KAROLINSKA INSTITUTET 200 YEARS Jubilee Report
Karolinska Institutet is part of the international arena, a fact that has been a feature of our 200th jubilee celebrations. During 2010, our jubilee year, a series of scientific symposiums have been held in locations such as the USA, Japan and China in order to present the world-class research that is carried out at our university. The year of 2010 therefore provided an opportunity to commemorate our development through education and research, and a time for reflecting on the future and Karolinska Institutet’s role within the international scientific community. The past, the present and the future – we are all part of this chain. Our present has been someone else’s future, and will also be the next generation’s past. Having a feel for our history is therefore of great importance. The aim of this Jubilee Report is thus to create a record for posterity of how Karolinska Institutet celebrated its bicentenary. With words and pictures, we have documented activities and events in 2010 that in various ways have reminded us of our history and highlighted our successful research and education. We all have good reason to begin the next hundred years with a strong sense of self-confidence and great faith in the future. I am convinced that Karolinska Institutet’s future is at least as bright as its present and its past.
Harriet Wallberg-Henriksson President of Karolinska Institutet
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Not just research and education. Not just science. Karolinska Institutet’s 200th jubilee was also a time for dazzling celebrations, as seen here in the famous Golden Hall at Stockholm City Hall, where the dancing continued long into the night at the gala jubilee celebrations on 27 August.
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Harriet Wallberg-Henriksson, President..........3
Medical illustrative art exhibition......................... 17
Breakthroughs for Life.................................................................... 26
From king to king...........................................................................................7
Events outside Sweden................................................................ 18
The Junior Medicine Prize 2010.............................. 29
Scientific meetings.......................................................................................8
Jubilee promotional products...................................... 22
Jubilee gala and afterparty................................................... 30
Jubilee medals................................................................................................. 14
Wild Kids..................................................................................................................... 22
Lucia ball..................................................................................................................... 32
Commemorative stamps......................................................... 16
The jubilee book........................................................................................ 22
Students’ inspiration day.......................................................... 32
Science lectures on TV................................................................. 16
Jubilee book series................................................................................ 23
Jan Andersson, Vice President...................................... 33
Book donation............................................................................................... 16
Karolinska Institutet’s three Deans......................... 24
Towards the future................................................................................. 34
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On 11 January 2010 at 11 AM, the 200th jubilee year was inaugurated by Karolinska Institutet’s President, Professor Harriet Wallberg-Henriksson. To symbolise the jubilee, a glass sculpture was unveiled depicting the birth of a red blood cell by artist Kjell Engman at Orrefors Kosta Boda, after an image by master photographer Lennart Nilsson, who is shown here unveiling the sculpture.
From king to king On 13 December 1810, King Karl XIII of Sweden signed a letter establishing an “academy for the training of skilled army surgeons” – today’s Karolinska Institutet. The reason for this was that, during the early 19th century, more soldiers were dying in field hospitals than in battle. Naturally, this state of affairs could not be allowed to continue; Sweden’s healthcare needed to be improved and overhauled. But neither King Karl XIII nor the scientists and physicians who took on the task in 1810 of training skilled army surgeons could imagine that, 200 years later, Karolinska Institutet would be one of the world’s leading medical universities, providing education within most fields of medicine and carrying out world-class research. Many prominent scientists, such as Jöns Jacob Berzelius, Nanna Svartz, Hugo
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Theorell, Ragnar Granit, Ulf von Euler, Sune Bergström and Bengt Samuelsson, have made significant contributions to the university’s success, as did Alfred Nobel, who in 1895 stipulated in his will that Karolinska Institutet should select the recipient of the Nobel Prize in Physiology or Medicine. This role has been of great importance to Karolinska Institutet in its contacts with the international scientific community. Today, Carl XVI Gustaf is King of Sweden. In his capacity as Supreme Patron of the 200th jubilee, he contributed to our jubilee year in a variety of ways. In his speech at the jubilee banquet held at Stockholm City Hall on 27 August 2010, he emphasised that “the establishment of Karolinska Institutet was an extremely wise royal decision”.
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A SELECTION OF SCIENTIFIC MEETINGS THAT WERE ARRANGED DURING THE YEAR
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O CTOBER
Scientific symposium in tumour biology, dedicated to the memory of Hilding Bergstrand
Nobel symposium: The enlightened brain – evolution and development of the human brain (Read more on page 12)
Sino and Karolinska Institutet medical symposium
F E B RUA RY The Gunnar Birke symposium 2010: The acute inflammation – new concepts for old cells Workshop: Writing and publishing in medical education
M A RCH Equitable care – is it possible? Are all treated equally, or do factors such as sex, ethnicity and sexual orientation make a difference?
2nd International Conference on Motivational Interviewing (ICMI) 2010 Nobel conference: Medicine in developing countries – combating malaria (Read more on page 10) Physical activity in the oldest old Disease, development and stem cell of the pancreas – European Molecular Biology Organisation (EMBO) Nobel symposium: Genetics in medicine (Read more on page 12) European Pancreatic Club (EPC) the 42nd meeting
e-epidemiology: Adapting epidemiological methods for the 21st century Open lectures at Karolinska Institutet, Campus Huddinge International symposium on climate change and health NU2010 – dialogue for learning Nordic vaccine meeting 16th meeting of European Network of Occupational Therapy in Higher Education (ENOTHE) Discover for global good (Read more on page 10)
From field surgeon training to medical university – Karolinska Institutet’s education in transition
International symposium on fixational eye movements and visual stabilization
Hereditary hearing impairment and therapeutic strategies
Advances in Neuroblastoma Research (ANR) 2010 conference
What is life? The future of biology – is death changing?
Lamark Reux: Prions, Hsp90 and the inheritance of environments acquired traits
Lunch seminar – complementary integrative care
State of the art biostatistics in medical research
11th international conference on cochlear implants and other implantable auditory technologies
International minisymposium on nanotoxicology: Understanding interactions of engineered nanomaterials with biological systems
APRIL Nobel conference: Regenerative medicine (Read more on page 12) The 12th educational conference at Karolinska Institutet, 2010: Students of tomorrow – owners or participants? Energy poverty harms human health – make access to modern energy a millennium development goal
M AY Hospitals as key centres of clinical research and education (Read more on page 11) Days of molecular medicine 2010: Systems biology approach to cancer and diabetes Nobel symposium: The cell cycle and apoptosis in disease (Read more on page 12)
National and international symposium in gender medicine What’s the future of cancer epidemiology Common sense or medical ethics?
