413

96 107 94 94 98 86 72

5,524 5,050

2011 FTE APE 204 196 46 45 152 140 181 165 87 72 101 97 1,523 1,393 0 1 111 108 9 12 207 201 106 94 360 359 457 430 84 75 66 53 52 97 24 461 21 86 337 709

101 21 435 21 66 295 545

5,815 5,351

2012 % FTE APE 96 205 193 100 48 46 92 145 128 91 196 166 82 65 69 96 94 90 91 1,516 1,402 1 2 97 103 102 132 0 1 97 251 223 89 105 100 100 340 315 94 601 521 90 86 78 396 412 99 35 41 105 88 94 100 77 88 77

95 22 457 20 93 311 701

84 18 428 14 94 293 535

92 5,885 5,307

% 94 96 89 84 105 96 93 98 89 95 93 87 91 65 117 89 83 94 69 101 94 76

2013 FTE APE 213 204 48 45 158 136 205 185 38 45 111 105 1,591 1,500 0 2 110 101 0 0 285 270 114 106 357 360 788 713 82 72 412 363 19 20 101 21 458 20 115 281 488

% 96 93 86 90 119 95 94 92 95 93 101 90 88 88 109

96 20 409 25 85 297 429

96 95 89 125 74 106 88

90 6,014 5,589

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

TABLES

Table 5 Degrees Professional qualifications Occupational therapy Audiology Midwifery Biomedical lab. science Speech and language pathology Medicine Optometry Psychology Psychotherapy Radiography Physiotherapy Nursing Specialist nursing Dental hygiene Dentistry Dental technology Total professional qualifications

2010

2011

2012

2013

67 0 70 64 2 219 44

59 14 55 41 32 260 42

10 34 112 311 362 39 65 17 1,416

15 38 91 298 403 37 67 14 1,466

60 18 56 52 4 272 29 18 14 39 107 14 419 38 70 13 1,223

52 10 56 57 30 219 31 32 21 23 108 113 378 39 70 17 1,256

4 460

0 547

1 351

0 464

0 0 19 21 0 17 0 119

0 2 19 23 1 17 10 78

0 1 26 39 0 20 4 69

15 3 27 43 4 20 7 177

8 19 36 0 3 0 0 0 0 8 14 728 2,144 1,786

3 26 40 0 3 0 0 0 0 1 3 773 2,239 1,888

14 38 35 9 9 0 0 8 7 17 7 655 1,878 1,668

3 30 51 14 7 1 3 4 11 3 4 891 2,147 1,758

General qualifications University diplomas BSc MSc (1 year) Work and health Biomedical lab. science Global health Clinical medical science Medical teaching and training Optometry Radiography Other main subjects MSc (2 years) Bioentrepreneurship Biomedicine Public health Health informatics Clinical medical science Speech and language pathology Medical teaching and learning Dentistry Psychology Toxicology Broad MSc (1 year) Total general qualifications Total qualifications awarded Total graduates

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

83â&#x20AC;&#x2021;

TABLES

Table 6 International relations 2010 Student exchange Out Total 182 Breakdown/area Europe 91 North America 39 Other countries 52 Breakdown/study programme Occupational therapy 5 Audiology 0 Midwifery 4 Biomedicine 9 Biomedical lab science 1 Public health 5 Health informatics (Master’s) 1 Speech and language pathology 0 Medicine 93 Optometry 3 Podiatry 3 Psychology 1 Radiography 3 Physiotherapy 11 Nursing and specialist nursing 22 Dental hygiene 1 Dentistry 20 Dental technology 0

