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MEDICAL
From bomb-detection to virus-detection In a fascinating tale of transformation and ingenuity, Melbourne-based GreyScan worked with the University of Tasmania in a race to develop the world’s first mobile virus detection device, re-engingeered from a device that was originally an explosives-detector. The SARS-CoV-2 coronavirus strain at the heart of the the COVID-19 pandemic cannot be seen, is difficult to detect, and is continuing to mutate as scientists race to find a vaccine. According to recent studies, the virus is detectable in aerosols for up to three hours, up to four hours on copper, up to 24 hours on cardboard, and two-three days on plastic and stainless steel. Currently there are no means to check how effective cleaning protocols are, or to determine the virus’s presence in public places. There is therefore a significant need for environmental testing for COVID-19 to determine whether hospitals, schools, surfaces and personal protective equipment are clear of the virus. In order to jumpstart the economy, proactive – rather than reactive – methods to quickly identify the virus must be developed. A company developing such a proactive tool is Port-Melbourne-based GreyScan, in collaboration with the University of Tasmania. This exciting research project could pave the way for the development of a world-first: a mobile virus detection device that will be able to detect the coronavirus on surfaces. The science of “trace detection” expands on the trace explosives detection technology invented 15 years ago by Professor Michael Breadmore’s team at the University of Tasmania, and commercialised, manufactured and deployed by GreyScan. Breadmore recalls the challenge: “We were asked to rapidly detect explosives and reduce a 30-minute process to 30 seconds.” The resultant device, the GreyScan ETD-100, was the world’s first compact, inorganic explosives trace detector, which is capable of detecting trace levels of explosives in a few minutes. The technology is the first in the world to detect homemade inorganic explosives, overcoming the limitation of existing screening techniques that struggle to detect modern explosives. Employed globally, it outperforms by up to ten times the current standards sought by the US Government. The modular nature of the explosives-detector allows it to be reengineered to detect a wide variety of substances, including viruses. “It is not possible to implement existing diagnostic approaches in a time that is suitable for rapid screening,” says Breadmore. “Our approach is truly unique in the world and in the diagnostic space.” GreyScan CEO Samantha Ollerton says the research represented the first step towards developing the GreyScan TVD-1 (Trace Virus Detector), which could be used to detect the virus in airports, public transportation systems and places of mass gatherings, as well as being deployed in the testing of people. The device would help the public to feel safe again and enable people to return to their normal routines by demonstrating that cleaning or decontamination protocols have been followed. “The use of contact tracing and people testing will be augmented by the capability of the TVD-1, providing fast, accurate detection that can be used by anyone anywhere” adds Ollerton. The technology is based on capillary zone electrophoresis (CZE) – a technique previously used for the analysis and characterisation of human viruses such as common cold virus and adenovirus. The initial research is supported by $260,000 in co-funding from the CSIRO Innovation Connections Grant scheme and industry partner GreyScan. “This is a product for the future fight against this and any other viruses that we encounter in our lifetimes.” Adds Ollerton. The research is taking place in the University of Tasmania’s lab facilities, where Breadmore will be joined by a team of researchers
AMT AUG/SEP 2020
Professor Michael Breadmore and Mostafa Adel Atia Abuzeid with the GreyScan unit at the University of Tasmania.
"Our research will develop a way to collect, analyse and detect viruses from surfaces within a few minutes." Professor Michael Breadmore who will develop biosensors to help detect the virus. Professor Anna King explains that biosensors played an important role by binding to and detecting viruses such as SARS-CoV-2. “We will be developing multiple types of biosensors that can bind to the virus in different ways, as well as the systems that best allow us to detect even the smallest amounts of the virus,” she adds. GreyScan believes this device will be the first in a line of products that will be able to detect surface viruses as they evolve and spread throughout the globe. It is suggested that an engineering prototype will be ready within six months, then a more advanced prototype for testing in the field is expected to be ready in 12 months. The GreyScan ETD-100TM explosives-detection device was a world-first then, and its transformation to virus-detection is a worldfirst now, as it tackles one of the world’s biggest health challenges. www.greyscandetection.com www.utas.edu.au