J U LY Socio-cultural and economic factors in obesity prevention, precongress meeting; European Association for the Study of Obesity (EASO) and Karolinska Institutet
N OVE MBER Frontiers in biomedical medicine: regenerative medicine
11th International Congress on Obesity, (ICO); EASO and Karolinska Institutet
Symposium on medical education: Promoting life-long learning (Read more on page 11)
AU GUST
The Gunnar Birke symposium: 35 years in obesity research – progress or back to square one?
Annual meeting of internal auditors at universities and university colleges in the Nordic region
S E PTEM BER KI 200 years, architecture and academic ambience
Implementation research symposium 2010: How to transfer public health research into practice 2nd symposium on mast cells in health and diseases European Competence Network in Mastosytosis (ECNM) annual meeting
Integrative medicine: Placebo effects and the patient-provider relationship
Zero vision for suicide, one year on – what has happened and what is happening? World Suicide Prevention Day, 10 September
Department of Microbiology, Tumor and Cell Biology celebrating KI 200 years
What is life? Cancer metabolism – back to the future
The 7th Axel Key symposium: Molecular basis of applied biological therapeutics
Media’s effects on infant development – what parents need to know
Nobel minisymposium no 48 in the series Frontiers in medicine: Caffeine and health
Traumatic injury to the central nervous system (CNS)
D EC EMBER
Harvard University and Karolinska Institutet jubilee symposium: Controversies in diet and health
46th Annual Meeting of the European Association for the Study of Diabetes (EASD)
Skin allergies – why are some increasing while others decrease?
Scandinavian Society for Antimicrobial Chemotherapy’s (SSAC) yearly conference
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Symposium
Nobel conference
Discover for global good
Medicine in developing countries – combating malaria
Science is all about making discoveries. Today’s medical scientist works to make discoveries at the level of the cell, tissue, organism or population. New knowledge may translate into drugs, diagnostic tests, vaccines or preventive measures and systems to improve the lives of patients and populations. In recent years, Karolinska Institutet has invested extensively in advanced research facilities. The new Karolinska Institutet Science Park is expected to bring new opportunities for making discoveries. On 19 October, Karolinska International Research and Training Committee (KIRT), arranged a seminar with the aim of exploring possible links between basic sciences and health problems of a global nature. The invited guests included highly respected speakers such as Professor Ajit Varki from the University of California, San Diego, Dr Chris Wilson from the Bill and Melinda Gates Foundation, and Dr Christopher Elias from Program for Appropriate Technology in Health (PATH). Professor Varki asked “Are there answers to the global good in molecular research?” and replied to his own question by showing examples within the field of glycobiology. The symposium was attended by more than 300 participants.
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On 10–11 June, Professor Mats Wahlgren from Karolinska Institutet and Dr Louis H. Miller from National Institutes of Health (NIH), Bethesda, USA, arranged a Nobel conference at Karolinska Institutet to discuss new scientific understanding of the malaria-causing parasite Plasmodium falciparum. This parasite struck nomadic peoples when they formed settled communities 100,000 years ago. The meeting discussed how Plasmodium falciparum – which today dominates both the number of cases and the severity of malaria – has succeeded in gaining an advantage in terms of survival by constantly changing its surface proteins, and its constant modification of the gene expression internally. Around one hundred researchers participated and discussed findings at the very cutting edge of research, which were presented by 42 speakers from the world’s most prominent universities. The talks covered genetics, epigenetics and regulation of the genes that control the incidence of severe malaria, cell biology, immunology, animal models and new forms of treatment that may reduce the death rate from the disease. Malaria parasites cause approximately 250 million clinical cases and around 1 million deaths each year.
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a selection of scientific meetings 1. Professor Bertil Fredholm is being interviewed at the Nobel minisymposium: Caffeine and health.
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2. Professor Harriet Wallberg-Henriksson at the Implementation research symposium 2010: How to transfer public health research into practice. 3. A scientific symposium in tumour biology was arranged to the memory of Hilding Bergstrand, a former Professor in pathology. 4. Many people attended the 2nd symposium on mast cells in health and diseases. 5. Professors Karin Schenk-Gustafsson and Anders Ekbom at the National and international symposium in gender medicine.
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6. Professor Martin Ingvar at the symposium Integrative medicine: Placebo effects and the patient-provider relationship.
S ymposium
Symposium
Promoting life-long learning
Hospitals as key centres of clinical research and education
In connection with the presentation of the 2010 Karolinska Institutet Prize for Research in Medical Education in early November, the Board of Higher Education arranged a symposium in association with the Gunnar Höglund and Anna-Stina Malmborg Foundation. The theme was “State of the art lectures”, and the 2010 winners and previous winners gave lectures and took part in workshops and discussions on medical education. Professor Henk Schmidt from Rotterdam described the way in which perception of how we learn has changed, and how fallacies remain, for example with regard to the value of lectures. One of the 2010 year’s two winners, Professor Richard Reznick from Toronto, explained that even simple models can be used for simulation when teaching surgical methods. Professor David M. Irby from San Francisco, the other winner of 2010, described how self-evaluation can be used to improve life-long learning, while Professor Geoffrey Norman from Ontario emphasised the importance of evaluating clinical experience in his lecture on examination and evaluation.
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In association with the European Health Property Network (EuHPN), Locum AB – owner of the new university hospital building in Solna – arranged a symposium on the hospital of the future on 5 May. How can such a hospital best be designed in order to treat and care for patients, while at the same time acting as a centre for education and research? Cooperation between the healthcare system and medical universities poses unresolved challenges – as well as new opportunities. The situation in Germany and the Netherlands was reviewed by invited speakers, followed by an analysis of the situation in Sweden by Professor Martin Ingvar, Dean of Research, and Professor Bo Angelin, both from Karolinska Institutet. Professor Lennart Persson, Managing Director, presented his visions for the future. The symposium attracted a European audience of well over two hundred.
