Pharmaceutical & Cosmetic Review April 2020

Page 35

SAFETY & HYGIENE

Plant hygiene – a vital part of the production process AECI Specialty Chemicals can assist customers with expert recommendations when it comes to maintaining hygiene standards in a production facility. Microbiologist Davina Pillay highlights why hygiene audits are necessary in cosmetics manufacturing.

H

ygiene within a production

Sources of contamination

facility is a critical factor

Raw materials can be tested before use to determine the initial level of

in controlling and

microbial contamination.

limiting microbial

A decision can then

contamination

be made to use the

of the finished product. Microbial

raw materials as is,

contamination can

or whether further

cause a finished

treatment is needed

product to be

to remove microbial

swabs of the surfaces of various

compromised in

contamination. This

equipment, of raw materials and

terms of texture,

is also dependent on

intermediaries used in production,

appearance

the production

and smell.

process as some

Certain microbes

processes may inadvertently

are hazardous

kill off any microbes present.

to human health.

The equipment used in

For example, E. coli can cause nausea

manufacturing is also considered

and vomiting, Staphylococcus aureus and some yeasts can cause skin infections and certain moulds and the

a source of microbial

DID YOU KNOW?

contamination. Cleaning protocols

before and after cleaning protocols and of the production personnel. The swabs are usually tested for the total bacterial count, which gives an indication of the levels of microbial contamination. The swabs can also be tested for specific microbes. Contact agar plates and dip slides with selective agar media can also be

for manufacturing Consistent cleaning and disinfection with spores they produce can equipment and the biocides are among the cause skin allergies. fundamental preconditions actual equipment for modern and GMPIdeally, products used to clean should compliant hygiene should be manufactured be monitored to standards in cosmetics manufacturing. in a production facility that ensure that microbial

used to take samples. The selective

adheres to and complies

of the hygiene conditions within a

with strict hygiene practices. While this may not always be

contamination does not spread to different sections of the production process.

possible, there are methods that can be used to monitor hygiene levels within a production facility. These include: • monitoring of the

agar media will grow specific types of micro-organisms.

Value-added service A hygiene audit provides a snapshot plant at the time of the audit. It also assists with monitoring and controlling microbial contamination across the

Reduce risk through audits Hygiene audits are a way of monitoring

production plant and with ensuring good product quality. Hygiene auditing is a value-added service offered by AECI Specialty

hygiene practices

Chemicals to customers when they

raw materials used

on site. The aim of

purchase biocides. As part of the

to formulate and

a hygiene audit

service, advice is given by an expert

produce products

is to identify any

microbiologist in terms of sanitisation

potential problem

measures and how to control

• monitoring the manufacturing and cleaning equipment • monitoring packaging equipment and the actual packaging containing the finished products.

areas as well as the processes that

contamination in the customer’s manufacturing plant. •

are effective. A hygiene audit is performed by taking swabs of various points throughout a production facility. These include

AECI Specialty Chemicals – jacques.strydom@aeciworld.com

P C Review | APRIL 2020 |

35


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