MANUFACTURING
Human Vaccine Candidates Discovery and Development on Non-Animal Systems An adoption with meaningful repercussions The principles of Humane Experimental Technique has resulted in 3Rs concept: Replacement, Reduction and Refinement of animal tests. The number of animals used for both preclinical and quality control is thought to be reduced to zero if vaccines are better characterised while allowing testings by a set of in vitro methods rather than in vivo scenarios. The in vitro methods to detect safety related to potency of vaccines can employ alternative platforms like that of human derived cell/tissue based surrogate systems - The humane technique facilitating increased control of critical steps in production, relating safety with potency, international harmonisation and validation of test procedures S Dravida, CEO, Transcell Oncologics
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vaccine is traditionally a biological substance containing a harmless form of the causative organism that causes a particular disease. It is usually given to healthy population by injection, to prevent the contraction of the disease. New age companies like Moderna have defied this definition of a vaccine to work on mRNA platforms where information from viral genomes is used to produce viral proteins from within a cell developing vaccine candidates.
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P H A RM A F O C U S A S I A
ISSUE 40 - 2020
Vaccines are biological and formulations that boost the human body’s ability to fight against the targeted infectious diseases. The biological preparations fuel the recipient’s immune system stimulating to recognise targeted aspects of infectious organisms (bacteria and virus) as foreign; generate host reaction or response to regulate or completely eliminate them. In addition to this, Vaccines evoke immunological memory of the targeted aspect, which provides protection against any
