MANUFACTURING
PHYTOCHEMICALBASED NANO FORMULATIONS A potential approach to address
bottleneck issue of drug resistant cancer
More than 90 per cent cancer deaths are ascribed to Multi Drug Resistance (MDR). MDR is the condition, which is either intrinsic or acquired, characterised by resistance towards conventional as well as novel chemotherapeutics. Multifunctional, multi-targeting nanophytochemicals is now being considered as potential hope in the form of synergistic therapeutics. Abhijeet Dattatraya Kulkarni, SRES’s Sanjivani College of Pharmaceutical Education and Research
62
P H A RM A F O C U S A S I A
ISSUE 43 - 2021
C
ancer is characterised by unrestrained growth of abnormal cells which have potential to alter genome, dynamically. Invasion of nearby tissues and ability to metastasise by such cells hamper the normal biofunction of healthy cells. According to recently published statistical reports, almost 90 per cent of advance stage cancer patient’s death can be ascribed to cancer drug resistance. Cancer drug resistance is complex phenomenon and can be categorised as intrinsic or acquired resistance. In few cases, cancer cells survive even at the