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N obel conference
Nobel symposium
Regenerative medicine
The cell cycle and apoptosis in disease
The Nobel conference “Regenerative Medicine”, arranged by Karolinska Institutet’s Professor Urban Lendahl, was held at Karolinska Institutet on 14–16 April 2010. The conference covered the rapidly emerging area of regenerative medicine, a research field which includes the use of stem cells to replace ailing or injured tissue as well as the activation of patient-endogenous stem cell populations. The conference succeeded in covering a broad range of organ systems, such as blood and nervous systems, pancreas, skin and eye, spanning basic research to clinic research. The Nobel Laureate Sir Martin J. Evans gave a historic perspective on embryonic stem cells, and was joined by a panel of 25 leading international experts, who provided an excellent update of the field, with a large set of unpublished data.
N obel symposium
The enlightened brain – evolution and development in the human brain
Cell division and cell death are the two predominant physiological processes that regulate tissue homeostasis in the adult organism. The importance of dysregulation of these processes in the pathogenesis of major diseases, such as cancer, myocardial infarction, stroke, atherosclerosis, infection, inflammation and neurodegenerative disorders, is becoming increasingly evident. Hence, attempts to find modulators of the cell cycle and cell death programmes are being made with the hope of creating novel therapeutic approaches to the treatment of these diseases. It is clear that improved understanding of how cells balance life-and-death processes is crucial for this development. In view of this, a Nobel symposium entitled “The cell cycle and apoptosis in disease” was arranged by Professor Boris Zhivotovsky at Karolinska Institutet on 23–26 May. More than 100 participants from all over the world – including three Nobel Laureates: Sir Tim Hunt, Robert H. Horvitz and Aaron Ciechanover – attended the meeting and were involved in interesting discussion.
Nobel symposium At the beginning of June, a three-day Nobel symposium entitled “The enlightened brain” was held on various aspects of the development of the brain. The name was inspired by the fact that Karolinska Institutet was founded on the scientific ideas that arose during the Age of Enlightenment, and that the symposium addressed unique aspects of human consciousness and the social brain. Around thirty leading researchers from around the world lectured about and discussed subjects such as evolution and theory of consciousness, mirror neurons, the emotional brain and neuroeconomics. In view of the fascinating subject field, the symposium’s organisers – Professors Hans Forsberg and Hugo Lagercrantz from Karolinska Institutet – also arranged an afternoon of open lectures, at which four internationally recognised researchers – Professors Giacomo Rizzolatti from Parma, Semir Zeki from London, Morten Kringelbach from Oxford and Peter Gärdefors from Lund – explained various aspects of the development of the cultural brain to students and the general public.
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Genetics in medicine The Nobel symposium “Genetics in medicine” was held on 15–18 June, and was arranged by Professors Magnus Nordenskjöld, Juha Kere, Catharina Larsson, Urban Lendahl and Anders Zetterberg from Karolinska Institutet. A total of 36 talks addressed various aspects of the explosive growth experienced by medical genetics in recent years, and well as the breadth of the subject and its significance in terms of various areas of medical research. The talks dealt with new genetic mechanisms for basic physiological functions, mankind’s evolutionary history mapped on genetic paths, and a number of examples of how it has been possible to map genetic mechanisms behind various diseases. The symposium provided many examples of the significance of genetics in modern biomedical research, and highlighted the front line of research within key medical areas. The speakers included four Nobel Laureates: Elizabeth H. Blackburn, Thomas R. Cech, Joseph L. Goldstein and Harold E. Varmus.
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Nearly 30,000 scientists, teachers and students from all over the world participated in the scientific meetings arranged by Karolinska Institutet during the bicentenary. KI 200 years scientific meetings during the bicentenary – 60 in total
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Scientific symposium, main organiser Karolinska Institutet 3 1
Scientific symposium, co-organiser Karolinska Institutet Symposium on education, main organiser Karolinska Institutet
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Symposium on education, co-organiser Karolinska Institutet Nobel conference/symposium Nobel conference/symposium Other symposium, main organiser Karolinska Institutet
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The number of participants varied widely – from fewer than 100 at the smaller meetings to nearly 17,000 at the four-day 46th Annual Meeting of the European Association for the Study of Diabetes, EASD. Most meetings were attended by between 100 and 400 participants.
Highlights of the scientific meetings according to an internal survey
Language of the scientific meetings
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Good lecturers High-class scientific meeting International context
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Other symposium, co-organiser Karolinska Institutet
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Swedish
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Jubilee medals On account of its 200th jubilee, Karolinska Institutet produced medals in three different classes: gold, grand silver and silver. From 2010 and onwards, these medals can be honored to people who have made outstanding, excellent or distinguished efforts respectively for Karolinska Institutet. Employees and those with emeritus status at Karolinska Institutet have the right to submit proposals. Twenty-four medals were awarded in 2010, of which six were gold. H.M. King Carl XVI Gustaf received the first gold
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medal at a ceremony held at the Royal Palace of Stockholm on 14 April. He then awarded four more gold medals himself at the gala jubilee celebrations on 27 August at Stockholm City Hall. The sixth gold medal was awarded to Professor Paul Greengard at Karolinska Institutet’s jubilee banquet at the residence of the Swedish ambassador in Washington on 23 September. The silver medals were awarded in the autumn of 2010 during academic ceremonies at Karolinska Institutet.
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G O L D MEDAL
H.M. King Carl XVI Gustaf. His Majesty was recognised for his role as Supreme Patron of Karolinska Institutet’s 200th jubilee, and for his great interest in Karolinska Institutet’s operations.
Paul Greengard. Professor and Nobel Laureate in 2000, was recognised for the increasing understanding of neurological and mental illnesses, and for his cooperation with Karolinska Institutet spanning more than 40 years.
Ingvar Carlsson. Former Swedish Prime Minister, was recognised for his significant involvement in both national research issues and research projects of great importance to Karolinska Institutet.
Bengt Samuelsson. Professor, Nobel Laureate in 1982 and Karolinska Institutet’s President 1983–95, was recognised for his pioneering research efforts and his insightful leadership of Karolinska Institutet.
Marcus Storch. Director and Chairman of the Nobel Foundation, was recognised for his many years of firm commitment to Swedish medical research and his extremely valuable work for Karolinska Institutet.
