Immune alteration using human mesenchymal stem cells in schizophrenia: a review Xiaoke Jiang
Schizophrenia is a serious mental disorder characterized by positive, negative and cognitive symptoms, the word “Schizophrenia” is proposed almost a century ago, yet we do not know the pathology behind it. There are many lines of evidence pointing out the correlation between microglial activation and neuroinflammation in schizophrenia proposing the control of microglial activation potentially could be a therapeutic direction in schizophrenia treatment. In this review, we assess the potential use of human mesenchymal stem cells with its immunosuppression and immunomodulatory property to decrease schizophrenia-relevant behavioral abnormality targeting microglial activation. This review answers two questions, “Can cytokine level be a diagnostics marker in schizophrenia” and “Can human mesenchymal stem cells be a therapeutic drug for schizophrenia” Using the answers to these two questions, critical analysis and future prospect of clinical interpretation is proposed.
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