The Protein Pallidin and its Prognosis in Schizophrenia Ece Su Sayin
The mental disorder schizophrenia has been a key research area for the past few decades considering the high number of people that suffer from it. The etiology of schizophrenia is still not known, but there are many theories on it. One of the theories made by Shi et al. (2017) show that Pallidin promotes transcriptional activity of p38. The overexpression of p38 leads to cell differentiation. The problem is that when Pallidin is present, this inhibits growth proteins such as Coronin 1b and Rab13. When this overexpression without the important growth factors takes place, this leads to abnormal neuronal development. The authors hypothesize that Pallidin influence growth of nerve processes via p38 and this causes abnormally developed brains, increasing risk of schizophrenia. What the authors could not fully conclude is when this overexpression happens, does it lead to schizophrenia like they assume. Key Words: Schizophrenia; Neurodevelopment; Pallidin; P38
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