Hans Wigzell. Professor and Karolinska Institutet’s President 1995–2003, was recognised for his outstanding work for Swedish medical research and his skilful and visionary leadership of Karolinska Institutet.
G RA N D SILVER MEDAL Margareta Almling, Administrative Director and Higher Education Director 1964–86, Karolinska Institutet Margareta Blombäck, Professor Emerita, Karolinska Institutet Kerstin Hagenfeldt, Professor Emerita, Karolinska Institutet Ulf Hjertonsson, Ambassador, former Swedish Consul General in New York Gunnar Höglund, Professor Emeritus, Karolinska Institutet Eva Klein, Professor Emerita, Karolinska Institutet Georg Klein, Professor Emeritus, Karolinska Institutet Sten Linder-Aronson, Professor Emeritus, Dean of the Faculty of Dental Medicine 1987–93, Karolinska Institutet
SILVER MEDAL Jan Lindsten, Professor Emeritus, Dean of the Faculty of Medicine 1996–98, Karolinska Institutet Anna-Stina Malmborg, Docent, Karolinska Institutet Erling Norrby, Professor Emeritus, Dean of the Faculty of Medicine 1990–96, Karolinska Institutet Sten Orrenius, Professor Emeritus, Dean of the Faculty of Medicine 1983–90, Karolinska Institutet Nelson Sewankambo, Professor and Principal at Makerere University College of Health Sciences, Uganda Göran Stiernstedt, former Deputy Director of Stockholm County Council Yi-Xin Zeng, Professor and Director of the Cancer Center at Sun Yat-sen University, China
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Tomas Cronholm, Professor Emeritus, Karolinska Institutet Staffan Cullheim, Professor, Karolinska Institutet Marja Lind Tuomela, Cashier, Jöns Jacob restaurant, Karolinska Institutet Ester Mogensen, PhD and University Lecturer, Karolinska Institutet Per Olsson, Librarian, former Head of the Karolinska Institutet University Library Birger Winbladh, Professor Emeritus, Karolinska Institutet
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Commemorative stamps unveiled In May 2010 the Swedish post office, Posten, honoured Karolinska Institutet’s bicentenary with two commemorative stamps. The stamps depict the basic elements silicon and selenium, which were discovered by Jöns Jacob Berzelius, one of the founders of Karolinska Institutet, nearly 200 years ago. The engraved plates were created by Piotr Naszarowski, a well-known artist and master engraver who has been responsible for hundreds of stamps in Sweden, Poland, the Vatican City, the USA and Japan. The photographs were taken by Professor Lennart Nilsson, world-famous pioneer in medical photography.
Popular science lectures on TV During the jubilee year, popular science lectures given by prominent researchers at Karolinska Institutet were broadcast nationwide on the television programme UR Samtiden. The TV channel UR produces educational and factual programmes for the general public. These lectures dealt with topical subjects such as the effect of the outdoor environment on children’s health, why certain people experience serious side effects from medication, the degree to which lifestyle can change our health, why levels of long-term sickness absence are lower in certain workplaces, and periodontitis – the world’s most common form of infection. Other subjects included modern radiology, the mysteries of cancer, pain, child allergies, the brain of the child, premature birth, physical activity, and how Karolinska Institutet’s biobank is used in research. 16
Valuable book collection donated to Karolinska Institutet To celebrate the university’s bicentenary, AstraZeneca donated a valuable book collection to the Hagströmer Library at Karolinska Institutet. The “Berzelius Collection” consists of more than 3,000 works by Swedish greats within the fields of pharmacy, chemistry and medicine. Among the most valuable books are rare first editions from the 18th and 19th centuries, including Carl Wilhelm Scheele’s only book, Luft und Feuer (1777), in which he published his important discovery of oxygen. The donation has enriched the library’s already impressive collection of historical medical books.
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Medical illustrative art exhibition During the late spring and summer of 2010, an extraordinary exhibition of medical illustrative art was held at the Prince Eugen’s Waldemarsudde museum in Stockholm. The exhibition “ARS MEDICA – The Art of Medical Illustration from the Middle Age to Lennart Nilsson” comprised the finest and most fascinating books and pictures found in the treasuries of the Hagströmer Library, one of the world’s leading collections of historical medical books, illustrations and early photographs. At the well-attended exhibition, the public was given a rare opportunity to admire some of the library’s extensive collections, which contain more than 35,000 books and volumes of prints from the 15th century to the present. The two storeys and twelve rooms of the exhibition showed hand-coloured woodcuts in 16th century herbals, 17th century anatomical atlases with copperplate engravings,
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microscope books from the 1700s showing the first images of objects too small to be seen with the naked eye, and the most famous books and print collections in the history of obstetrics. The illustrations also reflected centuries of human fascination with the anomalous. Here, the most famous bestiaries from the 1500s and 1600s and 19th century lithographs of skin diseases, tattoos and the anatomy of the eye were subject of the visitors’ fascination. There was also a separate section dedicated to the history of medical photography, with original photographs of injured soldiers from the American Civil War, Darwin’s studies of how humans and animals express emotions and the very first X-rays from 1896.
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A SELECTION OF EVENTS HELD OUTSIDE SWEDEN DURING THE JUBILEE YEAR
Drs Michael J Fox and Clara Hellner Gumpert.
World Expo 2010 in Shanghai.
N EW YORK
PEKING & SHANGHAI
On 5 March, Karolinska Institutet’s Dean of Doctoral Education Clara Hellner Gumpert and Vice President Jan Andersson visited New York. Here, the title of Honorary Doctor at Karolinska Institutet was conferred on the actor Michael J Fox at a special ceremony. In 2000, he founded the Michael J Fox Foundation for Parkinson’s Research, which is now the world’s largest private organisation for research into Parkinson’s disease. To date, the foundation has awarded more than USD 170 million to research projects around the world, including to researchers at Karolinska Institutet. The foundation’s motto is “We don’t just fund research. We fund results.” Fox, who himself was diagnosed with Parkinson’s disease in 1991, hopes that the foundation will encourage research that shortens the distance between ideas and application – in other words, getting innovation and industry to work more closely together. “Strongly influenced by Dr Fox’s personal philosophy, his foundation operates with rare dynamism and a constant focus,” said Associate Professor Gumpert. In his speech of thanks, Fox expressed his gratitude to Karolinska Institutet and highlighted the significance of his foundation and Karolinska Institutet sharing a belief in creating a better future.