2011

2012

2013

In 273

Out 169

In 304

Out 139

In 305

Out 169

In 269

197 16 60

82 46 41

215 24 65

65 31 43

225 21 59

74 41 54

194 22 53

14 1 6 41 23 18

12 0 2 22 6 2

22 1 5 43 26 17

5 0 4 12 7 5

24 0 4 50 18 13

7 0 3 6 8 9

16 0 5 45 12 12

0 99 10 0 1 1 10 32 0 13 0

0 82 1 0 2 6 11 6 4 13 0

1 113 7 0 2 4 14 25 3 17 2

0 58 2 3 4 6 8 7 17 1

2 126 3 0 4 13 29 3 14 0

2 91 0 5 3 11 11 3 10 0

1 122 0 2 2 16 18 5 13 0

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

TABLES

Table 7 Supplementary training for doctors with a degree from third country (including fee-paying students) Admission semester

autumn 2010

autumn 2011

autumn 2012

autumn 2013*

Registered Degree within set study time

20 7

20 12

20 7

18 -

Degree, total until 2013 Full-time students respective academic year

17.60

18.90

18.85

7.65

* One student who was admitted in the semester of 2013 was initially reported as a fee-paying student but later had his/her staus changed.

Supplementary training for nurses with a degree from third country Admission semester Applicants Registered Degree within set study time Degree, total until 2013 Full-time students respective academic year

autumn 2010

autumn 2011

autumn 2012

autumn 2013

26 23 15 20

28 26 19 25

33 25 19 22

29 25 -

21.85

25.45

24.43

10.63

Supplementary training for dentist with a degree from third country Admission semester Applicants Registered Degree within set study time Degree, total until 2013 Full-time students respective academic year

autumn 2010 48 16 10 13

autumn 2011 60 16 13 16

autumn 2012 46 16 12 15

autumn 2013 59 14 -

15.80

15.45

16.56

5.95

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

TABLES

Table 8 Revenue 2013, largest sources of funding, SEK million

Largest sources of funding Research councils Swedish Research Council FAS Formas Other government agencies Royal Institute of Technology Swedish Government Agency for Innovation Systems The Legal, Financial and Administrative Services Agency National Board of Health and Welfare Swedish International Development Cooperation Agency Stockholm university Sweden National Institute of Public Health Swedish Social Insurance Agency Swedish Armed Forces Swedish Institute for Infectious Disease Control Organisations and foundations The Cancer Fund Wallenberg Foundations The Swedish Foundation for Strategic Research The Persson Family Foundation The Heart and Lung Foundation The T & R Söderberg Foundation Children’s Cancer Foundation Karolinska Institutet Foundations The Gustav and Tyra Svensson Foundation The Swedish Society of Medicine

County & municipal councils 677.7 102.5 20.1 90.3 61.3 40.7 31.9 23.0 17.9 12.7 12.7 12.2 11.8

155.1 129.1 75.2 65.2 56.3 44.8 42.8 39.6 22.0 11.8

Stockholm County Council

Companies AstraZeneca AFA Insurance Hoffman-La Roche Novo Nordisk Scandinavia AB Pfizer KI Science Park AB MEDA AB Biogen Idec Sweden AB Biolipox AB Centocor Biotech Inc Foreign organisations and foundations European Union (EU) CHDI Foundation Org. for economic corp. and dev. (OECD) Novo Nordic Fund National Institutes of Health (NIH) H M Rausing Charitable Trust The Stanley Med. Research Inst. Jochniq Foundation Aarhus University Hospital Embassy, Kingdom of Saudi Arabia

397.1

50.8 42.2 20.0 11.1 8.8 8.4 6.1 4.7 4.4 4.4

194.3 13.1 12.6 11.9 11.4 9.3 8.6 7.9 7.7 4.2

KAROLINSKA INSTITUTET ANNUAL REPORT 2013

Karolinska Institutet Annual Report 2013 Print by E-print ISBN: 978-91-85681-60-0

Karolinska Institutet Annual Report 2013 This publication is an abridged version of the document delivered to the Swedish Government in February, 2013 Compiled by: The University Administrative Department, Karolinska Institutet Published by: The Information and Public Relations Office Karolinska Institutet 171 77 Stockholm ki.se