What is Post-Prandial Endotoxemia?
Why are its effects on the immune system becoming a leading cause of sudden death? By Wendy Finkelstein Physician Assistant at Hippocrates Health Institute PA-C, MMS, FAAMFM Post-prandial Endotoxemia AKA “Metabolic Endotoxemia” (ME) is becoming increasingly more common. ME is essentially an exacerbation of the leaky gut process which activates the immune system and inflammatory cascades in the body. In severe cases, ME can overwhelm the cardiovascular system and lead to death.
What is Metabolic Endotoxemia?
to five hours after eating an unhealthy
Symptoms of Metabolic
can start as an acute, low grade, persistent,
unrecognized, affect approximately 50%
•
Food sensitivities
•
Nutrient deficiencies (B12, ferritin/
Metabolic Endotoxemia, like leaky gut,
inflammatory driver of many underlying
diseases. When the mucosal barrier of the gut lining becomes permeable, increased toxins from food enter the bloodstream. As a result, this can exacerbate food
allergies and sensitivities, cause bloating, gas, diarrhea, and general malaise.
Our microbiome is colonized with millions of widely varying bacteria. When our diets lack diversity and are high in processed food and saturated fat, overgrowth of unwanted strains of bacteria thrive.
These bacteria increase an inflammatory mediator known as Lipopolysaccharide
(LPS). While normal LPS levels keep our immune system primed and in check,
16
LPS can increase to dangerous levels up
meal. LPS symptoms, although many go
of the Western population and it is caused simply by eating high fat and caloriecrammed processed foods.
LPS-induced Endotoxemia is linked to
Endotoxemia include: •
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Leptin resistance and weight gain
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Mood disorders such as depression
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• • • • • •
Chronic constipation and anxiety
Cognitive decline and memory issues Anorexia and other eating disorders Chronic pain
Parkinson’s and Alzheimer’s disease Low testosterone
Autoimmune disease
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• • • • •
Histamine intolerance
iron, minerals, and fat soluble vitamins)
Autoimmune disease Fatigue
Anxiety and depression Weight gain
Hyperlipidemia and high triglycerides Insulin resistance and diabetes Inflammation and pain