On 21–23 May, representatives from Karolinska Institutet, as the only university, took part in a major Swedish trade delegation to China to celebrate 60 years of diplomatic relations between Sweden and China. The delegation, which was led by H.M. King Carl XVI Gustaf and Deputy Prime Minister Maud Olofsson, consisted of leading representatives of Sweden and Swedish industry. Karolinska Institutet’s President Harriet WallbergHenriksson took part in a symposium in Peking where she spoke about Karolinska Institutet’s innovation system which has received worldwide recognition. The system enables Karolinska Institutet’s researchers to obtain expert assistance from within the university to evaluate and commercialise their discoveries and inventions. Issues relating to intellectual property rights were also a key item on the agenda at the concluding symposium held at the World Expo 2010 in Shanghai, and there was a great deal of interest in Karolinska Institutet’s innovation system from representatives of the Chinese research community.
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Professor Paul Greengard.
Students at Sweden Days.
WA S H I N G TON D C
SINGAPORE
On 23 September, Karolinska Institutet’s bicentenary was celebrated in Washington DC with a scientific symposium at the House of Sweden, arranged in association with the National Institutes of Health (NIH). The theme was public health and aging, attracting many representatives from American universities and research institutes as well as politicians. The USA is Karolinska Institutet’s single most significant partner nation, and the majority of Karolinska Institutet’s management were present. Jack W. Szostak, Nobel Laureate, gave a key note lecture about his research into the origins of life. Moreover, the internationally renowned NIH researchers Luigi Ferrucci and Susan Resnick described their studies of aging. Several of Karolinska Institutet’s researchers took part. Professors Henrik Grönberg and Nancy Pedersen explained about the Swedish twins register, and about LifeGene, a national study that is set to have a major global impact. Professors Torkel Klingberg and Laura Fratiglioni talked about the brain, how it can be repaired and how this is affected by aging. Professor Hans Jörnvall spoke about the Nobel Prize in Physiology or Medicine. The day concluded with a jubilee banquet at the residence of the Swedish ambassador Jonas Hafström, at which Paul Greengard, Nobel Laureate, was awarded Karolinska Institutet’s gold medal for his research, and for more than 40 years of collaboration with researchers at Karolinska Institutet.
Karolinska Institutet has long had a number of important partners in Singapore. On 12–13 October, Karolinska Institutet’s jubilee was celebrated in Singapore as part of Sweden Days, an annual event at two of Karolinska Institutet’s partner universities, the National University of Singapore (NUS) and Nanyang Technological University (NTU). Karolinska Institutet’s management was on site, and two of Karolinska Institutet’s professors gave talks to students and other invitees. Professor Martin Ingvar spoke about “Human pain as a biomedical entity”, and Professor Arne Ljungqvist, also a member of the International Olympic Committee, talked about “The Olympic spirit and doping – incompatible phenomena”. Sweden Days are primarily an event for students on undergraduate and graduate level. Karolinska Institutet has highly active student and PhD student exchange programmes with both NUS and NTU, and the doctoral students presented their research. On the evening of 12 October, the Swedish ambassador Ingemar Dolfe held a reception at his residence, where Karolinska Institutet was congratulated on 200 years of successful research and education by representatives from Singapore’s academic and medical communities.
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Professor Martin Ingvar.
Professors Laura Esserman, Harriet Wallberg-Henriksson and Per Hall.
TO K YO
SAN FRANCISCO
In October, it was time for Tokyo to take part in Karolinska Institutet’s 200th jubilee celebrations. A visit was arranged in association with the Swedish embassy, the Swedish Agency for Growth Policy Analysis and Invest Sweden. The programme began on 15 October with a visit to the University of Tokyo and a meeting with RIKEN, followed by lunch at the residence of the Swedish ambassador, Stefan Noreén. In the afternoon, the photographic exhibition “Karolinska Institutet 200 Years – Celebration of Knowledge and Health” was inagurated, at the Swedish embassy by Karolinska Institutet’s President Harriet Wallberg-Henriksson. The same exhibition had previously been staged at the House of Sweden in Washington DC. A scientific symposium was then held in partnership with the embassy and the Brain Science Institute at RIKEN. Researchers Martin Ingvar, Agneta Richter Dahlfors, Tomas Hökfelt, Fredrik Ullén and Clara Hellner Gumpert, all from Karolinska Institutet, spoke about “Unravelling Mysteries of the Brain” together with brain researcher Professor Katsuhiko Mikoshiba from RIKEN Brain Science Institute, who is also a visiting professor at Karolinska Institutet. On 16 October, the scientific journal Nature hosted a popular Science Café at the Swedish embassy, at which lectures were given and answered questions on the subject of “The Smart Brain at Work”. Nature’s subscribers were invited, and there was a huge amount of interest.
On 27–28 October, 15 researchers from Karolinska Institutet travelled to San Francisco for a workshop on breast cancer together with researchers from the University of California San Francisco (UCSF). The workshop was initiated by Susan Desmond Hellman, Chancellor of UCSF, and Karolinska Institutet’s President Harriet Wallberg-Henriksson, in collaboration with Sweden’s Consul General in San Francisco, Barbara Osher, who chairs the Osher Foundation, a major donor to Karolinska Institutet. The workshop, which was led by Professors Laura Esserman, Laura van’t Veer and Britt-Marie Ljung from UCSF and Per Hall and Jonas Bergh from Karolinska Institutet, was a great success. A number of interesting points of contact within various projects were identified, and follow-up meetings were immediately arranged for the various joint projects relating to breast cancer. One key reason for the meeting in San Francisco was that during its 200th jubilee year, Karolinska Institutet received a large donation from husband and wife Märit and Hans Rausing for a research project with the aim of reducing the number of cases of breast cancer by 40–50 percent (read more on page 28).
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Jubilee promotional products Prior to the bicentenary, Karolinska Institutet employees were invited to enter a competition by suggesting new promotional products for the 200th anniversary range. Judged to be “useful”, with the potential to “promote health” and “prevent injury”, the winning product turned out to be a bicycle helmet approved by EU standards for biking, skateboarding and rollerblading, and developed in collaboration with two of Karolinska Institutet’s researchers, Drs Per Hamid Ghatan and Claes Hultling. Other jubilee products included a Rubik’s cube featuring images by photographer Lennart Nilsson, a rucksack, a wine glass and carafe and a serving tray.
Lansering av frimärke
One of the 6,000 students at Karolinska Institutet proudly displays a photograph of himself in the jubilee book.
The jubilee book: A year at Karolinska Institutet
For several years, Wild Kids has been Sweden’s most popular TV series for children up to the age of 15. The programme features two teams of five youngsters who live in a wilderness environment and compete against each other to see who can survive best in the wild using simple tools. In spring 2009 and 2010, Karolinska Institutet teamed up with the series to produce a special book about preventing, avoiding and dealing with injuries and illnesses that can occur in the countryside. The book was written by Maaret Castrén, Professor of Emergency Medicine at Karolinska Institutet. The idea behind Karolinska Institutet’s involvement in Wild Kids was to provide an interesting way of encouraging children – the students of the future – to take an interest in medical issues.
Over the course of a year, documentary photographers Erik G Svensson and Marcus Erixson captured many of the settings, people and events that are unique to Karolinska Institutet on camera. During their photographic explorations they have followed students, researchers, administrators and many others that together propel Karolinska Institutet forward. The result is the jubilee book “A year at Karolinska Institutet”, which includes a variety of subjects: from students in deep concentration in an operating theatre and scientists carrying out cutting-edge research in their laboratories, to board meetings, graduation ceremonies, sports events and the official inauguration of the bicentenary. With more than 250 photographs, “A year at Karolinska Institutet” offers fantastic evidence of the diversity and true nature of the university. Each photograph is accompanied by a short, informative and interesting caption that gives the reader a better understanding of Karolinska Institutet’s broad organisation and how its people are contributing to the achievement of the mission to improve human health. The book is accompanied by “200 years at Karolinska Institutet”, a historical account of the university’s first 200 years. The booklet was written by Professor Emeritus Jan Lindsten, Dr Olof Ljungström and Dr Daniel Normark. The jubilee book was given to all employees, students and associates as a memento of the bicentenary.
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Wild Kids
Jubilee book series To celebrate the bicentenary, a series of books covering various aspects of the university’s rich and exciting history was published during 2010. The book series include an interesting presentation of Karolinska Institutet’s 114 most important scientific contributions during the last 200 years. Portraits of Karolinska Institutet’s presidents: the collection*, Anna-Stina Malmborg n Forging a medical university The establishment of Sweden’s Karolinska Institutet, Julius Rocca n How medicine became science Two centuries of Karolinska Institutet*, Karin Johannisson, Ingemar Nilsson and Roger Qvarsell (Eds.) n Breaking subject boundaries Karolinska Institutet and the Rockefeller Foundation 1930–1945*, Olof Ljungström n Carl Johan Ekströmer*, Bengt Pernow n THE MEDICAL ARTS, ARS MEDICA Catalogue in Swedish & English, Hagströmerbiblioteket n “Sterile sweat” Some characters and events from Karolinska Institutet’s history*, Hans Wigzell (Ed.) n Student life*, Wilhelm Engström n Strategies Education at Karolinska Institutet 1960–2010*, Kerstin Hagenfeldt (Ed.) n
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The age of two faculties Education at Karolinska Institutet 1960–2010*, Kerstin Hagenfeldt (Ed.) n The medical university Education at Karolinska Institutet 1960–2010*, Kerstin Hagenfeldt (Ed.) n Huddinge Hospital 1972–2002*, Anders Persson and Folke Sjöqvist (Eds.) n The architecture and academic ambience of Karolinska Institutet Competition/establishment/renewal*, Anders Bergström, Lars Marcus and Daniel Koch n Progress in Neurobiology Chemical signaling in the nervous system in health and disease: Nils-Åke Hillarp’s legacy, Ann-Charlotte Granholm, Marianne Schultzberg and Lana Skirboll n 114 Important Scientific Contributions from Karolinska Institutet, Jan Lindsten, Ove Hagelin, Tomas Jansson och Gertie Johansson n Gammelgården The story of Karolinska Institutet’s oldest building*, Eva-Lotta Erlingsson n Theses at KI, 1810–1874 An entry ticket to a permanent academic career system*, Jan Lindsten, Ove Hagelin, Tomas Jansson and Gertie Johansson n
*This book is only available in Swedish.
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It was a fantastic year with many highlights, and the importance of education was emphasised in many different ways.” Sari Ponzer, Dean of the Board of Higher Education
Externally, the rest of the world has confirmed that what we have done and what we want to do really are meaningful.” Martin Ingvar, Dean of the Board of Research
The focus for the future is to ensure that PhD studies become even more stimulating and challenging.” Clara Hellner Gumpert, Dean of the Board of Doctoral Education
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Karolinska Institutet’s three Deans were asked what the jubilee year has meant to them, and what impressions it has left for the future. “It was a fantastic year with many highlights, in which all Karolinska Institutet’s operations were illuminated and the importance of education was emphasised in many different ways. In particular, I would like to single out the ‘State of the art lectures’ seminar, at which four of the world’s most prominent researchers within medical education – Professors Henk Schmidt, Richard Reznick, David Irby and Geoffrey Norman – gave lectures and discussed the
importance of good pedagogy in medical education. During the jubilee year, we were also reminded of our history. When Karolinska Institutet was founded 200 years ago, it was as a seat of learning – a school for army surgeons.” “The students’ inspiration day, at which external and internal alumni talked to the students about their professional successes, was a resounding success. I would like to take things further and give students from all courses the opportunity to be inspired by popular science lectures from our expert professors.”
“The jubilee gave us the opportunity to spend a whole year showing what we have achieved during our 200 years of operations. This has been highly significant, both internally and externally. Internally, it has instilled a sense of self-esteem and pride in everyone at Karolinska Institutet. Externally, the rest of the world has confirmed through generous contributions to our fundraising campaign that what we have done and what we want to do really are meaningful. Receiving an additional billion
kronor in addition to our regular funding provides excellent opportunities for taking our research to the next level. And we’ll also be getting a new auditorium – and a real masterpiece at that.” “Our fundraising campaign, which was incredibly successful by Swedish standards, means that fundraising now occupies an important position in our internal consciousness. But if we want to reach potential donors, we must speak a language that everyone understands. This is a valuable insight – and one that is good both for us and for the rest of the world.”
“The importance of doctoral education, both for individual researchers and for Karolinska Institutet as a whole, has been illustrated in various ways during the jubilee year, not least through the twenty or so interview films in which researchers of all ages who defended their theses at Karolinska Institutet talk about their PhD studies. These films show that PhD studies at Karolinska Institutet – which for most of them were carried out during their twenties and thirties – have been of decisive importance in terms of their
continued careers and from a purely personal point of view, too. After all, this is when we develop as people and are particularly receptive to new ideas.” “When focusing on our history, we see that the knowledge and values we give to our PhD students will have a great impact on the future, and on their ability to deal with the medical problems of tomorrow. What we do today will become part of history: it’s the PhD students of today who will lead developments within research and education onwards. The focus for the future is to ensure that PhD studies become even more stimulating and challenging.”
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2010 marks the final of our Breakthroughs for life campaign
People’s health and quality of life are what drives Karolinska Institutet, something which is shared by many others. This is shown by the overwhelming support for Karolinska Institutet’s jubilee campaign, “Breakthroughs for Life”. Thanks to the great commitment and generosity of the people around us, the campaign has now reached its target as one of the most successful ever in Europe. With one billion Swedish kronor raised for research concerning the big endemics, Karolinska Institutet is well equipped to work towards achieving medical breakthroughs with the aim of reducing people’s suffering. This is the beginning of a long and exciting journey. We look forward to making it together with our donors. Princess Christina, Mrs Magnuson Chairwoman of Karolinska Institutet’s “Breakthroughs for Life” committee
Princess Christina, Mrs Magnuson presents a golden egg to Karolinska Institutet’s President Harriet Wallberg-Henriksson to symbolise the fact that “Breakthroughs for Life” has raised SEK 1 billion for research.
W e wou ld like t o t hank t h e f ollowing f o r t h ei r gene r o u s c on t r i bu t ions in c onne c t ion wi t h Ka r olinska I ns t i t u t e t ’ s 2 0 0 t h j u b ilee : AFA Insurance The Assaël Foundation AstraZeneca The Barbro Osher Pro Suecia Foundation The Bernard Osher Foundation The Bertil Hållsten Foundation The Bibbi and Nils Jensen Foundation Carl Bennet AB The Catarina and Sven Hagströmer Foundation Charles D. Zucker David Agger David E. R. Dangoor Dr Åke Olsson’s Foundation for Haematological Research The Eric K. Fernström Foundation The Einhorn Family Foundation The Erling-Persson Family Foundation The Maths O. Sundqvist family
The Peter Thelin Family Folksam and KPA Pension Fredrik Lundberg Friends of Karolinska Institutet,* USA The Gunnar Höglund and Anna-Stina Malmborg Foundation Harold and P. L. Osher The Swedish Heart-Lung Foundation Inger and Björn Savén The Jochnick Foundation John and Susan Gallo Karin Plym Forshell-Velander The Knut and Alice Wallenberg Foundation Kunskapsskolan Education The Lisa and Johan Pritzker Family Fund Lupus Clinical Trials Consortium Maria Frisk The Marianne and Marcus Wallenberg Foundation
Marie Barnevik McKeige The Mats Kleberg Foundation Meda The Michelle and Robert Friend Foundation Märit and Hans Rausing Paul Lederhausen The Sandler Foundation Skandia The Sven and Eva Pettersson Foundation Swedish Orphan Biovitrum The Sven and Dagmar Salén Foundation et consortes The Tobias Foundation The Torsten and Ragnar Söderberg Foundations The Vera and Göran Agnekil Foundation for Medical Research The Will K. Weinstein Revocable Trust The William K. Bowes, Jr. Foundation
*Friends of Karolinska Institutet is a US nonprofit corporation actively supporting Karolinska Institutet’s research.
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Examples on how “Breakthroughs for Life” donations build for the future
N ew auditorium for Karolinska Institutet
Large donation advances cancer research
As part of the “Breakthroughs for Life” campaign, the Erling-Persson Family Foundation made a substantial donation assigned for the creation of a new auditorium at Karolinska Institutet’s Solna campus. The 1,000-seat assembly hall will provide an attractive meeting place for anyone who works with the university, offering scientists, students and members of the public a place to congregate for every kind of occasion. Whether there is a lecture held by a Nobel Laureate or training for tomorrow’s healthcare professionals, people need to gather in a modern environment that meets today’s technological and educational needs. Karolinska Institutet will now be able to increase its ability to position itself, strengthen contacts and build new knowledge in both national and international research environments. The auditorium is expected to be officially inaugurated during 2013. As founder and chairperson of the Erling-Persson Family Foundation, Director Stefan Persson has shown considerable personal dedication to Karolinska Institutet and has provided sustained support for its research and development.
In 2010, Märit and Hans Rausing made a generous donation to Karolinska Institutet and the “Breakthroughs for Life” campaign in order to fund a large-scale research project on breast cancer. The aim of the project is to dramatically reduce the number of women suffering and dying from the disease. The Karma Study is one of the world’s largest breast cancer studies, and focuses on the causative factors and the early stages of the disease. The Karma Study is headed up by Professors Per Hall and Jonas Bergh, who focus their research on reducing the risk, and finding effective diagnosis and treatments. In order to take more effective preventative measures, the Karma Study concentrates on the healthy individual and the early stages of the disease. The Rausing family’s dedication to research has given Karolinska Institutet new opportunities to make a difference for the millions of women who live with, or who will suffer from, breast cancer in the future. With the Märit and Hans Rausing’s Breast Cancer Initiative, Karolinska Institutet is confident that the project will reach its goal to reduce the incidence of the disease by 40 to 50 percent.
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The Junior Medicine Prize 2010 To fire young people’s interest in medical research, Karolinska Institutet – in collaboration with the children’s magazine Kamratposten – awarded the Junior Medicine Prize in 2010. The prize was founded with the ambition of showing children aged 8 to 14 how fun and exciting science can be. During nine months of the jubilee year, children and teenagers from around Sweden were given the opportunity to interact with doctoral students and young researchers at Karolinska Institutet through a special science club on the Kamratposten website, KPwebben.se. Here, the budding scientists researched answers to medical questions in a range of scientific fields. At the end of each month, one of the participants was named “researcher of the month”, winning a place in the final for the Junior Medicine Prize. At the end of the year, the nine finalists were then given their final and probably toughest challenge thus far: to write their own research plan. On 14 December, a unanimous jury declared 12-year-old Michelle Atlas overall winner for her interesting, clever ideas for research into whether interacting with animals can have a positive effect on people with mental health problems. Since the project proved so successful, Karolinska Institutet and Kamratposten have decided to continue with the contest and the next Junior Medicine Prize will be awarded in December 2011.
The photograph shows a laboratory practical with dry ice create smoke-laden soap bubbles.
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JUBILEE GALA AND AFTER PARTY
The evening’s hosts, actors Sissela Kyle and Mikael Tornving.
Swedish rock band The Ark with singer Ola Salo.
Professor Hans Rosling showed how the population in the world has grown.
At the afterparty, people enjoyed live bands from Karolinska Institutet like Contardo.
Dancefloors, live bands and DJs at three stages.
Björn Granath from The Royal Dramatic Theatre as Jöns Jacob Berzelius.
On 18 November 2010 more than 4,000 employees, students and alumni celebrated Karolinska Institutet with a spectacular jubilee gala at the Ericsson Globe in Stockholm. The gala was held to acknowledge 200 years of remarkable history and the people who have contributed to great achievements in the field of improving human health. During the two-hour show, guests were treated by topclass entertainment including stand-up comedy, appearances by professional dancers and acrobats, and music ranging from opera singing and historical cantata to the latest pop songs. The university’s rich history was demonstrated by animated video sequences, and actor Björn Granath from The Royal Dramatic Theatre gave an excellent performance portraying one of Karolinska Institutet’s founders, Jöns Jacob Berzelius, on stage. During the evening, colleagues, partners and celebrities across the world sent their birthday wishes to Stockholm via video conferencing, which was greatly appreciated. At the afterparty, partygoers enjoyed various DJs and live bands, a karaoke bar and a concert from the Swedish rock band The Ark.
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I would never have expected a university to be able to celebrate on such a large scale!” Being a student at Karolinska Institutet is a celebration in itself, but its 200th anniversary made it all the more special.” The gala performance was a powerful mixture of historical flashbacks, circus performances, stand-up and images from everyday life at Karolinska Institutet. I realised that I am part of an historic, important and significant part of Swedish history.” Quotes about the jubilee gala, taken from blogs written by Karolinska Institutet’s students.
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Students’ inspiration day On 13 December, Karolinska Institutet’s birthday, the university’s students were invited to an inspiration day to meet, listen to and be inspired by successful alumni. These included heads of business, leaders of international organisations, government officials, leading researchers from industry and Karolinska Institutet’s own professors, all of whom spoke about their successful careers after graduating. The inspiration day proved extremely popular, and in her speech to the students President Harriet Wallberg-Henriksson declared that this should become an annual event. Dr Johan Christenson, partner HealthCap, was one of the many invited speakers.
The evening’s hosts David Friberg and Anna Eklöf, students at Karolinska Institutet.
Medicinska Föreningen’s Lucia Ball On the evening of 13 December, Medicinska Föreningen (one of Karolinska Institutet’s two student unions) held its annual Lucia Ball, which also marked the conclusion of the 200th jubilee. The 2010 ball was even more of a festive occasion than usual, and the students paid tribute to Karolinska Institutet in speech and song. Tribute was also
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paid to the 2010 Nobel Prize Laureate in Physiology or Medicine, Robert G. Edwards, who unfortunately was unable to attend in person. Traditionally, the Nobel Laureate always take part in the Lucia Ball. The highlight of the ball was the Lucia procession, featuring Medicinska Föreningen’s Lucia and her sparkling retinue of attendants and star boys.
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The average life expectancy has almost doubled during the last one hundred years! The scientific achievements associated with this increase in longevity and the increase in the percentage of people living to such an age should be acknowledged. In the coming century, science will reach beyond the omics, unravelling complex causes of disease and discovering novel cures. Medicine will become predictive, personalised, preventive and participatory. Patients will need not just genetic data, but also insight into how the environment is turning genes on and off to cause disease. Doctors will focus on maintaining wellness and curing disease. Engineering, biotechnology and public health will move into medicine, and regenerative medicine will be used for many of today’s incurable conditions. All this will offer unique opportunities for developing new approaches to diagnose, prevent, treat and eradicate life-threatening diseases. By acquiring all this knowledge “medicine will shift from care to cure�! Jan Andersson Vice President of Karolinska Institutet
Towards the future This relay baton was handed over to Karolinska Institutet’s students at the Lucia Ball, to be carried forward until the next major jubilee in 50 years’ time. The baton holds the key to a glass box containing films from the bicentenary, as a source of inspiration and a historical document for the future.
Photography: Anna Beijmo, Ulf Bergman, Andreas Beronius, Bildmakarna, Erik Cronberg, Melker Dahlstrand, Maria Deckeman, Cassidy Duhon, Jonas Ekströmer, Kjell Erlandsson, Jesper Fermgård, Getty Images, Martin Ingvar, Karolinska Institutet, Peter Kjellerås, Daniel Klevebring, Lennart Nilsson, Johan Noren, Elina Olivo, Posten, Ulf Sirborn, Lasse Skog, Helena Stigson, Erik G Svensson, Mats Widbom, Stefan Zimmerman Painting: Carl Fredrik von Breda Illustration: Wingårds Design: Karolinska Institutet and Super Editing: Karolinska Institutet Printing: LTAB 2011 ISBN: 978-91-85681-33-4
Karolinska Institutet is one of the world’s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel Laureates in Physiology or Medicine.
Karolinska Institutet
Phone: +46-8-524 800 00
SE-171 77 Stockholm
ki.se
Sweden